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Research Article | Open Access
Volume 4 | Issue 1 | https://doi.org/10.15228/2014.v04.i01.p05
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Synthesis and Pharmacological Activities of N-(3-Hydroxyphenyl) Benzamide and its 3-O-Derivatives
M.A. Abbasi
Department of Chemistry, Government College University, Lahore-54000, Pakistan
Aziz Ur Rehman
Department of Chemistry, Government College University, Lahore-54000, Pakistan
M. Irshad
Department of Chemistry, Government College University, Lahore-54000, Pakistan
S.Z. Siddiqui
Department of Chemistry, Government College University, Lahore-54000, Pakistan
M. Ashraf
Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan
N-(3-hydroxyphenyl) benzamide (3) was synthesized by the condensation of 3-hydroxyaniline (1) with benzoyl chloride (2) in aqueous medium. From this parent molecule 3, various 3-O-derivatives, 5a-f, were prepared via O-alkylation, by reacting it with different alkyl halides, 4a-f, for 2 h under reflux conditions in the presence of mixture of Na-ethoxide and C2H5OH as solvent. The synthesized compounds were characterized by using different spectroscopic techniques and were subjected to enzyme inhibition activity against butylcholinesterase, acetylcholinesterase, and lipoxygenase enzymes.
How to Cite this paper?
APA-7 Style
Abbasi, M.A., Rehman, A.U., Irshad, M., Siddiqui, S.Z., Ashraf, M. (2014). Synthesis and Pharmacological Activities of N-(3-Hydroxyphenyl) Benzamide and its 3-O-Derivatives. Pakistan Journal of Chemistry, 4(1), 26-30. https://doi.org/10.15228/2014.v04.i01.p05
ACS Style
Abbasi, M.A.; Rehman, A.U.; Irshad, M.; Siddiqui, S.Z.; Ashraf, M. Synthesis and Pharmacological Activities of N-(3-Hydroxyphenyl) Benzamide and its 3-O-Derivatives. Pak. J. Chem. 2014, 4, 26-30. https://doi.org/10.15228/2014.v04.i01.p05
AMA Style
Abbasi MA, Rehman AU, Irshad M, Siddiqui SZ, Ashraf M. Synthesis and Pharmacological Activities of N-(3-Hydroxyphenyl) Benzamide and its 3-O-Derivatives. Pakistan Journal of Chemistry. 2014; 4(1): 26-30. https://doi.org/10.15228/2014.v04.i01.p05
Chicago/Turabian Style
Abbasi, M., A., Aziz Ur Rehman, M. Irshad, S. Z. Siddiqui, and M. Ashraf. 2014. “Synthesis and Pharmacological Activities of N-(3-Hydroxyphenyl) Benzamide and its 3-O-Derivatives” Pakistan Journal of Chemistry 4, no. 1: 26-30. https://doi.org/10.15228/2014.v04.i01.p05
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