ABSTRACT:

This study explores the bioactive properties of Colocasia esculenta leaf extracts, focusing on their antioxidant, antimicrobial, thrombolytic, and cytotoxic activities. Several solvent extracts, including aqueous methanol, ethyl acetate, n-hexane, n-butanol, and chloroform, were analyzed for their efficacy. Among these, the aqueous methanol extract demonstrated the highest levels of phenolic and flavonoid compounds, corresponding to superior antioxidant and antimicrobial activities. Notable, significant thrombolytic activity was observed, with clot lysis percentages ranging from 27.69% to 48.78%. Hemolytic activity assays revealed varying levels of cytotoxicity among the extracts, with the aqueous methanol extract causing the least red blood cell lysis. Pearson correlation analysis revealed a positive relationship between total phenolic content, flavonoid content and inhibition potential, antimicrobial properties, and thrombolytic activities. Conversely, IC₅₀ values and hemolytic activity showed negative correlations with these bioactive compounds. The findings confirm the presence of potent phenolic antioxidants in Colocasia esculenta leaves, supporting their potential applications in nutraceutical formulations and functional foods. Further research is recommended to elucidate the primary mechanisms of these bioactivities and validate their therapeutic potential in clinical applications.

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