ABSTRACT:

Vitamin C is an essential micronutrient responsible for antioxidant defense, collagen synthesis, and immune regulation. It enters cells through Sodium-Dependent Vitamin C Transporter 1 (SVCT1) and Sodium-Dependent Vitamin C Transporter 2 (SVCT2), which are produced from Solute Carrier Family 23 Member 1 (SLC23A1) and Solute Carrier Family 23 Member 2 (SLC23A2) genes. Among these, SLC23A1 plays a key role in the absorption and reabsorption of vitamin C in epithelial tissues. Genetic variations can affect vitamin C status, potentially contributing to chronic disease risk. SLC23A1 is closely linked to vitamin C homeostasis, as changes in its expression can affect the efficiency of vitamin C absorption and utilization. This review examines the molecular mechanisms of SLC23A1-mediated vitamin C transport, its role in nutrient metabolism, and the implications of genetic variation for human health, while providing critical insights into food and nutritional science based on SLC23A1 gene expression. SLC23A1 and vitamin C work together in health processes, antioxidant defenses, and metabolism to support the body’s function. Understanding the regulation of SLC23A1 may improve nutritional approaches to modulate antioxidant levels and prevent chronic disease.

Keywords: Vitamin C, SLC23A1, Diet, Nutrigenomic, Antioxidant

How to Cite this paper?