Research Article | Open Access Volume 4 | Issue 4 | Paper 02 | doi.org/10.15228/2014.v04.i04.p02 |
M.A. Abbasi
Department of Chemistry, Government College University, Lahore, Pakistan
U. Mujahid
Department of Chemistry, Government College University, Lahore, Pakistan
Aziz Ur Rehman
Department of Chemistry, Government College University, Lahore, Pakistan
S. Rasool
Department of Chemistry, Government College University, Lahore, Pakistan
K. M. Khan
HEJ, Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan
M. Ashraf
Department of Biochemistry and Biotechnology; The Islamia University of Bahawalpur, Pakistan
| Received 03 Mar, 2014 | Accepted 25 Nov, 2014 | Published 05 Dec, 2014 |
ABSTRACT:
Sulfonamides belong to an emerging class having good inhibitory effects. In the present work, a series of N-substituted derivatives of N-benzyl-4-chlorobenzenesulfonamide have been synthesized. The reaction of moringine (benzylamine; 1) with 4- chlorobenzenesulfonyl chloride (2) in aqueous medium yielded the parent molecule, N-benzyl-4-chlorobenzenesulfonamide (3). Alkyl/aralkyl halides, 4a-m, were reacted with 3 in polar aprotic medium to produce N-substituted derivatives, 5a-m. These synthesized products were characterized by 1H-NMR, IR and EI-MS spectra and screened against lipoxygenase (LOX) enzyme. These were found to be moderate inhibitors of this enzyme and could find their use as therapeutic agent for various inflammatory ailments.
How to Cite this paper?
APA-7 Style
Abbasi, M.A., Mujahid, U., Rehman, A.U., Rasool, S., Khan, K.M., Ashraf, M. (2014). Synthesis of Some N-Substituted Sulfonamides Derived from Moringine as Lipoxygenase Inhibitors
. Pakistan Journal of Chemistry, 4(4), 161-166. https://doi.org/10.15228/2014.v04.i04.p02
ACS Style
Abbasi, M.A.; Mujahid, U.; Rehman, A.U.; Rasool, S.; Khan, K.M.; Ashraf, M. Synthesis of Some N-Substituted Sulfonamides Derived from Moringine as Lipoxygenase Inhibitors
. Pak. J. Chem. 2014, 4, 161-166. https://doi.org/10.15228/2014.v04.i04.p02
AMA Style
Abbasi MA, Mujahid U, Rehman AU, Rasool S, Khan KM, Ashraf M. Synthesis of Some N-Substituted Sulfonamides Derived from Moringine as Lipoxygenase Inhibitors
. Pakistan Journal of Chemistry. 2014; 4(4): 161-166. https://doi.org/10.15228/2014.v04.i04.p02
Chicago/Turabian Style
Abbasi, M., A., U. Mujahid, Aziz Ur Rehman, S. Rasool, K. M. Khan, and M. Ashraf. 2014. “Synthesis of Some N-Substituted Sulfonamides Derived from Moringine as Lipoxygenase Inhibitors
” Pakistan Journal of Chemistry 4, no. 4: 161-166. https://doi.org/10.15228/2014.v04.i04.p02
This work is licensed under a Creative Commons Attribution 4.0 International License.