Synthesis and Biological Screening of N-(Dimethylphenyl Substituted)-N-Ethyl/Benzyl4-Chlorobenzenesulfonamide Derivatives

Aziz Ur Rehman

Department of Chemistry, Government College University, Lahore, Pakistan

I. Ahmad

Department of Chemistry, Government College University, Lahore, Pakistan

M.A. Abbasi

Department of Chemistry, Government College University, Lahore, Pakistan

S. Z. Siddiqui

Department of Chemistry, Government College University, Lahore, Pakistan

K. Nafeesa

Department of Chemistry, Government College University, Lahore, Pakistan

A. Sattar

Department of Chemistry, Government College University, Lahore, Pakistan

I. Ahmed

Department of Pharmac, The Islamia University of Bahawalpur, Pakistan

S. Afzal

Department of Pharmac, The Islamia University of Bahawalpur, Pakistan

In the undertaken research, a number of N-dimethylphenyl substituted derivatives of N-ethyl/benzyl-4-chlorobenzenesulfonamide, (6a-f & 7a-f) was synthesized and also estimated for their biological potential. The reaction of 4-chlorobenzenesulfonyl chloride with different dimethyl substituted phenyl amine (2a-f) in the presence of basic aqueous media yielded N-[(Dimethyl substituted) phenyl]-4-chlorobenzenesulfonamides (3a-f). The targeted compounds 6a-f & 7a-f were synthesized by the reaction of compounds 3a-f with electrophiles, ethyl bromide/benzyl chloride in the presence of base NaH and polar aprotic solvent (DMF). The structures of the compounds were elucidated through ¹H-NMR, IR and mass spectral data. The synthesized compounds (6a-f & 7a-f) were screened against Gram-negative & Gram-positive bacteria and also subjected for enzyme inhibition potential against lipoxygenase and chymotrypsin enzymes and almost all the compounds exhibited moderate to good activities.

How to Cite this paper?

APA-7 Style
Rehman, A.U., Ahmad, I., Abbasi, M.A., Siddiqui, S.Z., Nafeesa, K., Sattar, A., Ahmed, I., Afzal, S. (2014). Synthesis and Biological Screening of N-(Dimethylphenyl Substituted)-N-Ethyl/Benzyl4-Chlorobenzenesulfonamide Derivatives. Pakistan Journal of Chemistry, 4(4), 153-160. https://doi.org/10.15228/2014.v04.i04.p01

ACS Style
Rehman, A.U.; Ahmad, I.; Abbasi, M.A.; Siddiqui, S.Z.; Nafeesa, K.; Sattar, A.; Ahmed, I.; Afzal, S. Synthesis and Biological Screening of N-(Dimethylphenyl Substituted)-N-Ethyl/Benzyl4-Chlorobenzenesulfonamide Derivatives. Pak. J. Chem. 2014, 4, 153-160. https://doi.org/10.15228/2014.v04.i04.p01

AMA Style
Rehman AU, Ahmad I, Abbasi MA, Siddiqui SZ, Nafeesa K, Sattar A, Ahmed I, Afzal S. Synthesis and Biological Screening of N-(Dimethylphenyl Substituted)-N-Ethyl/Benzyl4-Chlorobenzenesulfonamide Derivatives. Pakistan Journal of Chemistry. 2014; 4(4): 153-160. https://doi.org/10.15228/2014.v04.i04.p01

Chicago/Turabian Style
Rehman, Aziz, Ur, I. Ahmad, M. A. Abbasi, S. Z. Siddiqui, K. Nafeesa, A. Sattar, I. Ahmed, and S. Afzal. 2014. “Synthesis and Biological Screening of N-(Dimethylphenyl Substituted)-N-Ethyl/Benzyl4-Chlorobenzenesulfonamide Derivatives” Pakistan Journal of Chemistry 4, no. 4: 153-160. https://doi.org/10.15228/2014.v04.i04.p01

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