Research Article | Open Access Volume 4 | Issue 1 | Paper 02 | doi.org/10.15228/2014.v04.i01.p02 |
Aziz Ur Rehman
Department of Chemistry, Government College University, Lahore, Pakistan
M. Arfan
Department of Chemistry, Government College University, Lahore, Pakistan
M.A. Abbasi
Department of Chemistry, Government College University, Lahore, Pakistan
S. Rasool
Department of Chemistry, Government College University, Lahore, Pakistan
K. Rubab
Department of Chemistry, Government College University, Lahore, Pakistan
G. Hussain
Department of Chemistry, Government College University, Lahore, Pakistan
I. Ahmed
Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Pakistan
S. Afzal
Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Pakistan
| Received 06 Aug, 2013 | Accepted 17 Feb, 2014 | Published 25 Feb, 2014 |
ABSTRACT:
The two step synthesis of a series of N-substituted derivatives of N-(4-Methylpyridin-2-yl) benzenesulfonamide with potential antibacterial activity, has been reported. First step includes the synthesis of N-(4-Methylpyridin-2-yl) benzenesulfonamide (3) by reaction of 2-Amino-4-methylpyridine (1) and Benzenesulfonyl chloride (2) in a slightly basic aqueous medium. The molecule 3 was converted to N-Alkyl/aralkyl-N-(4-methylpyridin-2-yl) benzenesulfonamide derivatives, 5a-f, on treatment with alkyl/aralkyl halides, 4a-f, using lithium hydride as activator in N,N-dimethylformamide. The synthesized molecules were well corroborated by 1H-NMR, IR and EI-MS spectral data and evaluated for antibacterial activity against four gram-negative and two gram-positive bacteria. The evaluation results rendered these compounds as moderately good inhibitors and may be employed as therapeutic agent for certain inflammatory ailments.
How to Cite this paper?
APA-7 Style
Rehman, A.U., Arfan, M., Abbasi, M.A., Rasool, S., Rubab, K., Hussain, G., Ahmed, I., Afzal, S. (2014). Synthesis and Screening of Some New N-Substituted Derivatives of N-(4-Methylpyridin-2-yl) benzenesulfonamides as Potential Antibacterial Agents. Pakistan Journal of Chemistry, 4(1), 6-11. https://doi.org/10.15228/2014.v04.i01.p02
ACS Style
Rehman, A.U.; Arfan, M.; Abbasi, M.A.; Rasool, S.; Rubab, K.; Hussain, G.; Ahmed, I.; Afzal, S. Synthesis and Screening of Some New N-Substituted Derivatives of N-(4-Methylpyridin-2-yl) benzenesulfonamides as Potential Antibacterial Agents. Pak. J. Chem. 2014, 4, 6-11. https://doi.org/10.15228/2014.v04.i01.p02
AMA Style
Rehman AU, Arfan M, Abbasi MA, Rasool S, Rubab K, Hussain G, Ahmed I, Afzal S. Synthesis and Screening of Some New N-Substituted Derivatives of N-(4-Methylpyridin-2-yl) benzenesulfonamides as Potential Antibacterial Agents. Pakistan Journal of Chemistry. 2014; 4(1): 6-11. https://doi.org/10.15228/2014.v04.i01.p02
Chicago/Turabian Style
Rehman, Aziz, Ur, M. Arfan, M. A. Abbasi, S. Rasool, K. Rubab, G. Hussain, I. Ahmed, and S. Afzal. 2014. “Synthesis and Screening of Some New N-Substituted Derivatives of N-(4-Methylpyridin-2-yl) benzenesulfonamides as Potential Antibacterial Agents” Pakistan Journal of Chemistry 4, no. 1: 6-11. https://doi.org/10.15228/2014.v04.i01.p02
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