Research Article | Open Access Volume 4 | Issue 3 | Paper 06 | doi.org/10.15228/2014.v04.i03.p06 |
M. Asif
Department of Pharmacy, GRD (PG) IMT, Dehradun, India
| Received 30 Apr, 2014 | Accepted 15 Sep, 2014 | Published 10 Oct, 2014 |
ABSTRACT:
The modification of the isoniazid (INH) structure and with N-substituted 5-(pyridine-4-yl)-1,3,4-oxadiazole-2-amine, 5-(pyridin4-yl)-1,3,4-oxadiazol-2-amine derivatives were evaluated in vitro for their anti-tubercular (anti-TB) activity against M. tuberculosis H37Rv, M. avium, M. kansasii and one clinical isolated strain of M. kansasii. 2-Isonicotinoyl-N-(4-octylphenyl) hydrazinecarboxamide displayed an in vitro efficacy comparable to that of INH for M. tuberculosis with MIC of 1–2 μM. Among the halogenated derivatives, the best anti-TB activity was found for 2-isonicotinoyl-N-(2,4,6-trichlorophenyl) hydrazine carboxamide (MIC=4μM). Most of the hydrazinecarboxamides exhibited significant activity against INH-resistant non tuberculous mycobacteria. Two other series of N´-(E)-heteroaromatic-isonicotino hydrazide derivatives and 1-(7-chloroquinolin4-yl)-2-[(heteroaromatic)methylene] hydrazone derivatives have been for their in vitro anti-TB activity against M. tuberculosis H37Rv. Several compounds were non cytotoxic and exhibited significant MIC value (3.12, 2.50, 1.25, or 0.60 μg/mL) compared with ethambutol (3.12 μg/mL) and rifampicin (2.0 μg/ml). These results can be considered an important point for the rational design of new leads for anti-TB compounds.
How to Cite this paper?
APA-7 Style
Asif, M. (2014). A Review on Antitubercular Activity of Some 2-isonicotinoylhydrazinecarboxamide, 5-(pyridin-4-yl)- 1,3,4-oxadiazol-2-amine, N´-(E)-heteroaromatic-isonicotino-hydrazide and 1-(7-chloroquinolin-4-yl)- 2-(heteroaromatic)methylene hydrazone derivatives
. Pakistan Journal of Chemistry, 4(3), 132-141. https://doi.org/10.15228/2014.v04.i03.p06
ACS Style
Asif, M. A Review on Antitubercular Activity of Some 2-isonicotinoylhydrazinecarboxamide, 5-(pyridin-4-yl)- 1,3,4-oxadiazol-2-amine, N´-(E)-heteroaromatic-isonicotino-hydrazide and 1-(7-chloroquinolin-4-yl)- 2-(heteroaromatic)methylene hydrazone derivatives
. Pak. J. Chem. 2014, 4, 132-141. https://doi.org/10.15228/2014.v04.i03.p06
AMA Style
Asif M. A Review on Antitubercular Activity of Some 2-isonicotinoylhydrazinecarboxamide, 5-(pyridin-4-yl)- 1,3,4-oxadiazol-2-amine, N´-(E)-heteroaromatic-isonicotino-hydrazide and 1-(7-chloroquinolin-4-yl)- 2-(heteroaromatic)methylene hydrazone derivatives
. Pakistan Journal of Chemistry. 2014; 4(3): 132-141. https://doi.org/10.15228/2014.v04.i03.p06
Chicago/Turabian Style
Asif, M.. 2014. “A Review on Antitubercular Activity of Some 2-isonicotinoylhydrazinecarboxamide, 5-(pyridin-4-yl)- 1,3,4-oxadiazol-2-amine, N´-(E)-heteroaromatic-isonicotino-hydrazide and 1-(7-chloroquinolin-4-yl)- 2-(heteroaromatic)methylene hydrazone derivatives
” Pakistan Journal of Chemistry 4, no. 3: 132-141. https://doi.org/10.15228/2014.v04.i03.p06
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