ABSTRACT:
The growing bacterial resistance to currently used antibiotics emphasizes the need to explore novel substances with efficacy against harmful microorganisms. Despite the availability of diverse classes of disinfectant agents, the development of drug resistance among pathogenic bacteria remains a current issue. The wide array of chemical structures and mechanisms of action further complicates the goal for a definitive approach to discovering new pharmaceuticals. The requirement to manufacture newly discovered drugs is condemnatory, as contagious microorganisms can spread swiftly throughout the body and cause ailments such as epidemic cholera, Salmonella typhi infection, pleurisy, and plague. The search for novel, targeted, and safe antibacterial agents has emerged as a pivotal area of research in organic chemistry. In this research study, nicotinamide and different benzaldehydes were condensed to produce a series of Schiff bases. Nicotinamidium products are of significant importance and find utility across various fields due to their distinct properties. The synthesized compound was thoroughly distinguished by UV-vis, FTIR, and NMR (¹H-NMR & ¹³CNMR spectroscopy). Antimicrobial activities were tested against bacteria (E. coli and S. aureus) using the disc diffusion method, with ciprofloxacin as the standard. According to the data, the product demonstrated significant antibacterial activity against the tested bacterial strains. To evaluate the antioxidant potential, the DPPH radical scavenging assay was employed. The antioxidant applications demonstrated moderate inhibition of oxidation.
Keywords: Schiff base, Nicotinamide Synthesis, Antimicrobial, Antioxidant, Spectroscopy,

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