Research Article | Open Access Volume 3 | Issue 4 | Paper 02 | doi.org/10.15228/2013.v03.i04.p02 |
P.P. SriKumar
Department of Pharmaceutical Chemistry, Hindu College of Pharmacy, Amaravathi Road, Guntur 522 002, India
T.S. Lakshmi
Department of Pharmaceutical Chemistry, Hindu College of Pharmacy, Amaravathi Road, Guntur 522 002, India
K. Sekhar
Department of Pharmaceutical Chemistry, Hindu College of Pharmacy, Amaravathi Road, Guntur 522 002, India
| Received 09 Jul , 2013 | Accepted 27 Sep, 2013 | Published 10 Nov, 2013 |
ABSTRACT:
A new series of substituted 5, 6, 7, 8 tetrahydro quinazoline derivative has been synthesized from a mixture of methyl/ethylacetoacetate with different substituted aromatic/ hetero aromatic aldehydes. Then treated with aminoguanidines / thiourea afforded 2-hydrizino substituted 5, 6, 7, 8-tetrahydro quinazoline (D1-8)/ 2-mercapto substituted 5, 6, 7, 8-tetrahydro quinazoline derivatives (E1-8). The structures of newly synthesized compounds were confirmed by spectral data (IR, H1NMR, C 13NMR, Mass spectra and Elemental analysis).The synthesized compounds were also evaluated for their anthelimentic activity using earth worms of nearly equal size (8 cm±1) were selected randomly for present study and Albendazole was used as reference standard. The compounds which contains Cl and F groups substituted at Para position on phenyl ring at C5 of substituted 5, 6, 7, 8 tetrahydro quinazoline derivatives showed good activity when compared with reference standard.
How to Cite this paper?
APA-7 Style
SriKumar, P.P., Lakshmi, T.S., Sekhar, K. (2013). Synthesis of Some New 2-Mercapto/Hydrizino 5, 6, 7, 8 – Tetrahydro Quinazoline Derivatives as In-Vitro Anthelimentic Agents
. Pakistan Journal of Chemistry, 3(4), 150-155. https://doi.org/10.15228/2013.v03.i04.p02
ACS Style
SriKumar, P.P.; Lakshmi, T.S.; Sekhar, K. Synthesis of Some New 2-Mercapto/Hydrizino 5, 6, 7, 8 – Tetrahydro Quinazoline Derivatives as In-Vitro Anthelimentic Agents
. Pak. J. Chem. 2013, 3, 150-155. https://doi.org/10.15228/2013.v03.i04.p02
AMA Style
SriKumar PP, Lakshmi TS, Sekhar K. Synthesis of Some New 2-Mercapto/Hydrizino 5, 6, 7, 8 – Tetrahydro Quinazoline Derivatives as In-Vitro Anthelimentic Agents
. Pakistan Journal of Chemistry. 2013; 3(4): 150-155. https://doi.org/10.15228/2013.v03.i04.p02
Chicago/Turabian Style
SriKumar, P., P., T. S. Lakshmi, and K. Sekhar. 2013. “Synthesis of Some New 2-Mercapto/Hydrizino 5, 6, 7, 8 – Tetrahydro Quinazoline Derivatives as In-Vitro Anthelimentic Agents
” Pakistan Journal of Chemistry 3, no. 4: 150-155. https://doi.org/10.15228/2013.v03.i04.p02
This work is licensed under a Creative Commons Attribution 4.0 International License.