Research Article | Open Access Volume 3 | Issue 3 | Paper 06 | https://doi.org/10.15228/2013.v03.i03.p06 |
Nitrated and Brominated Narcotine and its Cleaved Adduct as Butyrylcholinesterase Inhibitors
M.A. Abbasi
Department of Chemistry, Government College University, Lahore-54000, Pakistan
Aziz Ur Rehman
Department of Chemistry, Government College University, Lahore-54000, Pakistan
M. Z. Qureshi
Department of Chemistry, Government College University, Lahore-54000, Pakistan
M.S. Shahid
Department of Chemistry, Government College University, Lahore-54000, Pakistan
S. Rasool
Department of Chemistry, Government College University, Lahore-54000, Pakistan
M. Ashraf
Department of Biochemistry and Biotechnology; Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan
| Received 25 Apr, 2013 | Accepted 26 Oct, 2013 | Published 28 Nov, 2013 |
ABSTRACT:
Narcotine is a very antitussive agent and its modification may lead to some more biological activities. In this presented paper, narcotine (1) was first subjected to nitration and bromination to yield nitrated narcotine (2) and brominated narcotine (3). It was further made to react with phenylchloroformate (6) to give a cleaved addition product 4. This adduct 4 was further nitrated and brominated to yield substituted derivatives 5 and 6, respectively. The structure elucidation of the synthesized compounds was processed via IR, EI-MS and 1H-NMR spectra. These were also screened against butyrylcholinesterase enzyme and were found to the moderate inhibitors of butyrylcholinesterase except nitrated product, 2, of narcotine (1).
How to Cite this paper?
APA-7 Style
Abbasi, M.A., Rehman, A.U., Qureshi, M.Z., Shahid, M.S., Rasool, S., Ashraf, M. (2013). Nitrated and Brominated Narcotine and its Cleaved Adduct as Butyrylcholinesterase Inhibitors
. Pakistan Journal of Chemistry, 3(3), 129-133. https://doi.org/10.15228/2013.v03.i03.p06
ACS Style
Abbasi, M.A.; Rehman, A.U.; Qureshi, M.Z.; Shahid, M.S.; Rasool, S.; Ashraf, M. Nitrated and Brominated Narcotine and its Cleaved Adduct as Butyrylcholinesterase Inhibitors
. Pak. J. Chem. 2013, 3, 129-133. https://doi.org/10.15228/2013.v03.i03.p06
AMA Style
Abbasi MA, Rehman AU, Qureshi MZ, Shahid MS, Rasool S, Ashraf M. Nitrated and Brominated Narcotine and its Cleaved Adduct as Butyrylcholinesterase Inhibitors
. Pakistan Journal of Chemistry. 2013; 3(3): 129-133. https://doi.org/10.15228/2013.v03.i03.p06
Chicago/Turabian Style
Abbasi, M., A., Aziz Ur Rehman, M. Z. Qureshi, M. S. Shahid, S. Rasool, and M. Ashraf. 2013. “Nitrated and Brominated Narcotine and its Cleaved Adduct as Butyrylcholinesterase Inhibitors
” Pakistan Journal of Chemistry 3, no. 3: 129-133. https://doi.org/10.15228/2013.v03.i03.p06
This work is licensed under a Creative Commons Attribution 4.0 International License.