Research Article | Open Access Volume 3 | Issue 2 | Paper 03 | doi.org/10.15228/2013.v03.i02.p03 |
Aziz Ur Rehman
Department of Chemistry, Government College University, Lahore-54000, Pakistan
K. Nafeesa
Department of Chemistry, Government College University, Lahore-54000, Pakistan
M.A. Abbasi
Department of Chemistry, Government College University, Lahore-54000, Pakistan
H. Kashfa
Department of Chemistry, Government College University, Lahore-54000, Pakistan
S. Rasool
Department of Chemistry, Government College University, Lahore-54000, Pakistan
I. Ahmad
Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan
S. Arshad
Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan
| Received 02 Mar, 2013 | Accepted 21 Mar, 2013 | Published 15 Apr, 2013 |
ABSTRACT:
In the presented research work, a series of S-substituted derivatives of 5-(3-nitrophenyl)-1,3,4-Oxadiazole-2-thiol was synthesized from 3-nitrobenzoic acid. The synthesis was carried out by converting 3-nitrobenzoic acid correspondingly into ester, hydrazide and 5-(3-nitrophenyl)-1,3,4-Oxadiazole-2-thiol (4). Finally, the S-substituted derivatives (6a-m) were brought about by reacting 5- (3-nitrophenyl)-1,3,4-Oxadiazole-2-thiol with different electrophiles (5a-m) in the presence of NaH and N,N-dimethylformamide. Structure elucidation for all the synthesized compounds was executed by different spectroscopic analysis like IR, 1H-NMR and EI-MS. All the synthesized derivatives were screened for antibacterial activity. Antibacterial potential was sorted out for four gram-negative bacteria including Shigella sonnei, Escherichia coli, Pseudomonas aeruginosa & Salmonella typhi; and two grampositive bacteria including Bacillus subtilis & Staphylococcus aureus and found results that most of the compounds exhibit significant activity relative to the standard drugs Ciprofloxacin and Gentamycin.
How to Cite this paper?
APA-7 Style
Rehman, A.U., Nafeesa, K., Abbasi, M.A., Kashfa, H., Rasool, S., Ahmad, I., Arshad, S. (2013). Synthesis, Characterization and Biological Screening of Various S-substituted Derivatives of 5-(3-Nitrophenyl)-1,3,4-Oxadiazole-2-thiol . Pakistan Journal of Chemistry, 3(2), 56-63. https://doi.org/10.15228/2013.v03.i02.p03
ACS Style
Rehman, A.U.; Nafeesa, K.; Abbasi, M.A.; Kashfa, H.; Rasool, S.; Ahmad, I.; Arshad, S. Synthesis, Characterization and Biological Screening of Various S-substituted Derivatives of 5-(3-Nitrophenyl)-1,3,4-Oxadiazole-2-thiol . Pak. J. Chem. 2013, 3, 56-63. https://doi.org/10.15228/2013.v03.i02.p03
AMA Style
Rehman AU, Nafeesa K, Abbasi MA, Kashfa H, Rasool S, Ahmad I, Arshad S. Synthesis, Characterization and Biological Screening of Various S-substituted Derivatives of 5-(3-Nitrophenyl)-1,3,4-Oxadiazole-2-thiol . Pakistan Journal of Chemistry. 2013; 3(2): 56-63. https://doi.org/10.15228/2013.v03.i02.p03
Chicago/Turabian Style
Rehman, Aziz, Ur, K. Nafeesa, M. A. Abbasi, H. Kashfa, S. Rasool, I. Ahmad, and S. Arshad. 2013. “Synthesis, Characterization and Biological Screening of Various S-substituted Derivatives of 5-(3-Nitrophenyl)-1,3,4-Oxadiazole-2-thiol ” Pakistan Journal of Chemistry 3, no. 2: 56-63. https://doi.org/10.15228/2013.v03.i02.p03
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