Antibacterial Activities of Newly Synthesized Azo Anils And its Oxalato-Bridged Binuclear {Cu(II) and Zn(II)} Complexes

ABSTRACT:

Novel oxalato-bridged binuclear metal {Cu(II) and Zn(II)} complexes; [{(L₁)M(II)}₂OX] (L₁= 2-({2-hydroxy-5-[(4- nitrophenyl)diazenyl]benzylidene}amino)benzoic acid, OX = oxalate) and [{(L₂)M(II)}₂OX], (L₂ = 2-{[(2- hydroxyphenyl)imino]methyl}-4-[(4-nitrophenyl)diazenyl] phenol, OX = oxalate) were synthesized. Azo anils and corresponding Metal {Cu((II) and Zn(II)} complexes were characterised by Elemental Combustion System, Atomic Absorption Spectroscopy (AAS), Fourier Transform Infrared (FTIR) spectroscopy, UV-Visible, Spectroscopy and ¹³C¹H-Nuclear Magnetic Resonance spectroscopy. Elemental Analyses, FTIR and UV-Vis were used for structural characterization of metal complexes and distorted octahedral geometry for M(II) complexes came into being. The antibacterial activities of azo anils ligands, oxalate ion, CuCl₂.2H₂O, Zn(CH₃COO)₂.2H₂O and metal {Cu(II) and Zn(II)} complexes against gram-positive (Bacillis subtilis) and gramnegative (Escherichia coli) were evaluated. The antibacterial activities were performed to asses inhibition potential of ligand and their metal {Cu(II) and Zn(II)} complexes. The results revealed that antibacterial activities of azo anils become more pronounced when free ligands were coordinated to central metal atom.