{"id":247,"date":"2021-03-10T16:44:00","date_gmt":"2021-03-10T16:44:00","guid":{"rendered":"https:\/\/chempublishers.com\/anst\/?p=247"},"modified":"2025-11-03T13:13:23","modified_gmt":"2025-11-03T13:13:23","slug":"anst-0121","status":"publish","type":"post","link":"https:\/\/chempublishers.com\/advances-of-nutrition-science-and-technology\/2021\/03\/10\/anst-0121\/","title":{"rendered":"The Antibacterial and Antifungal Activities of Gatifloxacin and Its Metal Complexes"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"247\" class=\"elementor elementor-247\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fc7a96d e-flex e-con-boxed e-con e-parent\" data-id=\"fc7a96d\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-22df9d9 e-con-full e-flex e-con e-child\" data-id=\"22df9d9\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-91b26db elementor-widget elementor-widget-text-editor\" data-id=\"91b26db\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<table border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\"><tbody><tr><td><div><strong>Research Article | Open Access<\/strong><\/div><div class=\"item doi\"><span class=\"value\">Volume 1 | Issue 1\u00a0 | Paper 01 |\u00a0 <a href=\"https:\/\/chempublishers.com\/advances-of-nutrition-science-and-technology\/wp-content\/uploads\/sites\/3\/2024\/11\/ANST.2021.v01.i01.p01.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.15228\/ANST.2021.v01.i01.p01<\/a><\/span><\/div><\/td><\/tr><\/tbody><\/table><article class=\"obj_article_details\"><h1 class=\"page_title\">The Antibacterial and Antifungal Activities of Gatifloxacin and Its Metal Complexes<\/h1><div class=\"row\"><div class=\"main_entry\"><p><span class=\"name\">Muhammad Inam-Ul-Haq<\/span><\/p><p>Department of Chemistry, University of Karachi, Karachi, Pakistan<\/p><p><span class=\"name\">Tehseen Ahmed<\/span><\/p><p>Department of Chemistry, University of Karachi, Karachi, Pakistan<\/p><p><span class=\"name\">Fatima Ahmed<\/span><\/p><p>Department of Chemistry, University of Karachi, Karachi, Pakistan<\/p><table border=\"0\" width=\"93%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\"><tbody><tr><td align=\"center\" valign=\"top\"><strong>Received<\/strong><br \/>17 Aug, 2020<\/td><td align=\"center\" valign=\"top\"><strong>Accepted<\/strong><br \/>21 Nov, 2020<\/td><td align=\"center\" valign=\"top\"><strong>Published<\/strong><br \/>13 May, 2021<\/td><\/tr><\/tbody><\/table><div class=\"item abstract\"><p align=\"justify\">ABSTRACT:<\/p><p class=\"ql-align-justify\">The present article reports the biological activity of gatifloxacin separately and simultaneously as a ligand and in form of the metal complex\u00a0<em>in vitro<\/em>. Gatifloxacin is a member of the fluoroquinolone group and members of this group form metal complexes due to their high tendency to bind with metal ions. The metal complexes of the gatifloxacin synthesized with several metals like Mg(II), Al(III), Ca(II), Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) in a ratio of 1:2 molar ratios of metal and ligand (M: L). It was observed that the fluorine group at position 6 and the piperazine group at position 7 greatly enhanced the spectrum of activity. Antibacterial and antifungal activities of gatifloxacin and its metal complexes were determined by the agar diffusion method. The biological activity (antibacterial and antifungal) was tested against\u00a0<em>Escherichia coli<\/em>,\u00a0<em>Staphylococcus aureus<\/em>,\u00a0<em>Salmonella typhi<\/em>,\u00a0<em>Pseudomonas aeruginosa<\/em>,\u00a0<em>Campylobacter jejuni<\/em>,\u00a0<em>Neisseria gonorrhoeae<\/em>,\u00a0<em>Corynebacterium diphtherire<\/em>,\u00a0<em>Clostridium perfringens<\/em>,\u00a0<em>Pasteurella multocida<\/em>, and\u00a0<em>fungus Aspergillus niger<\/em>\u00a0and Fusarium oxysporum. It was concluded that the as-prepared gatifloxacin metal complexes with divalent and trivalent metal ions showed enhanced antibacterial activities while no antifungal activities in comparison to gatifloxacin were observed.<\/p><\/div><div class=\"item abstract\"><div><h3 class=\"label\">How to Cite this paper?<\/h3><div class=\"csl-entry\"><p><strong>APA-7 Style<\/strong><br \/>Inam-Ul-Haq, M., Ahmed, T., Ahmed, F. (2021). The Antibacterial and Antifungal Activities of Gatifloxacin and Its Metal Complexes.\u00a0<a href=\"https:\/\/doi.org\/0.15228\/ANST.2021.v01.i01.p01\" target=\"_blank\" rel=\"noopener\"><em>Journal Advances of Nutrition Science and Technology<\/em>, 1(1), 1-10<\/a>. https:\/\/doi.org\/0.15228\/ANST.2021.v01.i01.p01<\/p><p><strong>ACS Style<\/strong><br \/>Inam-Ul-Haq, M.; Ahmed, T.; Ahmed, F. The Antibacterial and Antifungal Activities of Gatifloxacin and Its Metal Complexes.\u00a0<a href=\"https:\/\/doi.org\/0.15228\/ANST.2021.v01.i01.p01\" target=\"_blank\" rel=\"noopener\"><em>J. Adv. Nutri. Sci. Tech.<\/em>\u00a02021, 1, 1-10<\/a>. https:\/\/doi.org\/0.15228\/ANST.2021.v01.i01.p01<\/p><p><strong>AMA Style<\/strong><br \/>Inam-Ul-Haq M, Ahmed T, Ahmed F. The Antibacterial and Antifungal Activities of Gatifloxacin and Its Metal Complexes.\u00a0<a href=\"https:\/\/doi.org\/0.15228\/ANST.2021.v01.i01.p01\" target=\"_blank\" rel=\"noopener\"><em>Journal Advances of Nutrition Science and Technology<\/em>. 2021; 1(1): 1-10<\/a>. https:\/\/doi.org\/0.15228\/ANST.2021.v01.i01.p01<\/p><p><strong>Chicago\/Turabian Style<\/strong><br \/>Inam-Ul-Haq, Muhammad, Tehseen Ahmed, and Fatima Ahmed. 2021. &#8220;The Antibacterial and Antifungal Activities of Gatifloxacin and Its Metal Complexes&#8221;\u00a0<a href=\"https:\/\/doi.org\/0.15228\/ANST.2021.v01.i01.p01\" target=\"_blank\" rel=\"noopener\"><em>Journal Advances of Nutrition Science and Technology<\/em>\u00a01, no. 1: 1-10<\/a>. https:\/\/doi.org\/0.15228\/ANST.2021.v01.i01.p01<\/p><\/div><\/div><\/div><div class=\"item copyright\"><p><a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\"><img decoding=\"async\" src=\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\" alt=\"Creative Commons License\" \/><\/a><\/p><p>This work is licensed under a\u00a0<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">Creative Commons Attribution 4.0 International License<\/a>.<\/p><\/div><\/div><\/div><\/article>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8ad4a0a e-con-full e-flex e-con e-child\" data-id=\"8ad4a0a\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Research Article | Open AccessVolume 1 | Issue 1\u00a0 | Paper 01 |\u00a0 https:\/\/doi.org\/10.15228\/ANST.2021.v01.i01.p01 The Antibacterial and Antifungal Activities of Gatifloxacin and Its Metal Complexes Muhammad Inam-Ul-Haq Department of Chemistry, University of Karachi, Karachi, Pakistan Tehseen Ahmed Department of Chemistry, University of Karachi, Karachi, Pakistan Fatima Ahmed Department of Chemistry, University of Karachi, Karachi, Pakistan [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[22,23],"tags":[],"class_list":["post-247","post","type-post","status-publish","format-standard","hentry","category-22","category-issue-01-2021"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The Antibacterial and Antifungal Activities of Gatifloxacin and Its Metal Complexes - The Journal Advances of Nutrition Science and Technology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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