Research Article | Open Access Volume 4 | Issue 3 | Paper 01 | doi.org/10.15228/2014.v04.i03.p01 |
S. Nadeem
Department of Chemistry, School of Science and Technology, University of Management & Technology, Lahore, Pakistan
Aziz Ur Rehman
Department of Chemistry, Government College University, Lahore-54000, Pakistan
M.A. Abbasi
Department of Chemistry, Government College University, Lahore-54000, Pakistan
S.Z. Siddiqui
Department of Chemistry, Government College University, Lahore-54000, Pakistan
S. Rasool
Department of Chemistry, Government College University, Lahore-54000, Pakistan
I. Ahmad
Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
S. Afzal
Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
| Received 15 May, 2014 | Accepted 20 Aug, 2014 | Published 25 Aug, 2014 |
ABSTRACT:
The molecules bearing azomethine group are known to possess biological activities. In the present work, the synthesis of N’– Substitutedbenzylidene-2-(2, 4-dimethylphenoxy) acetatohydrazide (5a-d) has been elaborated using 2,4-Dimethylphenol (1) as precursor. The molecule, 1, was converted to ethyl 2-(2,4-dimethylphenoxy)acetate (2) on refluxing with ethyl 2-bromoacetate in ethanol in the presence of KOH. Ethyl ester, 2, was refluxed with hydrated hydrazine (80%) in ethanol to yield 2-(2,4- dimethylphenoxy) acetohydrazide (3). The target molecules, 5a-d, were synthesized by stirring 3 with phenyl/aryl carboxaldehyde (4a-d) in methanol in the presence of glacial acetic acid. The synthesized molecules were characterized by spectral data and evaluated for antibacterial and anti-enzymatic activities.
How to Cite this paper?
APA-7 Style
Nadeem, S., Rehman, A.U., Abbasi, M.A., Siddiqui, S.Z., Rasool, S., Ahmad, I., Afzal, S. (2014). Antibacterial and Enzyme Inhibition Studies of N‘-Substituted Benzylidene-2-(2, 4-Dimethylphenoxy) Acetatohydrazides
. Pakistan Journal of Chemistry, 4(3), 96-100. https://doi.org/10.15228/2014.v04.i03.p01
ACS Style
Nadeem, S.; Rehman, A.U.; Abbasi, M.A.; Siddiqui, S.Z.; Rasool, S.; Ahmad, I.; Afzal, S. Antibacterial and Enzyme Inhibition Studies of N‘-Substituted Benzylidene-2-(2, 4-Dimethylphenoxy) Acetatohydrazides
. Pak. J. Chem. 2014, 4, 96-100. https://doi.org/10.15228/2014.v04.i03.p01
AMA Style
Nadeem S, Rehman AU, Abbasi MA, Siddiqui SZ, Rasool S, Ahmad I, Afzal S. Antibacterial and Enzyme Inhibition Studies of N‘-Substituted Benzylidene-2-(2, 4-Dimethylphenoxy) Acetatohydrazides
. Pakistan Journal of Chemistry. 2014; 4(3): 96-100. https://doi.org/10.15228/2014.v04.i03.p01
Chicago/Turabian Style
Nadeem, S., Aziz Ur Rehman, M. A. Abbasi, S. Z. Siddiqui, S. Rasool, I. Ahmad, and S. Afzal. 2014. “Antibacterial and Enzyme Inhibition Studies of N‘-Substituted Benzylidene-2-(2, 4-Dimethylphenoxy) Acetatohydrazides
” Pakistan Journal of Chemistry 4, no. 3: 96-100. https://doi.org/10.15228/2014.v04.i03.p01
This work is licensed under a Creative Commons Attribution 4.0 International License.