{"id":2854,"date":"2016-12-31T14:43:00","date_gmt":"2016-12-31T14:43:00","guid":{"rendered":"https:\/\/chempublishers.com\/pjc\/?p=2854"},"modified":"2025-06-14T05:24:41","modified_gmt":"2025-06-14T05:24:41","slug":"pjc-0716","status":"publish","type":"post","link":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/","title":{"rendered":"Transition Metal Complexes of 2-methoxybenzaldehyde-N-(5-chloro-2-oxo-1, 2- dihydro-3H-indol-3-ylidene) hydrazone as New Tyrosinase Inhibitors: Design,Structural Description &amp; In-Vitro Assessment"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2854\" class=\"elementor elementor-2854\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-db9a1b1 e-flex e-con-boxed e-con e-parent\" data-id=\"db9a1b1\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-db78de4 e-con-full e-flex e-con e-child\" data-id=\"db78de4\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b6baed2 elementor-widget elementor-widget-text-editor\" data-id=\"b6baed2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<table border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\"><tbody><tr><td><div><strong>Research Article | Open Access<\/strong><\/div><div class=\"item doi\"><span class=\"value\">Volume 6 | Issue 3-4 |\u00a0<a href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2024\/12\/PJC-v06.i03-4.p02.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.15228\/2016.v06.i03-4.p02<\/a><\/span><\/div><\/td><\/tr><\/tbody><\/table><article class=\"obj_article_details\"><h4>Transition Metal Complexes of 2-methoxybenzaldehyde-N-(5-chloro-2-oxo-1, 2- dihydro-3H-indol-3-ylidene) hydrazone as New Tyrosinase Inhibitors: Design, Structural Description &amp; In-Vitro Assessment<\/h4><div class=\"row\"><div class=\"main_entry\"><p><span class=\"name\">M.A. K. Tanoli<\/span><\/p><p>Department of Chemistry, Faculty of Science, University of Karachi, Pakistan<\/p><p><span class=\"name\">Z. Khan<\/span><\/p><p>Department of Chemistry, Faculty of Science, University of Karachi, Pakistan<\/p><p><span class=\"name\">Z.T. Maqsood<\/span><\/p><p>Department of Chemistry, Faculty of Science, University of Karachi, Pakistan<\/p><p><span class=\"name\">L. Iqbal<\/span><\/p><p>Pakistan Council of Scientific and Industrial Research Laboratories Complex Karachi, Pakistan<\/p><p><span class=\"name\">M. Latif<\/span><\/p><p>Pakistan Council of Scientific and Industrial Research Laboratories Complex Karachi, Pakistan<\/p><p><span class=\"name\">T. Kamal<\/span><\/p><p>Department of Chemistry, Faculty of Science, University of Karachi, Pakistan<\/p><p>\u00a0<\/p><table border=\"0\" width=\"93%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\"><tbody><tr><td align=\"center\" valign=\"top\"><strong>Received<\/strong><br \/>18 Mar, 2016<\/td><td align=\"center\" valign=\"top\"><strong>Accepted<\/strong><br \/>28 Jun, 2016<\/td><td align=\"center\" valign=\"top\"><strong>Published<\/strong><br \/>05 Aug, 2016<\/td><\/tr><\/tbody><\/table><div class=\"item abstract\"><p class=\"ql-align-justify\">The copper-containing tyrosinase is a trans-membrane glycoprotein responsible for catalyzing the rate limiting steps in mammalian melanogenesis, resulting in darker skin color and some dermatological disorders, e.g. melasma, age spots and sites of actinic damage. There are limited studies available on this enzyme in general and limited potent inhibitors are reported in particular. This led us to search for some new potent inhibitors for this enzyme. In this study a new series of coordination compounds from Co (II), Ni (II), Cu (II) and Zn (II) have been synthesized using an isatin derived hydrazone ligand i.e. 2- methoxybenzaldehyde-N-(5-chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazone. Structural characterization of synthesized complexes was carried out by means of employing standard methods e.g. elemental analysis, magnetic susceptibility measurements, molar conductance measurements, IR and UV-Vis. spectroscopy. The characterization suggested that complexes of Co (II), Ni (II) and Zn (II) acquired octahedral geometry with the bi-dentate ligand, while square plane geometry was deduced for Cu (II) complex. A comparative study for screening tyrosinase inhibitory potential was done for all compounds and it was observed that coordination complexes were more effective inhibitors of tyrosinase when compared to the free ligand.<\/p><\/div><div class=\"item abstract\"><div><h3 class=\"label\">How to Cite this paper?<\/h3><div class=\"csl-entry\"><p><strong>APA-7 Style<\/strong><br \/>Tanoli, M.A., Khan, Z., Maqsood, Z.T., Iqbal, L., Latif, M., Kamal, T. (2016). Transition Metal Complexes of 2-methoxybenzaldehyde-N-(5-chloro-2-oxo-1, 2- dihydro-3H-indol-3-ylidene) hydrazone as New Tyrosinase Inhibitors: Design,<br \/>Structural Description &amp; In-Vitro Assessment.\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2016.v06.i03-4.p02\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>, 6(3-4), 42-47<\/a>. https:\/\/doi.org\/10.15228\/2016.v06.i03-4.p02<\/p><p><strong>ACS Style<\/strong><br \/>Tanoli, M.A.; Khan, Z.; Maqsood, Z.T.; Iqbal, L.; Latif, M.; Kamal, T. Transition Metal Complexes of 2-methoxybenzaldehyde-N-(5-chloro-2-oxo-1, 2- dihydro-3H-indol-3-ylidene) hydrazone as New Tyrosinase Inhibitors: Design,<br \/>Structural Description &amp; In-Vitro Assessment.\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2016.v06.i03-4.p02\" target=\"_blank\" rel=\"noopener\"><em>Pak. J. Chem.<\/em>\u00a02016, 6, 42-47<\/a>. https:\/\/doi.org\/10.15228\/2016.v06.i03-4.p02<\/p><p><strong>AMA Style<\/strong><br \/>Tanoli MA, Khan Z, Maqsood ZT, Iqbal L, Latif M, Kamal T. Transition Metal Complexes of 2-methoxybenzaldehyde-N-(5-chloro-2-oxo-1, 2- dihydro-3H-indol-3-ylidene) hydrazone as New Tyrosinase Inhibitors: Design,<br \/>Structural Description &amp; In-Vitro Assessment.\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2016.v06.i03-4.p02\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>. 2016; 6(3-4): 42-47<\/a>. https:\/\/doi.org\/10.15228\/2016.v06.i03-4.p02<\/p><p><strong>Chicago\/Turabian Style<\/strong><br \/>Tanoli, M., A. K., Z. Khan, Z. T. Maqsood, L. Iqbal, M. Latif, and T. Kamal. 2016. &#8220;Transition Metal Complexes of 2-methoxybenzaldehyde-N-(5-chloro-2-oxo-1, 2- dihydro-3H-indol-3-ylidene) hydrazone as New Tyrosinase Inhibitors: Design,<br \/>Structural Description &amp; In-Vitro Assessment&#8221;\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2016.v06.i03-4.p02\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>\u00a06, no. 3-4: 42-47<\/a>. https:\/\/doi.org\/10.15228\/2016.v06.i03-4.p02<\/p><\/div><\/div><\/div><div class=\"item copyright\"><p><a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\"><img decoding=\"async\" src=\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\" alt=\"Creative Commons License\" \/><\/a><\/p><p>This work is licensed under a\u00a0<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">Creative Commons Attribution 4.0 International License<\/a>.<\/p><\/div><\/div><\/div><\/article>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ff223a4 e-con-full e-flex e-con e-child\" data-id=\"ff223a4\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Research Article | Open AccessVolume 6 | Issue 3-4 |\u00a0https:\/\/doi.org\/10.15228\/2016.v06.i03-4.p02 Transition Metal Complexes of 2-methoxybenzaldehyde-N-(5-chloro-2-oxo-1, 2- dihydro-3H-indol-3-ylidene) hydrazone as New Tyrosinase Inhibitors: Design, Structural Description &amp; In-Vitro Assessment M.A. K. Tanoli Department of Chemistry, Faculty of Science, University of Karachi, Pakistan Z. Khan Department of Chemistry, Faculty of Science, University of Karachi, Pakistan Z.T. Maqsood [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2854","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Transition Metal Complexes of 2-methoxybenzaldehyde-N-(5-chloro-2-oxo-1, 2- dihydro-3H-indol-3-ylidene) hydrazone as New Tyrosinase Inhibitors: Design,Structural Description &amp; In-Vitro Assessment - Pakistan Journal of Chemistry<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Transition Metal Complexes of 2-methoxybenzaldehyde-N-(5-chloro-2-oxo-1, 2- dihydro-3H-indol-3-ylidene) hydrazone as New Tyrosinase Inhibitors: Design,Structural Description &amp; In-Vitro Assessment - Pakistan Journal of Chemistry\" \/>\n<meta property=\"og:description\" content=\"Research Article | Open AccessVolume 6 | Issue 3-4 |\u00a0https:\/\/doi.org\/10.15228\/2016.v06.i03-4.p02 Transition Metal Complexes of 2-methoxybenzaldehyde-N-(5-chloro-2-oxo-1, 2- dihydro-3H-indol-3-ylidene) hydrazone as New Tyrosinase Inhibitors: Design, Structural Description &amp; In-Vitro Assessment M.A. K. Tanoli Department of Chemistry, Faculty of Science, University of Karachi, Pakistan Z. Khan Department of Chemistry, Faculty of Science, University of Karachi, Pakistan Z.T. Maqsood [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/\" \/>\n<meta property=\"og:site_name\" content=\"Pakistan Journal of Chemistry\" \/>\n<meta property=\"article:published_time\" content=\"2016-12-31T14:43:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-14T05:24:41+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#\/schema\/person\/5f5f92c274f1346d6f53fa7864e00a01\"},\"headline\":\"Transition Metal Complexes of 2-methoxybenzaldehyde-N-(5-chloro-2-oxo-1, 2- dihydro-3H-indol-3-ylidene) hydrazone as New Tyrosinase Inhibitors: Design,Structural Description &amp; In-Vitro Assessment\",\"datePublished\":\"2016-12-31T14:43:00+00:00\",\"dateModified\":\"2025-06-14T05:24:41+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/\"},\"wordCount\":555,\"publisher\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#organization\"},\"image\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/\",\"url\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/\",\"name\":\"Transition Metal Complexes of 2-methoxybenzaldehyde-N-(5-chloro-2-oxo-1, 2- dihydro-3H-indol-3-ylidene) hydrazone as New Tyrosinase Inhibitors: Design,Structural Description &amp; In-Vitro Assessment - Pakistan Journal of Chemistry\",\"isPartOf\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\",\"datePublished\":\"2016-12-31T14:43:00+00:00\",\"dateModified\":\"2025-06-14T05:24:41+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/#primaryimage\",\"url\":\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\",\"contentUrl\":\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Transition Metal Complexes of 2-methoxybenzaldehyde-N-(5-chloro-2-oxo-1, 2- dihydro-3H-indol-3-ylidene) hydrazone as New Tyrosinase Inhibitors: Design,Structural Description &amp; In-Vitro Assessment\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#website\",\"url\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/\",\"name\":\"Pakistan Journal of Chemistry\",\"description\":\"Pakistan Journal of Chemistry is an international, double-blind,peer-reviewed, open-access Pakistan Based Journal published by Chem Publishers.\",\"publisher\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#organization\",\"name\":\"Pakistan Journal of Chemistry\",\"url\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2024\/12\/cropped-WhatsApp-Image-2024-12-11-at-23.54.08_6d6c4771-1.jpg\",\"contentUrl\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2024\/12\/cropped-WhatsApp-Image-2024-12-11-at-23.54.08_6d6c4771-1.jpg\",\"width\":1129,\"height\":1600,\"caption\":\"Pakistan Journal of Chemistry\"},\"image\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#\/schema\/person\/5f5f92c274f1346d6f53fa7864e00a01\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/ea649f84ccd0f114678afc2b56b41940?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/ea649f84ccd0f114678afc2b56b41940?s=96&d=mm&r=g\",\"caption\":\"admin\"},\"sameAs\":[\"https:\/\/chempublishers.com\"],\"url\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/author\/chempublisherspk\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Transition Metal Complexes of 2-methoxybenzaldehyde-N-(5-chloro-2-oxo-1, 2- dihydro-3H-indol-3-ylidene) hydrazone as New Tyrosinase Inhibitors: Design,Structural Description &amp; In-Vitro Assessment - Pakistan Journal of Chemistry","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/","og_locale":"en_US","og_type":"article","og_title":"Transition Metal Complexes of 2-methoxybenzaldehyde-N-(5-chloro-2-oxo-1, 2- dihydro-3H-indol-3-ylidene) hydrazone as New Tyrosinase Inhibitors: Design,Structural Description &amp; In-Vitro Assessment - Pakistan Journal of Chemistry","og_description":"Research Article | Open AccessVolume 6 | Issue 3-4 |\u00a0https:\/\/doi.org\/10.15228\/2016.v06.i03-4.p02 Transition Metal Complexes of 2-methoxybenzaldehyde-N-(5-chloro-2-oxo-1, 2- dihydro-3H-indol-3-ylidene) hydrazone as New Tyrosinase Inhibitors: Design, Structural Description &amp; In-Vitro Assessment M.A. K. Tanoli Department of Chemistry, Faculty of Science, University of Karachi, Pakistan Z. Khan Department of Chemistry, Faculty of Science, University of Karachi, Pakistan Z.T. Maqsood [&hellip;]","og_url":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/","og_site_name":"Pakistan Journal of Chemistry","article_published_time":"2016-12-31T14:43:00+00:00","article_modified_time":"2025-06-14T05:24:41+00:00","og_image":[{"url":"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png","type":"","width":"","height":""}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Written by":"admin","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/#article","isPartOf":{"@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/"},"author":{"name":"admin","@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#\/schema\/person\/5f5f92c274f1346d6f53fa7864e00a01"},"headline":"Transition Metal Complexes of 2-methoxybenzaldehyde-N-(5-chloro-2-oxo-1, 2- dihydro-3H-indol-3-ylidene) hydrazone as New Tyrosinase Inhibitors: Design,Structural Description &amp; In-Vitro Assessment","datePublished":"2016-12-31T14:43:00+00:00","dateModified":"2025-06-14T05:24:41+00:00","mainEntityOfPage":{"@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/"},"wordCount":555,"publisher":{"@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#organization"},"image":{"@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/#primaryimage"},"thumbnailUrl":"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/","url":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/","name":"Transition Metal Complexes of 2-methoxybenzaldehyde-N-(5-chloro-2-oxo-1, 2- dihydro-3H-indol-3-ylidene) hydrazone as New Tyrosinase Inhibitors: Design,Structural Description &amp; In-Vitro Assessment - Pakistan Journal of Chemistry","isPartOf":{"@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#website"},"primaryImageOfPage":{"@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/#primaryimage"},"image":{"@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/#primaryimage"},"thumbnailUrl":"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png","datePublished":"2016-12-31T14:43:00+00:00","dateModified":"2025-06-14T05:24:41+00:00","breadcrumb":{"@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/#primaryimage","url":"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png","contentUrl":"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png"},{"@type":"BreadcrumbList","@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2016\/12\/31\/pjc-0716\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/"},{"@type":"ListItem","position":2,"name":"Transition Metal Complexes of 2-methoxybenzaldehyde-N-(5-chloro-2-oxo-1, 2- dihydro-3H-indol-3-ylidene) hydrazone as New Tyrosinase Inhibitors: Design,Structural Description &amp; In-Vitro Assessment"}]},{"@type":"WebSite","@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#website","url":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/","name":"Pakistan Journal of Chemistry","description":"Pakistan Journal of Chemistry is an international, double-blind,peer-reviewed, open-access Pakistan Based Journal published by Chem Publishers.","publisher":{"@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#organization","name":"Pakistan Journal of Chemistry","url":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#\/schema\/logo\/image\/","url":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2024\/12\/cropped-WhatsApp-Image-2024-12-11-at-23.54.08_6d6c4771-1.jpg","contentUrl":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2024\/12\/cropped-WhatsApp-Image-2024-12-11-at-23.54.08_6d6c4771-1.jpg","width":1129,"height":1600,"caption":"Pakistan Journal of Chemistry"},"image":{"@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#\/schema\/person\/5f5f92c274f1346d6f53fa7864e00a01","name":"admin","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/ea649f84ccd0f114678afc2b56b41940?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/ea649f84ccd0f114678afc2b56b41940?s=96&d=mm&r=g","caption":"admin"},"sameAs":["https:\/\/chempublishers.com"],"url":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/author\/chempublisherspk\/"}]}},"_links":{"self":[{"href":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-json\/wp\/v2\/posts\/2854","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-json\/wp\/v2\/comments?post=2854"}],"version-history":[{"count":13,"href":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-json\/wp\/v2\/posts\/2854\/revisions"}],"predecessor-version":[{"id":8506,"href":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-json\/wp\/v2\/posts\/2854\/revisions\/8506"}],"wp:attachment":[{"href":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-json\/wp\/v2\/media?parent=2854"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-json\/wp\/v2\/categories?post=2854"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-json\/wp\/v2\/tags?post=2854"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}