{"id":2918,"date":"2020-08-31T16:57:00","date_gmt":"2020-08-31T16:57:00","guid":{"rendered":"https:\/\/chempublishers.com\/pjc\/?p=2918"},"modified":"2025-06-13T13:22:26","modified_gmt":"2025-06-13T13:22:26","slug":"pjc-0120","status":"publish","type":"post","link":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2020\/08\/31\/pjc-0120\/","title":{"rendered":"A Novel Rp-Hplc Method for Simultaneous Estimation of Dorzolamide and Timolol Maleate in Ophthalmic Products"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2918\" class=\"elementor elementor-2918\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9fc7eb7 e-flex e-con-boxed e-con e-parent\" data-id=\"9fc7eb7\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-bc3782c e-con-full e-flex e-con e-child\" data-id=\"bc3782c\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-254d654 elementor-widget elementor-widget-text-editor\" data-id=\"254d654\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<table border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\">\n<tbody>\n<tr>\n<td>\n<div><strong>Research Article | Open Access<\/strong><\/div>\n<div class=\"item doi\"><span class=\"value\">Volume 10 | Issue 1-4 |&nbsp;<a href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2024\/12\/PJC-v10.i01-04.p01.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.15228\/2020.v10.i01-4.p01<\/a><\/span><\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<article class=\"obj_article_details\">\n<h4>A Novel Rp-Hplc Method for Simultaneous Estimation of Dorzolamide and Timolol Maleate in Ophthalmic Products<\/h4>\n<div class=\"row\">\n<div class=\"main_entry\">\n<p><span class=\"name\">N. Sher<\/span><\/p>\n<p>Department of Chemistry, Faculty of Science, University of Karachi, Karachi, Pakistan 75270<\/p>\n<p><span class=\"name\">N. Shafi<\/span><\/p>\n<p>Department of Chemistry, Faculty of Science, University of Karachi, Karachi, Pakistan 75270<\/p>\n<p><span class=\"name\">H. Naseem<\/span><\/p>\n<p>Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ziauddin University Karachi, Pakistan<\/p>\n<p><span class=\"name\">M.A. Khan<\/span><\/p>\n<p>Saudi Pharmaceutical Industries, Industrial Area Police Station, Ayub Ibn Ishaq St, Sinaiya, Riyadh, Saudi Arabia,11383<\/p>\n<p><\/p>\n<table border=\"0\" width=\"93%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\">\n<tbody>\n<tr>\n<td align=\"center\" valign=\"top\"><strong>Received<\/strong><br>13 Jan, 2020<\/td>\n<td align=\"center\" valign=\"top\"><strong>Accepted<\/strong><br>22 Jun, 2020<\/td>\n<td align=\"center\" valign=\"top\"><strong>Published<\/strong><br>07 Jun, 2021<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div class=\"item abstract\">\n<p class=\"ql-align-justify\">This research introduces an RP-HPLC method to estimate dorzolamide and timolol maleate quantitatively in the simultaneous mode. The stationary phase has consisted of A phenomenix<sup>\u00ae<\/sup>&nbsp;C18 column which gave satisfactory separation of these drugs when subjected to analysis, where in the mobile phase is composed of Acetonitrile:Buffer (20:80,v\/v). The instrument was set up as such that the pump draws mobile phase at a flow rate of 1.0 mL\/min and monitored at 290nm wavelength. Linear relationship of concentration of drugs vs. peak area was ascertained to assess linearity parameters and a correlation coefficient of more than 0.9995 for all the drugs was achieved when studied in a range of 10 to 1000 ug\/mL. The newly developed method showed high accuracy and precision with a percent recovery of 98.85% &#8211; 101.23% and a percent relief standard deviation of 0.5 \u2013 1.7 %. The optimized method was validated according to the guideline laid down by ICH and was successfully applied to quantitate both the drugs in bulk, raw material, eye drops formulation and in physiological fluids.<\/p>\n<\/div>\n<div class=\"item abstract\">\n<div>\n<h3 class=\"label\">How to Cite this paper?<\/h3>\n<div class=\"csl-entry\">\n<p><strong>APA-7 Style<\/strong><br>Sher, N., Shafi, N., Naseem, H., Khan, M.A. (2020). A Novel Rp-Hplc Method for Simultaneous Estimation of Dorzolamide and Timolol Maleate in Ophthalmic Products.&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2020.v10.i01-4.p01\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>, 10(1-4), 1-6<\/a>. https:\/\/doi.org\/10.15228\/2020.v10.i01-4.p01<\/p>\n<p><strong>ACS Style<\/strong><br>Sher, N.; Shafi, N.; Naseem, H.; Khan, M.A. A Novel Rp-Hplc Method for Simultaneous Estimation of Dorzolamide and Timolol Maleate in Ophthalmic Products.&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2020.v10.i01-4.p01\" target=\"_blank\" rel=\"noopener\"><em>Pak. J. Chem.<\/em>&nbsp;2020, 10, 1-6<\/a>. https:\/\/doi.org\/10.15228\/2020.v10.i01-4.p01<\/p>\n<p><strong>AMA Style<\/strong><br>Sher N, Shafi N, Naseem H, Khan MA. A Novel Rp-Hplc Method for Simultaneous Estimation of Dorzolamide and Timolol Maleate in Ophthalmic Products.&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2020.v10.i01-4.p01\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>. 2020; 10(1-4): 1-6<\/a>. https:\/\/doi.org\/10.15228\/2020.v10.i01-4.p01<\/p>\n<p><strong>Chicago\/Turabian Style<\/strong><br>Sher, N., N. Shafi, H. Naseem, and M. A. Khan. 2020. &#8220;A Novel Rp-Hplc Method for Simultaneous Estimation of Dorzolamide and Timolol Maleate in Ophthalmic Products&#8221;&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2020.v10.i01-4.p01\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>&nbsp;10, no. 1-4: 1-6<\/a>. https:\/\/doi.org\/10.15228\/2020.v10.i01-4.p01<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"item copyright\">\n<p><a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\"><img decoding=\"async\" src=\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\" alt=\"Creative Commons License\"><\/a><\/p>\n<p>This work is licensed under a&nbsp;<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">Creative Commons Attribution 4.0 International License<\/a>.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/article>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fd77667 e-con-full e-flex e-con e-child\" data-id=\"fd77667\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Research Article | Open Access Volume 10 | Issue 1-4 |&nbsp;https:\/\/doi.org\/10.15228\/2020.v10.i01-4.p01 A Novel Rp-Hplc Method for Simultaneous Estimation of Dorzolamide and Timolol Maleate in Ophthalmic Products N. Sher Department of Chemistry, Faculty of Science, University of Karachi, Karachi, Pakistan 75270 N. Shafi Department of Chemistry, Faculty of Science, University of Karachi, Karachi, Pakistan 75270 H. [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2918","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A Novel Rp-Hplc Method for Simultaneous Estimation of Dorzolamide and Timolol Maleate in Ophthalmic Products - Pakistan Journal of Chemistry<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2020\/08\/31\/pjc-0120\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A Novel Rp-Hplc Method for Simultaneous Estimation of Dorzolamide and Timolol Maleate in Ophthalmic Products - Pakistan Journal of Chemistry\" \/>\n<meta property=\"og:description\" content=\"Research Article | Open Access Volume 10 | Issue 1-4 |&nbsp;https:\/\/doi.org\/10.15228\/2020.v10.i01-4.p01 A Novel Rp-Hplc Method for Simultaneous Estimation of Dorzolamide and Timolol Maleate in Ophthalmic Products N. Sher Department of Chemistry, Faculty of Science, University of Karachi, Karachi, Pakistan 75270 N. Shafi Department of Chemistry, Faculty of Science, University of Karachi, Karachi, Pakistan 75270 H. 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