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Research Article | Open Access
Volume 5 | Issue 1 | https://doi.org/10.15228/2015.v05.i01.p03
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Antibacterial and Enzyme Inhibition Study of Hydrazone Derivatives Bearing 1, 3, 4-Oxadiazole
S. Rasool
Department of Chemistry, Government College University, Lahore-54000, Pakistan.
A.U. Rehman
Department of Chemistry, Government College University, Lahore-54000, Pakistan.
M. A. Abbasi
Department of Chemistry, Government College University, Lahore-54000, Pakistan.
S. Z. Siddiqi
Department of Chemistry, Government College University, Lahore-54000, Pakistan.
A. S. Gondal
Department of Chemistry, Government College University, Lahore-54000, Pakistan.
H. A. Noor
Department of Chemistry, Government College University, Lahore-54000, Pakistan.
S. Sheral
Department of Chemistry, Government College University, Lahore-54000, Pakistan.
I. Ahmad
Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan.
| Received 06 Mar, 2015 |
Accepted 21 Sep, 2015 |
Published 06 Dec, 2015 |
ABSTRACT:
The antibacterial and lipoxygenase enzyme inhibition activities of two series of compounds have been investigated in the presented work. The 4-methyl/hydroxy benzoic acids (1a & 1b) were used as starting materials to prepare corresponding esters (2a & 2b), hydrazides (3a & 3b), 5-(4-methylphenyl/4-hydroxyphenyl)-1,3,4-oxadiazol-2-thiols (4a & 4b), S-substituted esters (5a & 5b) and acetohydrazides (6a & 6b). The acetohydrazones, 8a-i & 9a-i, were synthesized by stirring 6a & 6b with mono(di)substituted phenylcarboxaldehydes (7a-i) in methanol. The data of IR, 1H-NMR and EIMS spectral techniques well confirmed the structural formulae of synthesized compounds. The molecules of 4-methyl series rendered the better results than those of 4-hydroxy series.
How to Cite this paper?
APA-7 Style
Rasool, S., Abbasi, M. A., Siddiqi, S. Z., Gondal, A. S., Noor, H. A., Sheral, S., & Ahmad, I. (2015). Antibacterial and Enzyme Inhibition Study of Hydrazone Derivatives Bearing 1, 3, 4-Oxadiazole. Pakistan Journal of Chemistry, 5(1). https://doi.org/10.15228/2015.v05.i01.p03
ACS Style
Rasool, S., Abbasi, M.A., Siddiqi, S.Z., Gondal, A.S., Noor, H.A., Sheral, S. and Ahmad, I., 2015. Antibacterial and Enzyme Inhibition Study of Hydrazone Derivatives Bearing 1, 3, 4-Oxadiazole. Pakistan Journal of Chemistry, 5(1). https://doi.org/10.15228/2015.v05.i01.p03
AMA Style
Rasool S, Abbasi MA, Siddiqi SZ, Gondal AS, Noor HA, Sheral S, Ahmad I. Antibacterial and Enzyme Inhibition Study of Hydrazone Derivatives Bearing 1, 3, 4-Oxadiazole. Pakistan Journal of Chemistry. 2015 Mar 1;5(1). https://doi.org/10.15228/2015.v05.i01.p03
Chicago/Turabian Style
Rasool, S., M. A. Abbasi, S. Z. Siddiqi, A. S. Gondal, H. A. Noor, S. Sheral, and I. Ahmad. “Antibacterial and Enzyme Inhibition Study of Hydrazone Derivatives Bearing 1, 3, 4-Oxadiazole.” Pakistan Journal of Chemistry 5, no. 1 (2015). https://doi.org/10.15228/2015.v05.i01.p03
This work is licensed under a Creative Commons Attribution 4.0 International License.