Research Article | Open Access Volume 3 | Issue 3 | Paper 02 | doi.org/10.15228/2013.v03.i03.p02 |
Aziz Ur Rehman
Department of Chemistry, Government College University, Lahore-54000, Pakistan
A. Siddiqa
Department of Chemistry, Government College University, Lahore-54000, Pakistan
M.A. Abbasi
Department of Chemistry, Government College University, Lahore-54000, Pakistan
S. Rasool
Department of Chemistry, Government College University, Lahore-54000, Pakistan
S.Z. Siddiqui
Department of Chemistry, Government College University, Lahore-54000, Pakistan
S. Gul
Department of Chemistry, Government College University, Lahore-54000, Pakistan
M. Ashraf
Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan
R. Nasar
Department of Pharmacy; The Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan
| Received 24 Apr, 2013 | Accepted 04 Aug, 2013 | Published 10 Aug, 2013 |
ABSTRACT:
Organic synthesis of various compounds followed by biological activities is the going on methodology in the world for pharmacological evaluation. The undertaken research is the synthesis of N-(3-ethoxyphenyl)-4-methylbenzenesulfonamide (3) through condensation reaction of m-phenetidine (1) and 4-methylbenzenesulfonyl chloride (2) using basic aqueous media of sodium carbonate. Further, the synthesized compound 3 was reacted with different alkyl/aralkyl halides (4a-j) using DMF as aprotic polar solvent and NaH as a base to yield 5a-j compounds. The synthesized molecules were characterized from their spectral data. The synthesized compounds were evaluated against cholinesterase (AChE and BChE), lipoxygenase (LOX), urease, chymotrypsin and tyrosinase enzymes; and found to be the moderate inhibitor against tyrosinase enzyme.
How to Cite this paper?
APA-7 Style
Rehman, A.U., Siddiqa, A., Abbasi, M.A., Rasool, S., Siddiqui, S.Z., Gul, S., Ashraf, M., Nasar, R. (2013). Enzyme Inhibition Studies on N-Substituted Sulfonamides Derived from m-phenetidine. Pakistan Journal of Chemistry, 3(3), 100-106. https://doi.org/10.15228/2013.v03.i03.p02
ACS Style
Rehman, A.U.; Siddiqa, A.; Abbasi, M.A.; Rasool, S.; Siddiqui, S.Z.; Gul, S.; Ashraf, M.; Nasar, R. Enzyme Inhibition Studies on N-Substituted Sulfonamides Derived from m-phenetidine. Pak. J. Chem. 2013, 3, 100-106. https://doi.org/10.15228/2013.v03.i03.p02
AMA Style
Rehman AU, Siddiqa A, Abbasi MA, Rasool S, Siddiqui SZ, Gul S, Ashraf M, Nasar R. Enzyme Inhibition Studies on N-Substituted Sulfonamides Derived from m-phenetidine. Pakistan Journal of Chemistry. 2013; 3(3): 100-106. https://doi.org/10.15228/2013.v03.i03.p02
Chicago/Turabian Style
Rehman, Aziz, Ur, A. Siddiqa, M. A. Abbasi, S. Rasool, S. Z. Siddiqui, S. Gul, M. Ashraf, and R. Nasar. 2013. “Enzyme Inhibition Studies on N-Substituted Sulfonamides Derived from m-phenetidine” Pakistan Journal of Chemistry 3, no. 3: 100-106. https://doi.org/10.15228/2013.v03.i03.p02
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