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Research Article | Open Access
Volume 5 | Issue 2 | https://doi.org/10.15228/2015.v05.i02.p01
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Synthesis and Antibacterial Activity Study of N-Substituted Acetamide Derivatives of 4-Hydroxy-2-oxo-2H-Chromene
A. U. Rehman
Department of Chemistry, Government College University, Lahore, Pakistan
S. Rasool
Department of Chemistry, Government College University, Lahore, Pakistan
M.A. Abbasi
Department of Chemistry, Government College University, Lahore, Pakistan
S.Z. Siddiqui
Department of Chemistry, Government College University, Lahore, Pakistan
A. Riaz
Department of Chemistry, Government College University, Lahore, Pakistan
A. Tahir
Department of Chemistry, Government College University, Lahore, Pakistan
H.M.A. Asif
Department of Chemistry, Government College University, Lahore, Pakistan
I. Ahmad
Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
| Received 12 Mar, 2015 |
Accepted 27 Sep, 2015 |
Published 12 Dec, 2015 |
The heterocyclic coumarin derivatives are well known for their biological potential. The presented work demonstrates the evaluation of some N-substituted acetamoyl derivatives of 4-hydroxy-2-oxo-2H-chromene (4)against certain strains of gram bacteria. First, N-substituted-2-bromoacetamide, 3a-r, were synthesized by the reaction of aralkyl/aryl amines, 1a-r, with 2- bromoacetyl bromide (2) in an aqueous medium under definite pH control. In the second step, the resulted electrophiles, 3a-r, were made to react 4in a polar aprotic solvent using a weak base as an activator to synthesize the final N-substituted-2-[(2-oxo-2H-chromen-4-yl)oxy]acetamide, 5a-r. The synthesis of compounds, 5a-r, was corroborated by TLC initially and spectral data of IR,1H-NMR and EIMS finally. The MIC results of antibacterial activity rendered these molecules valuable inhibitors of all the bacterial strains taken into account.
How to Cite this paper?
APA-7 Style
Rehman, A.U., Rasool, S., Abbasi, M.A., Siddiqui, S.Z., Riaz, A., Tahir, A., Asif, H.M., Ahmad, . (2015). Synthesis and Antibacterial Activity Study of N-Substituted Acetamide Derivatives of 4-Hydroxy-2-oxo-2H-Chromene. Pakistan Journal of Chemistry, 5(2), 50-57. https://doi.org/10.15228/2015.v05.i02.p01
ACS Style
Rehman, A.U.; Rasool, S.; Abbasi, M.A.; Siddiqui, S.Z.; Riaz, A.; Tahir, A.; Asif, H.M.; Ahmad, . Synthesis and Antibacterial Activity Study of N-Substituted Acetamide Derivatives of 4-Hydroxy-2-oxo-2H-Chromene. Pak. J. Chem. 2015, 5, 50-57. https://doi.org/10.15228/2015.v05.i02.p01
AMA Style
Rehman AU, Rasool S, Abbasi MA, Siddiqui SZ, Riaz A, Tahir A, Asif HM, Ahmad . Synthesis and Antibacterial Activity Study of N-Substituted Acetamide Derivatives of 4-Hydroxy-2-oxo-2H-Chromene. Pakistan Journal of Chemistry. 2015; 5(2): 50-57. https://doi.org/10.15228/2015.v05.i02.p01
Chicago/Turabian Style
Rehman, Aziz, Ur, S. Rasool, M. A. Abbasi, S. Z. Siddiqui, A. Riaz, A. Tahir, H. M.A. Asif, and I. Ahmad. 2015. “Synthesis and Antibacterial Activity Study of N-Substituted Acetamide Derivatives of 4-Hydroxy-2-oxo-2H-Chromene” Pakistan Journal of Chemistry 5, no. 2: 50-57. https://doi.org/10.15228/2015.v05.i02.p01
This work is licensed under a Creative Commons Attribution 4.0 International License.