{"id":3000,"date":"2022-12-20T18:52:00","date_gmt":"2022-12-20T18:52:00","guid":{"rendered":"https:\/\/chempublishers.com\/pjc\/?p=3000"},"modified":"2025-01-24T12:58:09","modified_gmt":"2025-01-24T12:58:09","slug":"pjc-1022","status":"publish","type":"post","link":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/","title":{"rendered":"Albumin Binding and Anticancer Studies of trimethyl-, and triphenylstannyl (4R)-4-((3R,5R,10S,12S,13R,17R)-3,12-dihydroxy- 10,13-dimethylhexadecahydro-1Hcyclopenta[a]phenanthren-17-yl)pentanoate)"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"3000\" class=\"elementor elementor-3000\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0a83a19 e-flex e-con-boxed e-con e-parent\" data-id=\"0a83a19\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-c21988a e-con-full e-flex e-con e-child\" data-id=\"c21988a\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-263f735 elementor-widget elementor-widget-text-editor\" data-id=\"263f735\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<table border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\"><tbody><tr><td><div><strong>Research Article | Open Access<\/strong><\/div><div class=\"item doi\"><span class=\"value\">Volume 12 | Issue 3-4 |\u00a0<a href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2024\/12\/PJC.v12.i03-4.p10.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.15228\/2022.v12.i03-4.p10<\/a><\/span><\/div><\/td><\/tr><\/tbody><\/table><article class=\"obj_article_details\"><h1 class=\"page_title\">Albumin Binding and Anticancer Studies of trimethyl-, and triphenylstannyl (4R)-4-((3R,5R,10S,12S,13R,17R)-3,12-dihydroxy- 10,13-dimethylhexadecahydro-1Hcyclopenta[a]phenanthren-17-yl)pentanoate)<\/h1><div class=\"row\"><div class=\"main_entry\"><p><span class=\"name\">F. Shaheen<\/span><\/p><p>Department of Chemistry, Faculty of Science, Allama Iqbal Open University H-8\/4 Campus Islamabad 44310, Pakistan<\/p><p><span class=\"name\">S. Ali<\/span><\/p><p>Department of Chemistry, Faculty of Science, Quaid-i-Azam University, Islamabad 45320, Pakistan<\/p><p><span class=\"name\">T. Amir<\/span><\/p><p>Department of Chemistry, Faculty of Basic Science, University of Wah, Quaid Avenue Wah, 47040, Pakistan<\/p><p><span class=\"name\">G. Wagnieres<\/span><\/p><p>Ecole polytechnique f\u00e9d\u00e9rale de Lausanne Institut des sciences et ing\u00e9nierie chimiques, EPFL SB ISIC LCOM CH H5 595 (B\u00e2timent CH) Station 6 CH-1015 Lausanne Switzerland<\/p><p><span class=\"name\">V. Huntosova<\/span><\/p><p>Ecole polytechnique f\u00e9d\u00e9rale de Lausanne Institut des sciences et ing\u00e9nierie chimiques, EPFL SB ISIC LCOM CH H5 595 (B\u00e2timent CH) Station 6 CH-1015 Lausanne Switzerland<\/p><p>\u00a0<\/p><table border=\"0\" width=\"93%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\"><tbody><tr><td align=\"center\" valign=\"top\"><strong>Received<\/strong><br \/>12 Aug, 2022<\/td><td align=\"center\" valign=\"top\"><strong>Accepted<\/strong><br \/>21 Nov, 2022<\/td><td align=\"center\" valign=\"top\"><strong>Published<\/strong><br \/>11 Jan, 2023<\/td><\/tr><\/tbody><\/table><p>\u00a0<\/p><div class=\"item abstract\"><p class=\"ql-align-justify\">Trimethyl- (1) and triphenyl tin (2) derivatives of sodium (R)-4-{(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl} pentanoate (sodium deoxycholate) were synthesized by refluxing sodium deoxycholate with the corresponding triorganotin(IV) chlorides in equimolar ratio. The two compounds were characterized by elemental analysis, infrared spectroscopy,\u00a0<sup>1<\/sup>H,\u00a0<sup>13<\/sup>C,\u00a0<sup>119<\/sup>Sn NMR spectroscopy. Base on FT-IR spectra, \u0394\u03bd values anticipated bridging or chelating behavior of the ligand. Both the compounds gave a trigonal bipyramidal geometry in the solid state and tetrahedral geometry in solution. The interaction of (1) and (2) with bovine and human serum albumin was investigated at two different temperatures (298 and 310K) utilizing fluorescence quenching experiments. Fluorescence quenching constants were determined from the Stern-Volmer equation. Both the compounds bind with Bovine serum albumin (BSA) and Human serum albumin (HAS) through a dynamic quenching pathway. Compound 1 binds with BSA and HSA at two temperatures with an association constant of 3.9 x 10<sup>4<\/sup>\u00a0and 8.0 x 10<sup>4<\/sup>\u00a0at 298K and 9.9 x 10<sup>4<\/sup>\u00a0and 1.02 x 10<sup>4<\/sup>\u00a0at 310K, respectively. Similarly, compound 2 binds with BSA and HSA with quenching constants of 3.9 x 10<sup>4<\/sup>\u00a0and 1.8 x 10<sup>4<\/sup>\u00a0at 298K and 1.4 x 10<sup>4<\/sup>\u00a0and 4.5 x 10<sup>4<\/sup>, respectively. The synchronous fluorescence spectrum of compounds suggested that the tryptophan residues contribute significantly to intrinsic fluorescence quenching.<\/p><\/div><div class=\"item abstract\"><div><h3 class=\"label\">How to Cite this paper?<\/h3><div class=\"csl-entry\"><p><strong>APA-7 Style<\/strong><br \/>Shaheen, F., Ali, S., Amir, T., Wagnieres, G., Huntosova, V. (2022). Albumin Binding and Anticancer Studies of trimethyl-, and triphenylstannyl (4R)-4-((3R,5R,10S,12S,13R,17R)-3,12-dihydroxy- 10,13-dimethylhexadecahydro-1Hcyclopenta[a]phenanthren-17-yl)pentanoate).\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2022.v12.i03-4.p10\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>, 12(3-4), 76-85<\/a>. https:\/\/doi.org\/10.15228\/2022.v12.i03-4.p10<\/p><p><strong>ACS Style<\/strong><br \/>Shaheen, F.; Ali, S.; Amir, T.; Wagnieres, G.; Huntosova, V. Albumin Binding and Anticancer Studies of trimethyl-, and triphenylstannyl (4R)-4-((3R,5R,10S,12S,13R,17R)-3,12-dihydroxy- 10,13-dimethylhexadecahydro-1Hcyclopenta[a]phenanthren-17-yl)pentanoate).\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2022.v12.i03-4.p10\" target=\"_blank\" rel=\"noopener\"><em>Pak. J. Chem.<\/em>\u00a02022, 12, 76-85<\/a>. https:\/\/doi.org\/10.15228\/2022.v12.i03-4.p10<\/p><p><strong>AMA Style<\/strong><br \/>Shaheen F, Ali S, Amir T, Wagnieres G, Huntosova V. Albumin Binding and Anticancer Studies of trimethyl-, and triphenylstannyl (4R)-4-((3R,5R,10S,12S,13R,17R)-3,12-dihydroxy- 10,13-dimethylhexadecahydro-1Hcyclopenta[a]phenanthren-17-yl)pentanoate).\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2022.v12.i03-4.p10\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>. 2022; 12(3-4): 76-85<\/a>. https:\/\/doi.org\/10.15228\/2022.v12.i03-4.p10<\/p><p><strong>Chicago\/Turabian Style<\/strong><br \/>Shaheen, F., S. Ali, T. Amir, G. Wagnieres, and V. Huntosova. 2022. &#8220;Albumin Binding and Anticancer Studies of trimethyl-, and triphenylstannyl (4R)-4-((3R,5R,10S,12S,13R,17R)-3,12-dihydroxy- 10,13-dimethylhexadecahydro-1Hcyclopenta[a]phenanthren-17-yl)pentanoate)&#8221;\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2022.v12.i03-4.p10\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>\u00a012, no. 3-4: 76-85<\/a>. https:\/\/doi.org\/10.15228\/2022.v12.i03-4.p10<\/p><\/div><\/div><\/div><div class=\"item copyright\"><p><a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\"><img decoding=\"async\" src=\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\" alt=\"Creative Commons License\" \/><\/a><\/p><p>This work is licensed under a\u00a0<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">Creative Commons Attribution 4.0 International License<\/a>.<\/p><\/div><\/div><\/div><\/article>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-aaba88c e-con-full e-flex e-con e-child\" data-id=\"aaba88c\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Research Article | Open AccessVolume 12 | Issue 3-4 |\u00a0https:\/\/doi.org\/10.15228\/2022.v12.i03-4.p10 Albumin Binding and Anticancer Studies of trimethyl-, and triphenylstannyl (4R)-4-((3R,5R,10S,12S,13R,17R)-3,12-dihydroxy- 10,13-dimethylhexadecahydro-1Hcyclopenta[a]phenanthren-17-yl)pentanoate) F. Shaheen Department of Chemistry, Faculty of Science, Allama Iqbal Open University H-8\/4 Campus Islamabad 44310, Pakistan S. Ali Department of Chemistry, Faculty of Science, Quaid-i-Azam University, Islamabad 45320, Pakistan T. Amir Department of [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-3000","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Albumin Binding and Anticancer Studies of trimethyl-, and triphenylstannyl (4R)-4-((3R,5R,10S,12S,13R,17R)-3,12-dihydroxy- 10,13-dimethylhexadecahydro-1Hcyclopenta[a]phenanthren-17-yl)pentanoate) - Pakistan Journal of Chemistry<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Albumin Binding and Anticancer Studies of trimethyl-, and triphenylstannyl (4R)-4-((3R,5R,10S,12S,13R,17R)-3,12-dihydroxy- 10,13-dimethylhexadecahydro-1Hcyclopenta[a]phenanthren-17-yl)pentanoate) - Pakistan Journal of Chemistry\" \/>\n<meta property=\"og:description\" content=\"Research Article | Open AccessVolume 12 | Issue 3-4 |\u00a0https:\/\/doi.org\/10.15228\/2022.v12.i03-4.p10 Albumin Binding and Anticancer Studies of trimethyl-, and triphenylstannyl (4R)-4-((3R,5R,10S,12S,13R,17R)-3,12-dihydroxy- 10,13-dimethylhexadecahydro-1Hcyclopenta[a]phenanthren-17-yl)pentanoate) F. Shaheen Department of Chemistry, Faculty of Science, Allama Iqbal Open University H-8\/4 Campus Islamabad 44310, Pakistan S. Ali Department of Chemistry, Faculty of Science, Quaid-i-Azam University, Islamabad 45320, Pakistan T. Amir Department of [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/\" \/>\n<meta property=\"og:site_name\" content=\"Pakistan Journal of Chemistry\" \/>\n<meta property=\"article:published_time\" content=\"2022-12-20T18:52:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-01-24T12:58:09+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#\/schema\/person\/5f5f92c274f1346d6f53fa7864e00a01\"},\"headline\":\"Albumin Binding and Anticancer Studies of trimethyl-, and triphenylstannyl (4R)-4-((3R,5R,10S,12S,13R,17R)-3,12-dihydroxy- 10,13-dimethylhexadecahydro-1Hcyclopenta[a]phenanthren-17-yl)pentanoate)\",\"datePublished\":\"2022-12-20T18:52:00+00:00\",\"dateModified\":\"2025-01-24T12:58:09+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/\"},\"wordCount\":597,\"publisher\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#organization\"},\"image\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/\",\"url\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/\",\"name\":\"Albumin Binding and Anticancer Studies of trimethyl-, and triphenylstannyl (4R)-4-((3R,5R,10S,12S,13R,17R)-3,12-dihydroxy- 10,13-dimethylhexadecahydro-1Hcyclopenta[a]phenanthren-17-yl)pentanoate) - Pakistan Journal of Chemistry\",\"isPartOf\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\",\"datePublished\":\"2022-12-20T18:52:00+00:00\",\"dateModified\":\"2025-01-24T12:58:09+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/#primaryimage\",\"url\":\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\",\"contentUrl\":\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Albumin Binding and Anticancer Studies of trimethyl-, and triphenylstannyl (4R)-4-((3R,5R,10S,12S,13R,17R)-3,12-dihydroxy- 10,13-dimethylhexadecahydro-1Hcyclopenta[a]phenanthren-17-yl)pentanoate)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#website\",\"url\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/\",\"name\":\"Pakistan Journal of Chemistry\",\"description\":\"Pakistan Journal of Chemistry is an international, double-blind,peer-reviewed, open-access Pakistan Based Journal published by Chem Publishers.\",\"publisher\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#organization\",\"name\":\"Pakistan Journal of Chemistry\",\"url\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2024\/12\/cropped-WhatsApp-Image-2024-12-11-at-23.54.08_6d6c4771-1.jpg\",\"contentUrl\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2024\/12\/cropped-WhatsApp-Image-2024-12-11-at-23.54.08_6d6c4771-1.jpg\",\"width\":1129,\"height\":1600,\"caption\":\"Pakistan Journal of Chemistry\"},\"image\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#\/schema\/person\/5f5f92c274f1346d6f53fa7864e00a01\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/ea649f84ccd0f114678afc2b56b41940?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/ea649f84ccd0f114678afc2b56b41940?s=96&d=mm&r=g\",\"caption\":\"admin\"},\"sameAs\":[\"https:\/\/chempublishers.com\"],\"url\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/author\/chempublisherspk\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Albumin Binding and Anticancer Studies of trimethyl-, and triphenylstannyl (4R)-4-((3R,5R,10S,12S,13R,17R)-3,12-dihydroxy- 10,13-dimethylhexadecahydro-1Hcyclopenta[a]phenanthren-17-yl)pentanoate) - Pakistan Journal of Chemistry","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/","og_locale":"en_US","og_type":"article","og_title":"Albumin Binding and Anticancer Studies of trimethyl-, and triphenylstannyl (4R)-4-((3R,5R,10S,12S,13R,17R)-3,12-dihydroxy- 10,13-dimethylhexadecahydro-1Hcyclopenta[a]phenanthren-17-yl)pentanoate) - Pakistan Journal of Chemistry","og_description":"Research Article | Open AccessVolume 12 | Issue 3-4 |\u00a0https:\/\/doi.org\/10.15228\/2022.v12.i03-4.p10 Albumin Binding and Anticancer Studies of trimethyl-, and triphenylstannyl (4R)-4-((3R,5R,10S,12S,13R,17R)-3,12-dihydroxy- 10,13-dimethylhexadecahydro-1Hcyclopenta[a]phenanthren-17-yl)pentanoate) F. Shaheen Department of Chemistry, Faculty of Science, Allama Iqbal Open University H-8\/4 Campus Islamabad 44310, Pakistan S. Ali Department of Chemistry, Faculty of Science, Quaid-i-Azam University, Islamabad 45320, Pakistan T. Amir Department of [&hellip;]","og_url":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/","og_site_name":"Pakistan Journal of Chemistry","article_published_time":"2022-12-20T18:52:00+00:00","article_modified_time":"2025-01-24T12:58:09+00:00","og_image":[{"url":"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png","type":"","width":"","height":""}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Written by":"admin","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/#article","isPartOf":{"@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/"},"author":{"name":"admin","@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#\/schema\/person\/5f5f92c274f1346d6f53fa7864e00a01"},"headline":"Albumin Binding and Anticancer Studies of trimethyl-, and triphenylstannyl (4R)-4-((3R,5R,10S,12S,13R,17R)-3,12-dihydroxy- 10,13-dimethylhexadecahydro-1Hcyclopenta[a]phenanthren-17-yl)pentanoate)","datePublished":"2022-12-20T18:52:00+00:00","dateModified":"2025-01-24T12:58:09+00:00","mainEntityOfPage":{"@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/"},"wordCount":597,"publisher":{"@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#organization"},"image":{"@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/#primaryimage"},"thumbnailUrl":"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/","url":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/","name":"Albumin Binding and Anticancer Studies of trimethyl-, and triphenylstannyl (4R)-4-((3R,5R,10S,12S,13R,17R)-3,12-dihydroxy- 10,13-dimethylhexadecahydro-1Hcyclopenta[a]phenanthren-17-yl)pentanoate) - Pakistan Journal of Chemistry","isPartOf":{"@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#website"},"primaryImageOfPage":{"@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/#primaryimage"},"image":{"@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/#primaryimage"},"thumbnailUrl":"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png","datePublished":"2022-12-20T18:52:00+00:00","dateModified":"2025-01-24T12:58:09+00:00","breadcrumb":{"@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/#primaryimage","url":"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png","contentUrl":"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png"},{"@type":"BreadcrumbList","@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2022\/12\/20\/pjc-1022\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/"},{"@type":"ListItem","position":2,"name":"Albumin Binding and Anticancer Studies of trimethyl-, and triphenylstannyl (4R)-4-((3R,5R,10S,12S,13R,17R)-3,12-dihydroxy- 10,13-dimethylhexadecahydro-1Hcyclopenta[a]phenanthren-17-yl)pentanoate)"}]},{"@type":"WebSite","@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#website","url":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/","name":"Pakistan Journal of Chemistry","description":"Pakistan Journal of Chemistry is an international, double-blind,peer-reviewed, open-access Pakistan Based Journal published by Chem Publishers.","publisher":{"@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#organization","name":"Pakistan Journal of Chemistry","url":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#\/schema\/logo\/image\/","url":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2024\/12\/cropped-WhatsApp-Image-2024-12-11-at-23.54.08_6d6c4771-1.jpg","contentUrl":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2024\/12\/cropped-WhatsApp-Image-2024-12-11-at-23.54.08_6d6c4771-1.jpg","width":1129,"height":1600,"caption":"Pakistan Journal of Chemistry"},"image":{"@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#\/schema\/person\/5f5f92c274f1346d6f53fa7864e00a01","name":"admin","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/ea649f84ccd0f114678afc2b56b41940?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/ea649f84ccd0f114678afc2b56b41940?s=96&d=mm&r=g","caption":"admin"},"sameAs":["https:\/\/chempublishers.com"],"url":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/author\/chempublisherspk\/"}]}},"_links":{"self":[{"href":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-json\/wp\/v2\/posts\/3000","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-json\/wp\/v2\/comments?post=3000"}],"version-history":[{"count":6,"href":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-json\/wp\/v2\/posts\/3000\/revisions"}],"predecessor-version":[{"id":5795,"href":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-json\/wp\/v2\/posts\/3000\/revisions\/5795"}],"wp:attachment":[{"href":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-json\/wp\/v2\/media?parent=3000"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-json\/wp\/v2\/categories?post=3000"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-json\/wp\/v2\/tags?post=3000"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}