{"id":3045,"date":"2023-12-01T21:06:00","date_gmt":"2023-12-01T21:06:00","guid":{"rendered":"https:\/\/chempublishers.com\/pjc\/?p=3045"},"modified":"2025-06-13T11:54:48","modified_gmt":"2025-06-13T11:54:48","slug":"pjc-0723","status":"publish","type":"post","link":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2023\/12\/01\/pjc-0723\/","title":{"rendered":"Chemical Modulation of RNA Epigenetic Modifications"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"3045\" class=\"elementor elementor-3045\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-88e3dfd e-flex e-con-boxed e-con e-parent\" data-id=\"88e3dfd\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-e7971df e-con-full e-flex e-con e-child\" data-id=\"e7971df\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b08f157 elementor-widget elementor-widget-text-editor\" data-id=\"b08f157\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<table border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\">\n<tbody>\n<tr>\n<td>\n<div><strong>Review Article | Open Access<\/strong><\/div>\n<div class=\"item doi\"><span class=\"value\">Volume 13 | Issue 3-4 |&nbsp;<a href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2024\/12\/PJC.v13.i03-4.p1.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.15228\/2023.v13.i03-4.p01<\/a><\/span><\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<article class=\"obj_article_details\">\n<h4>Chemical Modulation of RNA Epigenetic Modifications<\/h4>\n<div class=\"row\">\n<div class=\"main_entry\">\n<p><span class=\"name\">L. Cheng<\/span><\/p>\n<p>Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, CAS Research\/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China, and University of Chinese Academy of Sciences, Beijing 100049, China<\/p>\n<p><\/p>\n<table border=\"0\" width=\"93%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\">\n<tbody>\n<tr>\n<td align=\"center\" valign=\"top\"><strong>Received<\/strong><br>04 Apr, 2023<\/td>\n<td align=\"center\" valign=\"top\"><strong>Accepted<\/strong><br>11 Jun, 2023<\/td>\n<td align=\"center\" valign=\"top\"><strong>Published<\/strong><br>12 Jul, 2023<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div class=\"item abstract\">\n<p class=\"ql-align-justify\">Given the increasing evidence demonstrating the notable functions of RNA modifications, the precise regulation of a particular epigenetic mark is high desirable. Current genetic techniques like over-expression or knockout of corresponding genes\/proteins, as well as the development of molecular inhibitors\/antagonists of these enzymes facilitated a prompt epigenetic associated phenotype observation. However, these approaches heavily relied on the characterization of RNA modifying enzymes.&nbsp;<em>In vitro<\/em>&nbsp;or&nbsp;<em>in vivo<\/em>&nbsp;alteration of RNA epigenetics, especially for those modifications whose pathways have not been identified, through direct chemical interventions with small organic molecules would fulfill this gap and is thus highly desirable. Considering the fact that those enzymatic modifications and de-modifications are chemical reactions occurred in the homeostasis constraints of a living system, we believe it would be possible for developing the corresponding their biomimetic counterparts. In this&nbsp;<em>Review<\/em>, we will present our recent advances regarding the direct chemical interventions towards several biologically important RNA modifications and their applications in live cells or growing plants. We have demonstrated that the demethylation process of N<sup>6<\/sup>-methyladenosine m<sup>6<\/sup>A in live cells could be accomplished through Flavin mononucleotide prompted biocompatible photo-oxidation. This is the first example of small organic molecules modulating&nbsp;<em>in vitro<\/em>&nbsp;RNA epigenetic modifications. We also presented a straightforward transformation for the generation of 5-formylcytidine f<sup>5<\/sup>C from 5-methylcytidine m<sup>5<\/sup>C using anthraquinone-2-sulfonate without oxidizing other biomacromolecules or redundancy production of 5-hydroxymethylcytidine hm<sup>5<\/sup>C. Most recently, we reported that oxoammonium cations might be applied as artificial deprenylases for the highly sensitive and selective demodification of N<sup>6<\/sup>-prenyladenosine i<sup>6<\/sup>A in oligonucleotides, cells and even live plants. One of the most striking features of these \u201c<em>artificial enzymes<\/em>\u201d is their low cytotoxic activity on cells and extraordinary capability in regulating designated modifications without over-expression or inhibiting corresponding enzymes or disturbing other epigenetics, nucleic acids, or proteins. The objective of this Review is to present the research findings regarding the design, synthesis and evaluation of highly efficient chemical reagents and biocompatible transformations toward selected RNA epigenetics that have enabled chemists\u2019 ability to not just controlling&nbsp;<em>in vitro<\/em>\/<em>in vivo<\/em>&nbsp;RNA modifications, but also introducing artificial variants onto natural RNAs, without disturbing any related enzymes. Such double direction regulating may considerably help in the function interpretation\/installation\/modulation of versatile modifications pertaining to RNAs. The ability of those chemical motifs will undoubtedly illuminate undisclosed functions and regulatory mechanisms affiliated to the vast majority of discovered modifications and has the potential to enable treatments for related human diseases.&nbsp;<\/p>\n<\/div>\n<div class=\"item abstract\">\n<div>\n<h3 class=\"label\">How to Cite this paper?<\/h3>\n<div class=\"csl-entry\">\n<p><strong>APA-7 Style<\/strong><br>Cheng, L. (2023). Chemical Modulation of RNA Epigenetic Modifications.&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2023.v13.i03-4.p01\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>, 13(3-4), 57-66<\/a>. https:\/\/doi.org\/10.15228\/2023.v13.i03-4.p01<\/p>\n<p><strong>ACS Style<\/strong><br>Cheng, L. Chemical Modulation of RNA Epigenetic Modifications.&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2023.v13.i03-4.p01\" target=\"_blank\" rel=\"noopener\"><em>Pak. J. Chem.<\/em>&nbsp;2023, 13, 57-66<\/a>. https:\/\/doi.org\/10.15228\/2023.v13.i03-4.p01<\/p>\n<p><strong>AMA Style<\/strong><br>Cheng L. Chemical Modulation of RNA Epigenetic Modifications.&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2023.v13.i03-4.p01\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>. 2023; 13(3-4): 57-66<\/a>. https:\/\/doi.org\/10.15228\/2023.v13.i03-4.p01<\/p>\n<p><strong>Chicago\/Turabian Style<\/strong><br>Cheng, L.. 2023. &#8220;Chemical Modulation of RNA Epigenetic Modifications&#8221;&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2023.v13.i03-4.p01\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>&nbsp;13, no. 3-4: 57-66<\/a>. https:\/\/doi.org\/10.15228\/2023.v13.i03-4.p01<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"item copyright\">\n<p><a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\"><img decoding=\"async\" src=\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\" alt=\"Creative Commons License\"><\/a><\/p>\n<p>This work is licensed under a&nbsp;<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">Creative Commons Attribution 4.0 International License<\/a>.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/article>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f6a6a53 e-con-full e-flex e-con e-child\" data-id=\"f6a6a53\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Review Article | Open Access Volume 13 | Issue 3-4 |&nbsp;https:\/\/doi.org\/10.15228\/2023.v13.i03-4.p01 Chemical Modulation of RNA Epigenetic Modifications L. Cheng Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, CAS Research\/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China, and University of [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-3045","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Chemical Modulation of RNA Epigenetic Modifications - Pakistan Journal of Chemistry<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2023\/12\/01\/pjc-0723\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Chemical Modulation of RNA Epigenetic Modifications - Pakistan Journal of Chemistry\" \/>\n<meta property=\"og:description\" content=\"Review Article | Open Access Volume 13 | Issue 3-4 |&nbsp;https:\/\/doi.org\/10.15228\/2023.v13.i03-4.p01 Chemical Modulation of RNA Epigenetic Modifications L. 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