{"id":163,"date":"2023-12-15T13:34:00","date_gmt":"2023-12-15T13:34:00","guid":{"rendered":"https:\/\/chempublishers.com\/anst\/?p=163"},"modified":"2025-02-13T21:14:37","modified_gmt":"2025-02-13T21:14:37","slug":"anst-0923","status":"publish","type":"post","link":"https:\/\/chempublishers.com\/advances-of-nutrition-science-and-technology\/2023\/12\/15\/anst-0923\/","title":{"rendered":"Assessment of the Antidiabetic Properties of Essential Oil from Cannabis sativa"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"163\" class=\"elementor elementor-163\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2d6319e e-flex e-con-boxed e-con e-parent\" data-id=\"2d6319e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-e780285 e-con-full e-flex e-con e-child\" data-id=\"e780285\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8714d29 elementor-widget elementor-widget-text-editor\" data-id=\"8714d29\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div id=\"pkp_content_main\" class=\"pkp_structure_main\" role=\"main\"><div class=\"page page_article\"><table border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\"><tbody><tr><td><div><strong>Research Article | Open Access<\/strong><\/div><div class=\"item doi\"><span class=\"value\">Volume 3 | Issue 3-4\u00a0 | Paper 09 |\u00a0 <a href=\"https:\/\/chempublishers.com\/advances-of-nutrition-science-and-technology\/wp-content\/uploads\/sites\/3\/2024\/11\/ANST.2023.v03.i03-4.p09.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.15228\/ANST. 2023.v03.i03-4.p09<\/a><\/span><\/div><\/td><\/tr><\/tbody><\/table><article class=\"obj_article_details\"><h1 class=\"page_title\">Assessment of the Antidiabetic Properties of Essential Oil from Cannabis sativa<\/h1><div class=\"row\"><div class=\"main_entry\"><p><span class=\"name\">Saima Naz<\/span><\/p><p>Department of Chemistry, University of Education Lahore, Faisalabad campus 37300 Pakistan<\/p><p><span class=\"name\">Ali Raza Kashif<\/span><\/p><p>Department of Chemistry, University of Education Lahore, Faisalabad campus 37300 Pakistan<\/p><p><span class=\"name\">Abdul Tawab<\/span><\/p><p>Department of Chemistry, University of Education Lahore, Faisalabad campus 37300 Pakistan<\/p><p><span class=\"name\">Muhammad Zaid Rasool<\/span><\/p><p>Department of Chemistry, University of Education Lahore, Faisalabad campus 37300 Pakistan<\/p><p><span class=\"name\">Abdul Rauf<\/span><\/p><p>Department of Chemistry, University of Education Lahore, Faisalabad campus 37300 Pakistan<\/p><p><span class=\"name\">Sabir Hussain<\/span><\/p><p>Department of Chemistry, University of Education Lahore, Faisalabad campus 37300 Pakistan<\/p><p><span class=\"name\">Umar Khan<\/span><\/p><p>Department of Chemistry, University of Education Lahore, Faisalabad campus 37300 Pakistan<\/p><table border=\"0\" width=\"93%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\"><tbody><tr><td align=\"center\" valign=\"top\"><strong>Received<\/strong><br \/>28 Sep, 2023<\/td><td align=\"center\" valign=\"top\"><strong>Accepted<\/strong><br \/>26 Dec, 2023<\/td><td align=\"center\" valign=\"top\"><strong>Published<\/strong><br \/>31 Dec, 2023<\/td><\/tr><\/tbody><\/table><div class=\"item abstract\"><p align=\"justify\">ABSTRACT:<\/p><p class=\"ql-align-justify\">This study used the hydrodistillation method to extract essential oil from\u00a0<em>Cannabis sativa<\/em>\u00a0(<em>C.sativa<\/em>) leaves, while its chemical composition was examined through gas chromatography-mass spectrometry. Experiments were conducted on alloxan-induced hyperglycemic rabbits (albino), with metformin as the reference medication for comparative analysis to evaluate its potential in managing diabetes. Chemical analysis showed that\u00a0the principal components of\u00a0<em>C.sativa<\/em>\u00a0essential oil were\u00a0<em>caryophyllene<\/em>\u00a0(46.63%),\u00a0<em>d-limonene\u00a0<\/em>(7.123%) and\u00a0<em>cis-\u03b2-farnescene<\/em>\u00a0(9.115%),\u00a0<em>humulene<\/em>\u00a0(13.153%) and\u00a0<em>trans-\u03b1-bergamotene<\/em>\u00a0(6.592%). The minor components (\u02c25%) include\u00a0<em>\u03b1-pinene<\/em>\u00a0(3.720%),\u00a0<em>\u03b2-myrcene<\/em>\u00a0(1.910%),\u00a0<em>cineole<\/em>\u00a0(2.340%),\u00a0<em>valencene<\/em>\u00a0(1.614%),\u00a0<em>\u03b2-bisabolene<\/em>\u00a0(1.897%) and unidentified components (4.201-4.452%) were respectively.\u00a0Intraperitoneal administration of\u00a0<em>C. sativa<\/em>\u00a0oil (0.7, 0.9 and 1.2\u00b5l\/kg b.wt.) to hyperglycemia for 14 days resulted in a noteworthy decrease in both hepatic and fasting blood glucose levels. Meanwhile, there was a marked increase in the hepatic concentration of glycogen. The oil administration exhibited a reduced yet favourable anti-hyperglycemic potential compared to the reference antidiabetic drug. The study&#8217;s findings indicate that the essential oil derived from \u00a0<em>C. sativa<\/em>\u00a0leaves cultivated in Pakistan is characterized as a Beta Caryophyllene chemotype. Remarkably, the oil demonstrated significant efficacy in lowering glucose levels and showed promise in mitigating hyperglycemia-induced dyslipidemic complications in rabbits induced with alloxan.<\/p><\/div><div class=\"item abstract\"><div><h3 class=\"label\">How to Cite this paper?<\/h3><div class=\"csl-entry\"><p><strong>APA-7 Style<\/strong><br \/>Naz, S., Kashif, A.R., Tawab, A., Rasool, M.Z., Rauf, A., Hussain, S., Khan, U. (2023). Assessment of the Antidiabetic Properties of Essential Oil from Cannabis sativa.\u00a0<a href=\"https:\/\/doi.org\/10.15228\/ANST.%202023.v03.i03-4.p09\" target=\"_blank\" rel=\"noopener\"><em>Journal Advances of Nutrition Science and Technology<\/em>, 3(3-4), 78-86<\/a>. https:\/\/doi.org\/10.15228\/ANST. 2023.v03.i03-4.p09<\/p><p><strong>ACS Style<\/strong><br \/>Naz, S.; Kashif, A.R.; Tawab, A.; Rasool, M.Z.; Rauf, A.; Hussain, S.; Khan, U. Assessment of the Antidiabetic Properties of Essential Oil from Cannabis sativa.\u00a0<a href=\"https:\/\/doi.org\/10.15228\/ANST.%202023.v03.i03-4.p09\" target=\"_blank\" rel=\"noopener\"><em>J. Adv. Nutri. Sci. Tech.<\/em>\u00a02023, 3, 78-86<\/a>. https:\/\/doi.org\/10.15228\/ANST. 2023.v03.i03-4.p09<\/p><p><strong>AMA Style<\/strong><br \/>Naz S, Kashif AR, Tawab A, Rasool MZ, Rauf A, Hussain S, Khan U. Assessment of the Antidiabetic Properties of Essential Oil from Cannabis sativa.\u00a0<a href=\"https:\/\/doi.org\/10.15228\/ANST.%202023.v03.i03-4.p09\" target=\"_blank\" rel=\"noopener\"><em>Journal Advances of Nutrition Science and Technology<\/em>. 2023; 3(3-4): 78-86<\/a>. https:\/\/doi.org\/10.15228\/ANST. 2023.v03.i03-4.p09<\/p><p><strong>Chicago\/Turabian Style<\/strong><br \/>Naz, Saima, Ali Raza Kashif, Abdul Tawab, Muhammad Zaid Rasool, Abdul Rauf, Sabir Hussain, and Umar Khan. 2023. &#8220;Assessment of the Antidiabetic Properties of Essential Oil from Cannabis sativa&#8221;\u00a0<a href=\"https:\/\/chempublishers.com\/advances-of-nutrition-science-and-technology\/wp-content\/uploads\/sites\/3\/2024\/11\/ANST.2023.v03.i03-4.p09.pdf\" target=\"_blank\" rel=\"noopener\"><em>Journal Advances of Nutrition Science and Technology<\/em>\u00a03, no. 3-4: 78-86<\/a>. https:\/\/doi.org\/10.15228\/ANST. 2023.v03.i03-4.p09<\/p><\/div><\/div><\/div><div class=\"item copyright\"><p><a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\"><img decoding=\"async\" src=\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\" alt=\"Creative Commons License\" \/><\/a><\/p><p>This work is licensed under a\u00a0<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">Creative Commons Attribution 4.0 International License<\/a>.<\/p><\/div><\/div><\/div><\/article><\/div><\/div><div class=\"pkp_structure_sidebar left\" role=\"complementary\" aria-label=\"Sidebar\">\u00a0<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cabeac0 e-con-full e-flex e-con e-child\" data-id=\"cabeac0\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Research Article | Open AccessVolume 3 | Issue 3-4\u00a0 | Paper 09 |\u00a0 https:\/\/doi.org\/10.15228\/ANST. 2023.v03.i03-4.p09 Assessment of the Antidiabetic Properties of Essential Oil from Cannabis sativa Saima Naz Department of Chemistry, University of Education Lahore, Faisalabad campus 37300 Pakistan Ali Raza Kashif Department of Chemistry, University of Education Lahore, Faisalabad campus 37300 Pakistan Abdul Tawab [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[15,17],"tags":[],"class_list":["post-163","post","type-post","status-publish","format-standard","hentry","category-15","category-issue-3-4-2023"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Assessment of the Antidiabetic Properties of Essential Oil from Cannabis sativa - The Journal Advances of Nutrition Science and Technology<\/title>\n<meta name=\"robots\" content=\"index, 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