{"id":4106,"date":"2026-05-04T18:53:59","date_gmt":"2026-05-04T18:53:59","guid":{"rendered":"https:\/\/chempublishers.com\/advances-of-nutrition-science-and-technology\/?p=4106"},"modified":"2026-05-07T05:39:41","modified_gmt":"2026-05-07T05:39:41","slug":"anst-0626","status":"publish","type":"post","link":"https:\/\/chempublishers.com\/advances-of-nutrition-science-and-technology\/2026\/05\/04\/anst-0626\/","title":{"rendered":"Genetic Regulation of Vitamin C Transport: The Role of SLC23A1 in Nutrient Metabolism, Antioxidant Defense, and Human Health"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"4106\" class=\"elementor elementor-4106\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a8e43e2 e-flex e-con-boxed e-con e-parent\" data-id=\"a8e43e2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-c3d3b6e e-con-full e-flex e-con e-child\" data-id=\"c3d3b6e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2497e9c elementor-widget elementor-widget-text-editor\" data-id=\"2497e9c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<table border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\"><tbody><tr><td><div><strong>Review Article | Open Access<\/strong><\/div><div class=\"item doi\"><span class=\"value\">Volume 6 | Issue 01-2\u00a0 | Paper 06 |\u00a0 <a href=\"https:\/\/chempublishers.com\/advances-of-nutrition-science-and-technology\/wp-content\/uploads\/sites\/3\/2026\/05\/ANST.v06.i1-2.p6.pdf\">https:\/\/doi.org\/10.15228\/ANST.2026.v06.i01-2.p06<\/a><\/span><\/div><\/td><\/tr><\/tbody><\/table><h4><strong><b>Genetic Regulation of Vitamin C Transport: The Role of SLC23A1 in Nutrient Metabolism, Antioxidant Defense, and Human Health<\/b><\/strong><\/h4><div class=\"row\"><div class=\"main_entry\"><p><strong>Sarah Usmani<\/strong><br \/>Department of Biological Sciences, California State University, Long Beach, 1250 Bellflower Blvd, MS 9502, Long Beach, CA 90840-9502, USA<\/p><p><strong>Fiona Caldwell<\/strong><br \/>Department of Biological Sciences, California State University, Long Beach, 1250 Bellflower Blvd, MS 9502, Long Beach, CA 90840-9502, USA<\/p><p><strong>Audrey Silva<\/strong><br \/>Department of Biological Sciences, California State University, Long Beach, 1250 Bellflower Blvd, MS 9502, Long Beach, CA 90840-9502, USA<\/p><p><strong>Myra Assaad<\/strong><br \/>Department of Biological Sciences, California State University, Long Beach, 1250 Bellflower Blvd, MS 9502, Long Beach, CA 90840-9502, USA<\/p><p><a href=\"https:\/\/orcid.org\/0009-0005-5009-2702\" target=\"_blank\" rel=\"noopener\"><strong>Nicole Sandoval<\/strong><\/a><br \/>Department of Biological Sciences, California State University, Long Beach, 1250 Bellflower Blvd, MS 9502, Long Beach, CA 90840-9502, USA<\/p><p><strong>Joshua Guardado<\/strong><br \/>Department of Biological Sciences, California State University, Long Beach, 1250 Bellflower Blvd, MS 9502, Long Beach, CA 90840-9502, USA<\/p><table border=\"0\" width=\"93%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\"><tbody><tr><td align=\"center\" valign=\"top\"><strong>Received<\/strong><br \/>24 Mar, 2026<\/td><td align=\"center\" valign=\"top\"><strong>Accepted<\/strong><br \/>28 Apr, 2026<\/td><td align=\"center\" valign=\"top\"><strong>Published<\/strong><br \/>4 May, 2026<\/td><\/tr><\/tbody><\/table><div class=\"item abstract\"><p align=\"justify\"><strong>ABSTRACT:<\/strong><\/p><p>Vitamin C is an essential micronutrient responsible for antioxidant defense, collagen synthesis, and immune regulation. It enters cells through Sodium-Dependent Vitamin C Transporter 1 (SVCT1) and Sodium-Dependent Vitamin C Transporter 2 (SVCT2), which are produced from Solute Carrier Family 23 Member 1 (SLC23A1) and Solute Carrier Family 23 Member 2 (SLC23A2) genes. Among these, SLC23A1 plays a key role in the absorption and reabsorption of vitamin C in epithelial tissues. Genetic variations can affect vitamin C status, potentially contributing to chronic disease risk. SLC23A1 is closely linked to vitamin C homeostasis, as changes in its expression can affect the efficiency of vitamin C absorption and utilization. This review examines the molecular mechanisms of SLC23A1-mediated vitamin C transport, its role in nutrient metabolism, and the implications of genetic variation for human health, while providing critical insights into food and nutritional science based on SLC23A1 gene expression. SLC23A1 and vitamin C work together in health processes, antioxidant defenses, and metabolism to support the body&#8217;s function. Understanding the regulation of SLC23A1 may improve nutritional approaches to modulate antioxidant levels and prevent chronic disease.<\/p><p><strong><b>Keywords:<\/b><\/strong>\u00a0Vitamin C, SLC23A1, Diet, Nutrigenomic, Antioxidant<\/p><p><strong>How to Cite this paper?<\/strong><\/p><\/div><div class=\"item abstract\"><div class=\"csl-entry\"><p><strong>APA-7 Style<\/strong><br \/>Usmani S., Caldwell F., Silva A., Assaad M., Sandoval N., Guardado J., (2026) Genetic Regulation of Vitamin C Transport: The Role of SLC23A1 in Nutrient Metabolism, Antioxidant Defense, and Human Health<em><i>\u00a0<\/i><\/em><a href=\"https:\/\/chempublishers.com\/advances-of-nutrition-science-and-technology\/wp-content\/uploads\/sites\/3\/2026\/05\/ANST.v06.i1-2.p6.pdf\" target=\"_blank\" rel=\"noopener\"><em>Journal Advances of Nutrition Science and Technology<\/em>, 6(1-2), 35-45<\/a>. https:\/\/doi.org\/10.15228\/ANST.2026.v06.i01-2.p06<\/p><p><strong>ACS Style<\/strong><br \/>S. Usmani, F. Caldwell, A. Silva, M. Assaad, N. Sandoval, J. Guardado <em>Genetic Regulation of Vitamin C Transport: The Role of SLC23A1 in Nutrient Metabolism, Antioxidant Defense, and Human Health<i>\u00a0<\/i><\/em><a href=\"https:\/\/chempublishers.com\/advances-of-nutrition-science-and-technology\/wp-content\/uploads\/sites\/3\/2026\/05\/ANST.v06.i1-2.p6.pdf\" target=\"_blank\" rel=\"noopener\"><em>Journal Advances of Nutrition Science and Technology<\/em>, 6(1-2), 35-45<\/a>. https:\/\/doi.org\/10.15228\/ANST.2026.v06.i01-2.p06<\/p><p><strong>AMA Style<\/strong><br \/>S. Usmani; F. Caldwell; A. Silva; M. Assaad; N. Sandoval; J. Guardado; Genetic Regulation of Vitamin C Transport: The Role of SLC23A1 in Nutrient Metabolism, Antioxidant Defense, and Human Health\u00a0<a href=\"https:\/\/chempublishers.com\/advances-of-nutrition-science-and-technology\/wp-content\/uploads\/sites\/3\/2026\/05\/ANST.v06.i1-2.p6.pdf\" target=\"_blank\" rel=\"noopener\"><em>Journal Advances of Nutrition Science and Technology<\/em>, 6(1-2), 35-45<\/a>. https:\/\/doi.org\/10.15228\/ANST.2026.v06.i01-2.p06<\/p><p><strong>Chicago\/Turabian Style<\/strong><br \/>S Usmani, F Caldwell, A Silva, M Assaad, N Sandoval, J Guardado, <em>Genetic Regulation of Vitamin C Transport: The Role of SLC23A1 in Nutrient Metabolism, Antioxidant Defense, and Human Health (2026)<\/em> <a href=\"https:\/\/chempublishers.com\/advances-of-nutrition-science-and-technology\/wp-content\/uploads\/sites\/3\/2026\/05\/ANST.v06.i1-2.p6.pdf\" target=\"_blank\" rel=\"noopener\"><em>Journal Advances of Nutrition Science and Technology<\/em>, 6(1-2), 35-45<\/a>. https:\/\/doi.org\/10.15228\/ANST.2026.v06.i01-2.p06<\/p><\/div><\/div><div class=\"item copyright\"><a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\"><img decoding=\"async\" src=\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\" alt=\"Creative Commons License\" \/><\/a><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-80b6472 e-con-full e-flex e-con e-child\" data-id=\"80b6472\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Review Article | Open AccessVolume 6 | Issue 01-2\u00a0 | Paper 06 |\u00a0 https:\/\/doi.org\/10.15228\/ANST.2026.v06.i01-2.p06 Genetic Regulation of Vitamin C Transport: The Role of SLC23A1 in Nutrient Metabolism, Antioxidant Defense, and Human Health Sarah UsmaniDepartment of Biological Sciences, California State University, Long Beach, 1250 Bellflower Blvd, MS 9502, Long Beach, CA 90840-9502, USA Fiona CaldwellDepartment of [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[34,35],"tags":[],"class_list":["post-4106","post","type-post","status-publish","format-standard","hentry","category-34","category-issue-1-2-2026"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Genetic Regulation of Vitamin C Transport: The Role of SLC23A1 in Nutrient Metabolism, Antioxidant Defense, and Human Health - The Journal Advances of Nutrition Science and Technology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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