Research Article | Open Access Volume 5 | Issue 2 | https://doi.org/10.15228/2015.v05.i02.p05 |
Synthesis, Spectral Analysis and Antibacterial Activity of Some new N-Substituted Sulfonamide Derivatives of 1,3-Benzodioxol-5-amine
Aziz Ur Rehman
Department of Chemistry, Government College University, Lahore-54000, Pakistan
A. Siddiqa
Department of Chemistry, Government College University, Lahore-54000, Pakistan
M.A. Abbasi
Department of Chemistry, Government College University, Lahore-54000, Pakistan
S.Z. Siddiqui
Department of Chemistry, Government College University, Lahore-54000, Pakistan
H. Khalid
Department of Chemistry, Government College Women University, Sialkot-51310, Pakistan
S. Rasool
Department of Chemistry, Government College University, Lahore-54000, Pakistan
I. Ahmed
Department of Pharmacy; TheIslamia University of Bahawalpur, Bahawalpur-63100, Pakistan
R. Malik
Department of Pharmacy; TheIslamia University of Bahawalpur, Bahawalpur-63100, Pakistan
| Received 10 Mar, 2015 | Accepted 25 Sep, 2015 | Published 10 Dec, 2015 |
1,3-Benzodioxol-5-amine(1)was used as a precursor to synthesize N-alkyl/aralkyl-N-(1,3-benzodioxol-5-yl) arylsulfonamide derivatives, 7a-b to 9a-b. The molecule 1 was reacted with arylsulfonyl chlorides, 2a-b,on stirring in a dilute aqueous sodium carbonate solution to synthesize N-(1,3-benzodioxol-5-yl) arylsulfonamide, 3a-b. The molecules, 3a-b, were further stirred with alkyl/aralkyl halides, 4-6, in DMF at RT to get the desired final compounds, 7a-bto 9a-b.The synthesized molecules were structurally confirmed by IR, 1H-NMR and EIMS spectral data. The antibacterial activity of these compounds rendered them moderately weak inhibitors relative to ciprofloxacin, the reference standard.
How to Cite this paper?
APA-7 Style
Rehman, A.U., Siddiqa, A., Abbasi, .A., Siddiqui, S.Z., Khalid, H., Rasool, S., Ahmed, I., Malik, R. (2015). Synthesis, Spectral Analysis and Antibacterial Activity of Some new N-Substituted Sulfonamide Derivatives of 1,3-Benzodioxol-5-amine. Pakistan Journal of Chemistry, 5(2), 77-81. https://doi.org/10.15228/2015.v05.i02.p05
ACS Style
Rehman, A.U.; Siddiqa, A.; Abbasi, .A.; Siddiqui, S.Z.; Khalid, H.; Rasool, S.; Ahmed, I.; Malik, R. Synthesis, Spectral Analysis and Antibacterial Activity of Some new N-Substituted Sulfonamide Derivatives of 1,3-Benzodioxol-5-amine. Pak. J. Chem. 2015, 5, 77-81. https://doi.org/10.15228/2015.v05.i02.p05
AMA Style
Rehman AU, Siddiqa A, Abbasi A, Siddiqui SZ, Khalid H, Rasool S, Ahmed I, Malik R. Synthesis, Spectral Analysis and Antibacterial Activity of Some new N-Substituted Sulfonamide Derivatives of 1,3-Benzodioxol-5-amine. Pakistan Journal of Chemistry. 2015; 5(2): 77-81. https://doi.org/10.15228/2015.v05.i02.p05
Chicago/Turabian Style
Rehman, Aziz, Ur, A. Siddiqa, M. A. Abbasi, S. Z. Siddiqui, H. Khalid, S. Rasool, I. Ahmed, and R. Malik. 2015. “Synthesis, Spectral Analysis and Antibacterial Activity of Some new N-Substituted Sulfonamide Derivatives of 1,3-Benzodioxol-5-amine” Pakistan Journal of Chemistry 5, no. 2: 77-81. https://doi.org/10.15228/2015.v05.i02.p05
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