|
Research Article | Open Access
Volume 5 | Issue 1 | https://doi.org/10.15228/2015.v05.i01.p04
|
Synthetic N-Alkyl/aralkyl-4-methyl-N-(naphthalen-1-yl) benzenesulfonamides as Potent Antibacterial Agents
A. Abbasi
Department of Chemistry, Government College University, Lahore, Pakistan
S. Manzoor
Department of Chemistry, Government College University, Lahore, Pakistan
Aziz-ur-Rehman
Department of Chemistry, Government College University, Lahore, Pakistan
S. Z. Siddiqui
Department of Chemistry, Government College University, Lahore, Pakistan
I. Ahmad
Department of Pharmacy, The Islamia University of Bahawalpur, Pakistan.
R. Malik
Department of Pharmacy, The Islamia University of Bahawalpur, Pakistan.
M. Ashraf
Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
Qurat-ul-Ain
Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
S. A. A. Shah
Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia.
Atta-ur-Rahman Institute for Natural Products Discovery (AuRIns), Level 9, FF3, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia.
| Received 06 Mar, 2015 |
Accepted 21 Sep, 2015 |
Published 06 Dec, 2015 |
ABSTRACT:
The current research effort involved the reaction of napthalen-1-amine (1) with 4-methylbenzenesulfonyl chloride (2) under dynamic pH control at 9-10, maintained with 10% aqueous Na2CO3 to obtain 4-methyl-N-(naphthalen-1-yl) benzenesulfonamide (3). The parent molecule 3 was further substituted at N-atom with alkyl/aralkyl halides (4a-f) in polar aprotic solvent; N,N-dimethylformamide, and lithium hydride which acts as a base, to achieve N-alkyl/aralkyl-4-methyl-N-(naphthalen-1-yl)benzenesulfonamides (5a-f). All the synthesized compounds were structurally elucidated by IR, 1H-NMR and EIMS spectral techniques. All the derivatives were further screened for antibacterial and anti-enzymatic potential against various bacterial strains and enzymes, respectively, and were found to be potent antibacterial agents and moderate to weak enzyme inhibitors.
How to Cite this paper?
APA-7 Style
Abbasi, M. A., Manzoor, S., Aziz-ur-Rehman, S. S., Ahmad, I., Malik, R., Ashraf, M., & Qurat-ul-Ain, S. S. (2015). Synthetic N-Alkyl/aralkyl-4-methyl-N-(naphthalen-1-yl) benzenesulfonamides as Potent Antibacterial Agents. Pak J Chem, 5, 23-29. https://doi.org/10.15228/2015.v05.i01.p04
ACS Style
Abbasi, M.A., Manzoor, S., Aziz-ur-Rehman, S.S., Ahmad, I., Malik, R., Ashraf, M. and Qurat-ul-Ain, S.S., 2015. Synthetic N-Alkyl/aralkyl-4-methyl-N-(naphthalen-1-yl) benzenesulfonamides as Potent Antibacterial Agents. Pak J Chem, 5, pp.23-29. https://doi.org/10.15228/2015.v05.i01.p04
AMA Style
Abbasi MA, Manzoor S, Aziz-ur-Rehman SS, Ahmad I, Malik R, Ashraf M, Qurat-ul-Ain SS. Synthetic N-Alkyl/aralkyl-4-methyl-N-(naphthalen-1-yl) benzenesulfonamides as Potent Antibacterial Agents. Pak J Chem. 2015 Mar 1;5:23-9. https://doi.org/10.15228/2015.v05.i01.p04
Chicago/Turabian Style
Abbasi, M. A., S. Manzoor, Siddiqui SZ Aziz-ur-Rehman, I. Ahmad, R. Malik, M. Ashraf, and Shah SAA Qurat-ul-Ain. “Synthetic N-Alkyl/aralkyl-4-methyl-N-(naphthalen-1-yl) benzenesulfonamides as Potent Antibacterial Agents.” Pak J Chem 5 (2015): 23-29. https://doi.org/10.15228/2015.v05.i01.p04
This work is licensed under a Creative Commons Attribution 4.0 International License.