Antibacterial and Enzyme Inhibition Studies of N‘-Substituted Benzylidene-2-(2, 4-Dimethylphenoxy) Acetatohydrazides

S. Nadeem

Department of Chemistry, School of Science and Technology, University of Management & Technology, Lahore, Pakistan

Aziz Ur Rehman

Department of Chemistry, Government College University, Lahore-54000, Pakistan

M.A. Abbasi

Department of Chemistry, Government College University, Lahore-54000, Pakistan

S.Z. Siddiqui

Department of Chemistry, Government College University, Lahore-54000, Pakistan

S. Rasool

Department of Chemistry, Government College University, Lahore-54000, Pakistan

I. Ahmad

Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

S. Afzal

Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

Received
02 Mar, 2014

Accepted
21 Sep, 2014

Published
06 Dec, 2014

The molecules bearing azomethine group are known to possess biological activities. In the present work, the synthesis of N’– Substitutedbenzylidene-2-(2, 4-dimethylphenoxy) acetatohydrazide (5a-d) has been elaborated using 2,4-Dimethylphenol (1) as precursor. The molecule, 1, was converted to ethyl 2-(2,4-dimethylphenoxy)acetate (2) on refluxing with ethyl 2-bromoacetate in ethanol in the presence of KOH. Ethyl ester, 2, was refluxed with hydrated hydrazine (80%) in ethanol to yield 2-(2,4- dimethylphenoxy) acetohydrazide (3). The target molecules, 5a-d, were synthesized by stirring 3 with phenyl/aryl carboxaldehyde (4a-d) in methanol in the presence of glacial acetic acid. The synthesized molecules were characterized by spectral data and evaluated for antibacterial and anti-enzymatic activities.

How to Cite this paper?

APA-7 Style
Nadeem, S., Rehman, A.U., Abbasi, M.A., Siddiqui, S.Z., Rasool, S., Ahmad, I., Afzal, S. (2014). Antibacterial and Enzyme Inhibition Studies of N‘-Substituted Benzylidene-2-(2, 4-Dimethylphenoxy) Acetatohydrazides
. Pakistan Journal of Chemistry, 4(3), 96-100. https://doi.org/10.15228/2014.v04.i03.p01

ACS Style
Nadeem, S.; Rehman, A.U.; Abbasi, M.A.; Siddiqui, S.Z.; Rasool, S.; Ahmad, I.; Afzal, S. Antibacterial and Enzyme Inhibition Studies of N‘-Substituted Benzylidene-2-(2, 4-Dimethylphenoxy) Acetatohydrazides
. Pak. J. Chem. 2014, 4, 96-100. https://doi.org/10.15228/2014.v04.i03.p01

AMA Style
Nadeem S, Rehman AU, Abbasi MA, Siddiqui SZ, Rasool S, Ahmad I, Afzal S. Antibacterial and Enzyme Inhibition Studies of N‘-Substituted Benzylidene-2-(2, 4-Dimethylphenoxy) Acetatohydrazides
. Pakistan Journal of Chemistry. 2014; 4(3): 96-100. https://doi.org/10.15228/2014.v04.i03.p01

Chicago/Turabian Style
Nadeem, S., Aziz Ur Rehman, M. A. Abbasi, S. Z. Siddiqui, S. Rasool, I. Ahmad, and S. Afzal. 2014. “Antibacterial and Enzyme Inhibition Studies of N‘-Substituted Benzylidene-2-(2, 4-Dimethylphenoxy) Acetatohydrazides
” Pakistan Journal of Chemistry 4, no. 3: 96-100. https://doi.org/10.15228/2014.v04.i03.p01

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