Research Article | Open Access Volume 4 | Issue 1 | Paper 02 | doi.org/10.15228/2014.v04.i02.p02 |
Aziz-ur-Rehman
Department of Chemistry, Government College University, Lahore-54000, Pakistan
S. Rasool
HEJ Research Institute of Chemistry, ICCBS, University of Karachi, Karachi-75270, Pakistan
M. A. Abbasi
HEJ Research Institute of Chemistry, ICCBS, University of Karachi, Karachi-75270, Pakistan
K. M. Khan
HEJ Research Institute of Chemistry, ICCBS, University of Karachi, Karachi-75270, Pakistan
I. Ahmad
Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan
S. Afzal
Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan
| Received 06 Apr, 2014 | Accepted 17 May, 2014 | Published 25 May, 2014 |
ABSTRACT:
Tetrahydrofuran-2-ylmethylamine (1) was subjected to condensation reaction with 4-chlorobenzenesulfonyl chloride (2) in a mild basic medium to synthesize N-(tetrahydrofuran-2-ylmethyl)-4-chlorobenzenesulfonamide (3). A series of N-substituted derivatives, 5a-f, were synthesized by condensing alkyl/aralkyl halides, 4a-f, with 3 under polar aprotic conditions using sodium hydride activator. The spectral characterization of all the molecules included IR, 1H-NMR and EI-MS data. The biological activity evaluation rendered 5c as moderate inhibitor of all the bacterial strains.
How to Cite this paper?
MLA
Rasool, S., et al. “Synthesis, Spectral Characterization and biological activity of N-Substituted Derivatives of Tetrahydrofuran-2-ylmethylamine.” Pakistan Journal of Chemistry 4.2 (2014).
https://doi.org/10.15228/2014.v04.i02.p02
APA
Rasool, S., Abbasi, M. A., Khan, K. M., Ahmad, I., & Afzal, S. (2014). Synthesis, Spectral Characterization and biological activity of N-Substituted Derivatives of Tetrahydrofuran-2-ylmethylamine. Pakistan Journal of Chemistry, 4(2).
https://doi.org/10.15228/2014.v04.i02.p02
Chicago
Rasool, S., M. A. Abbasi, K. M. Khan, I. Ahmad, and S. Afzal. “Synthesis, Spectral Characterization and biological activity of N-Substituted Derivatives of Tetrahydrofuran-2-ylmethylamine.” Pakistan Journal of Chemistry 4, no. 2 (2014). https://doi.org/10.15228/2014.v04.i02.p02
Harvard
Rasool, S., Abbasi, M.A., Khan, K.M., Ahmad, I. and Afzal, S., 2014. Synthesis, Spectral Characterization and biological activity of N-Substituted Derivatives of Tetrahydrofuran-2-ylmethylamine. Pakistan Journal of Chemistry, 4(2). https://doi.org/10.15228/2014.v04.i02.p02
Vancouver
Rasool S, Abbasi MA, Khan KM, Ahmad I, Afzal S. Synthesis, Spectral Characterization and biological activity of N-Substituted Derivatives of Tetrahydrofuran-2-ylmethylamine. Pakistan Journal of Chemistry. 2014 Jun 1;4(2).
https://doi.org/10.15228/2014.v04.i02.p02
This work is licensed under a Creative Commons Attribution 4.0 International License.