Drugs overdose poses a serious threat on human health and may be occur with (ciprofloxacin, chloroquin, piperazine, phyllocontin, digoxin and diazepam).The objective of this study was to examine the adsorption of these drugs onto the Iraqi kaolin clay surface, which used for the temporary treatment of these drugs overdose when this occur. In this work a UV-Visible spectrophotometer has been used to determine the adsorption isotherms which were of type (S₃,S₄) according to Giles classification and these isotherms were analyzed by the Freundlich and Langmuir equations using linearized correlation coefficient, the characteristic parameters for each isotherm have been determined. The effect of temperature, acid function, and initial drug concentration were chosen as experimental parameters. The results showed that the adsorption process attained equilibrium within seventy minutes. Thermodynamic parameters such as ΔH, ΔG, and ΔS were calculated. The adsorption process was found to be exothermic and non-spontaneous for (ciprofloxacin, chloroquin, piperazine, phyllocontin and diazepam while for digoxin was endothermic and non-spontaneous.