Research Article | Open Access Volume 3 | Issue 4 | Paper 01 | https://doi.org/10.15228/2013.v03.i04.p01 |
Synthesis and Antibacterial Activity ofN-(un)substituted-N-((3,4 Methylenedioxyphenyl)methyl) arylsulfonamides
Aziz Ur Rehman
Department of Chemistry, Government College University, Lahore-54000, Pakistan
A. Siddiqa
Department of Chemistry, Government College University, Lahore-54000, Pakistan
M.A. Abbasi
Department of Chemistry, Government College University, Lahore-54000, Pakistan
S. Rasool
Department of Chemistry, Government College University, Lahore-54000, Pakistan
K. Nafeesa
Department of Chemistry, Government College University, Lahore-54000, Pakistan
S. Gul
Department of Chemistry, Government College University, Lahore-54000, Pakistan
I. Ahmed
Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan
S. Afzal
Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan
| Received 29 Apr, 2013 | Accepted 30 Oct, 2013 | Published 02 Dec, 2013 |
ABSTRACT:
Sulfonamides belong to an active group with biological activities and these activities can be enhanced by introducing heterocyclic moiety. N-((3,4-methylenedioxyphenyl)methyl) arylsulfonamides (3a-f) were synthesized by gearing up (3,4- methylenedioxyphenyl)methyl amine (1) and arylsulfonyl chlorides (2a-f) in a weak basic aqueous medium. The target molecules, 6a-f and 7a-f were yielded by the reaction of 3a-f with ethyl iodide (4) and 4-flourobenzyl chloride (5) respectively in a weak basic aprotic polar medium. Structural analysis of the synthesized molecules was processed through the spectral data of IR, 1HNMR, 13C-NMR and EIMS. All the synthesized molecules were evaluated for the antibacterial activity and remained moderately better inhibitors.
How to Cite this paper?
APA-7 Style
Rehman, A.U., Siddiqa, A., Abbasi, M.A., Rasool, S., Nafeesa, K., Gul, S., Ahmed, I., Afzal, S. (2013). Synthesis and Antibacterial Activity ofN-(un)substituted-N-((3,4 Methylenedioxyphenyl)methyl) arylsulfonamides
. Pakistan Journal of Chemistry, 3(4), 142-149. https://doi.org/10.15228/2013.v03.i04.p01
ACS Style
Rehman, A.U.; Siddiqa, A.; Abbasi, M.A.; Rasool, S.; Nafeesa, K.; Gul, S.; Ahmed, I.; Afzal, S. Synthesis and Antibacterial Activity ofN-(un)substituted-N-((3,4 Methylenedioxyphenyl)methyl) arylsulfonamides
. Pak. J. Chem. 2013, 3, 142-149. https://doi.org/10.15228/2013.v03.i04.p01
AMA Style
Rehman AU, Siddiqa A, Abbasi MA, Rasool S, Nafeesa K, Gul S, Ahmed I, Afzal S. Synthesis and Antibacterial Activity ofN-(un)substituted-N-((3,4 Methylenedioxyphenyl)methyl) arylsulfonamides
. Pakistan Journal of Chemistry. 2013; 3(4): 142-149. https://doi.org/10.15228/2013.v03.i04.p01
Chicago/Turabian Style
Rehman, Aziz, Ur, A. Siddiqa, M. A. Abbasi, S. Rasool, K. Nafeesa, S. Gul, I. Ahmed, and S. Afzal. 2013. “Synthesis and Antibacterial Activity ofN-(un)substituted-N-((3,4 Methylenedioxyphenyl)methyl) arylsulfonamides
” Pakistan Journal of Chemistry 3, no. 4: 142-149. https://doi.org/10.15228/2013.v03.i04.p01
This work is licensed under a Creative Commons Attribution 4.0 International License.