Research Article | Open Access
Volume 5 | Issue 3 | https://doi.org/10.15228/2015.v05.i03.p07
|
Synthesis, Characterization, and In-Vitro Anti-Microbial and Anti-Oxidant Activities of Co+2, Ni+2, Cu+2 and Zn+2 Complexes of 5-chloro-2-hydroxybenzaldehyde-N-(2-oxo1,2-dihydro-3H-indol-3-ylidene) hydrazone
Z. Khan
Department of Chemistry, Faculty of Science, University of Karachi, Karachi-75270, Pakistan
Z. T. Maqsood
Department of Chemistry, Faculty of Science, University of Karachi, Karachi-75270, Pakistan
M. A. K. Tanoli
Department of Chemistry, Faculty of Science, University of Karachi, Karachi-75270, Pakistan
L. Iqbal
Department of Chemistry, Faculty of Science, University of Karachi, Karachi-75270, Pakistan
M. Lateef
Pakistan Council of Scientific and Industrial Research Laboratories Complex, Karachi-75270, Pakistan
Received 27 Jan, 2015 |
Accepted 10 Feb, 2015 |
Published 31 Dec, 2015 |
New transition metal complexes of a Schiff base (5-chloro-2-hydroxybenzaldehyde-N-(2-oxo-1,2-dihydro-3H-indol-3-
ylidene)hydrazone) have been synthesized, characterized and evaluated in-vitro for their anti-microbial and anti-oxidant activities.
Modern characterization techniques including CHN, IR, UV-Vis, AAS and SEM have been employed for characterization. The
bis Schiff base found to be a tridentate ligand and coordinated to the metal centers through its phenolic oxygen, azomethine
nitrogen and carbonyl group. On the basis of spectral evidences and magnetic susceptibility data of complexes, square planner
geometry is proposed for Cu+2 complex, distorted tetrahedral geometry is proposed for Zn+2 while octahedral geometries are
proposed for Co+2 and Ni+2 complexes. Results of antimicrobial studies revealed that the metal complexes are more potent
bactericide and fungicide agents. This boost in activity can be explained on the basis of chelation theory suggesting that chelation
reduces the polarity of metal ions which increase the lipophilic nature of the complex and hence is able to cross the lipid barrier
layer of cell membrane to interfere normal cell functions leading to cell death. On the other hand however, Schiff base ligand
showed more DPPH radical scavenging activity compared to the complexes which is attributed to the presence of OH group in the
Schiff base.
How to Cite this paper?
APA-7 Style
Z. Khan, Z. T. Maqsood, M. A. K. Tanoli, L. Iqbal, M. Lateef. (2015). Synthesis, Characterization, and In-Vitro Anti-Microbial and Anti-Oxidant Activities of Co+2, Ni+2, Cu+2 and Zn+2 Complexes of 5-chloro-2-hydroxybenzaldehyde-N-(2-oxo1,2-dihydro-3H-indol-3-ylidene)hydrazone . Pakistan Journal of Chemistry, 5(3), 138-145. https://doi.org/10.15228/2015.v05.i03.p07
ACS Style
Z. Khan, Z. T. Maqsood, M. A. K. Tanoli, L. Iqbal, M. Lateef. (2015). Synthesis, Characterization, and In-Vitro Anti-Microbial and Anti-Oxidant Activities of Co+2, Ni+2, Cu+2 and Zn+2 Complexes of 5-chloro-2-hydroxybenzaldehyde-N-(2-oxo1,2-dihydro-3H-indol-3-ylidene)hydrazone . Pak. J. Chem. 2015, 5, 138-145. https://doi.org/10.15228/2015.v05.i03.p07
AMA Style
Z. Khan, Z. T. Maqsood, M. A. K. Tanoli, L. Iqbal, M. Lateef. (2015). Synthesis, Characterization, and In-Vitro Anti-Microbial and Anti-Oxidant Activities of Co+2, Ni+2, Cu+2 and Zn+2 Complexes of 5-chloro-2-hydroxybenzaldehyde-N-(2-oxo1,2-dihydro-3H-indol-3-ylidene)hydrazone . Pakistan Journal of Chemistry. 2015; 5(3): 138-145. https://doi.org/10.15228/2015.v05.i03.p07
Chicago/Turabian Style
Z. Khan, Z. T. Maqsood, M. A. K. Tanoli, L. Iqbal, M. Lateef. (2015). Synthesis, Characterization, and In-Vitro Anti-Microbial and Anti-Oxidant Activities of Co+2, Ni+2, Cu+2 and Zn+2 Complexes of 5-chloro-2-hydroxybenzaldehyde-N-(2-oxo1,2-dihydro-3H-indol-3-ylidene)hydrazone . Pakistan Journal of Chemistry 5, no. 3: 138-145. https://doi.org/10.15228/2015.v05.i03.p07
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