{"id":2765,"date":"2015-08-01T13:07:00","date_gmt":"2015-08-01T13:07:00","guid":{"rendered":"https:\/\/chempublishers.com\/pjc\/?p=2765"},"modified":"2025-06-14T05:33:17","modified_gmt":"2025-06-14T05:33:17","slug":"pjc-0815","status":"publish","type":"post","link":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2015\/08\/01\/pjc-0815\/","title":{"rendered":"Synthesis and Antibacterial Activity Study of N-Substituted Acetamide Derivatives of 4-Hydroxy-2-oxo-2H-Chromene"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2765\" class=\"elementor elementor-2765\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-dcd93cc e-flex e-con-boxed e-con e-parent\" data-id=\"dcd93cc\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-f8b6e2d e-con-full e-flex e-con e-child\" data-id=\"f8b6e2d\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c6a9e76 elementor-widget elementor-widget-text-editor\" data-id=\"c6a9e76\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div id=\"pkp_content_main\" class=\"pkp_structure_main\" role=\"main\">\n<div class=\"page page_article\">\n<table border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\">\n<tbody>\n<tr>\n<td>\n<div><strong>Research Article | Open Access<\/strong><\/div>\n<div class=\"item doi\"><span class=\"value\">Volume 5 | Issue 2 |&nbsp;<a href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2024\/12\/PJC-v05.i02.p01.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.15228\/2015.v05.i02.p01<\/a><\/span><\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<article class=\"obj_article_details\">\n<h4>Synthesis and Antibacterial Activity Study of N-Substituted Acetamide Derivatives of 4-Hydroxy-2-oxo-2H-Chromene<\/h4>\n<div class=\"row\">\n<div class=\"main_entry\">\n<p><span class=\"name\">A. U. Rehman<\/span><\/p>\n<p>Department of Chemistry, Government College University, Lahore, Pakistan<\/p>\n<p><span class=\"name\">S. Rasool<\/span><\/p>\n<p>Department of Chemistry, Government College University, Lahore, Pakistan<\/p>\n<p><span class=\"name\">M.A. Abbasi<\/span><\/p>\n<p>Department of Chemistry, Government College University, Lahore, Pakistan<\/p>\n<p><span class=\"name\">S.Z. Siddiqui<\/span><\/p>\n<p>Department of Chemistry, Government College University, Lahore, Pakistan<\/p>\n<p><span class=\"name\">A. Riaz<\/span><\/p>\n<p>Department of Chemistry, Government College University, Lahore, Pakistan<\/p>\n<p><span class=\"name\">A. Tahir<\/span><\/p>\n<p>Department of Chemistry, Government College University, Lahore, Pakistan<\/p>\n<p><span class=\"name\">H.M.A. Asif<\/span><\/p>\n<p>Department of Chemistry, Government College University, Lahore, Pakistan<\/p>\n<p><span class=\"name\">I. Ahmad<\/span><\/p>\n<p>Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan<\/p>\n<table border=\"0\" width=\"93%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\">\n<tbody>\n<tr>\n<td align=\"center\" valign=\"top\"><strong>Received<\/strong><br>12 Mar, 2015<\/td>\n<td align=\"center\" valign=\"top\"><strong>Accepted<\/strong><br>27 Sep, 2015<\/td>\n<td align=\"center\" valign=\"top\"><strong>Published<\/strong><br>12 Dec, 2015<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div class=\"item abstract\">\n<p class=\"ql-align-justify\">The heterocyclic coumarin derivatives are well known for their biological potential. The presented work demonstrates the evaluation of some&nbsp;<em>N<\/em>-substituted acetamoyl derivatives of 4-hydroxy-2-oxo-<em>2H<\/em>-chromene (4)against certain strains of gram bacteria. First,&nbsp;<em>N<\/em>-substituted-2-bromoacetamide, 3a-r, were synthesized by the reaction of aralkyl\/aryl amines, 1a-r, with 2- bromoacetyl bromide (2) in an aqueous medium under definite pH control. In the second step, the resulted electrophiles, 3a-r, were made to react 4in a polar aprotic solvent using a weak base as an activator to synthesize the final&nbsp;<em>N<\/em>-substituted-2-[(2-oxo-<em>2H-<\/em>chromen-4-yl)oxy]acetamide, 5a-r. The synthesis of compounds, 5a-r, was corroborated by TLC initially and spectral data of IR,<sup>1<\/sup>H-NMR and EIMS finally. The MIC results of antibacterial activity rendered these molecules valuable inhibitors of all the bacterial strains taken into account.<\/p>\n<\/div>\n<div class=\"item abstract\">\n<div>\n<h3 class=\"label\">How to Cite this paper?<\/h3>\n<div class=\"csl-entry\">\n<p><strong>APA-7 Style<\/strong><br>Rehman, A.U., Rasool, S., Abbasi, M.A., Siddiqui, S.Z., Riaz, A., Tahir, A., Asif, H.M., Ahmad, . (2015). Synthesis and Antibacterial Activity Study of N-Substituted Acetamide Derivatives of 4-Hydroxy-2-oxo-2H-Chromene.&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2015.v05.i02.p01\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>, 5(2), 50-57<\/a>. https:\/\/doi.org\/10.15228\/2015.v05.i02.p01<\/p>\n<p><strong>ACS Style<\/strong><br>Rehman, A.U.; Rasool, S.; Abbasi, M.A.; Siddiqui, S.Z.; Riaz, A.; Tahir, A.; Asif, H.M.; Ahmad, . Synthesis and Antibacterial Activity Study of N-Substituted Acetamide Derivatives of 4-Hydroxy-2-oxo-2H-Chromene.&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2015.v05.i02.p01\" target=\"_blank\" rel=\"noopener\"><em>Pak. J. Chem.<\/em>&nbsp;2015, 5, 50-57<\/a>. https:\/\/doi.org\/10.15228\/2015.v05.i02.p01<\/p>\n<p><strong>AMA Style<\/strong><br>Rehman AU, Rasool S, Abbasi MA, Siddiqui SZ, Riaz A, Tahir A, Asif HM, Ahmad . Synthesis and Antibacterial Activity Study of N-Substituted Acetamide Derivatives of 4-Hydroxy-2-oxo-2H-Chromene.&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2015.v05.i02.p01\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>. 2015; 5(2): 50-57<\/a>. https:\/\/doi.org\/10.15228\/2015.v05.i02.p01<\/p>\n<p><strong>Chicago\/Turabian Style<\/strong><br>Rehman, Aziz, Ur, S. Rasool, M. A. Abbasi, S. Z. Siddiqui, A. Riaz, A. Tahir, H. M.A. Asif, and I. Ahmad. 2015. &#8220;Synthesis and Antibacterial Activity Study of N-Substituted Acetamide Derivatives of 4-Hydroxy-2-oxo-2H-Chromene&#8221;&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2015.v05.i02.p01\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>&nbsp;5, no. 2: 50-57<\/a>. https:\/\/doi.org\/10.15228\/2015.v05.i02.p01<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"item copyright\">\n<p><a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\"><img decoding=\"async\" src=\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\" alt=\"Creative Commons License\"><\/a><\/p>\n<p>This work is licensed under a&nbsp;<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">Creative Commons Attribution 4.0 International License<\/a>.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/article>\n<\/div>\n<\/div>\n<div class=\"pkp_structure_sidebar left\" role=\"complementary\" aria-label=\"Sidebar\">&nbsp;<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f85cebb e-con-full e-flex e-con e-child\" data-id=\"f85cebb\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Research Article | Open Access Volume 5 | Issue 2 |&nbsp;https:\/\/doi.org\/10.15228\/2015.v05.i02.p01 Synthesis and Antibacterial Activity Study of N-Substituted Acetamide Derivatives of 4-Hydroxy-2-oxo-2H-Chromene A. U. Rehman Department of Chemistry, Government College University, Lahore, Pakistan S. Rasool Department of Chemistry, Government College University, Lahore, Pakistan M.A. Abbasi Department of Chemistry, Government College University, Lahore, Pakistan S.Z. Siddiqui [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2765","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Synthesis and Antibacterial Activity Study of N-Substituted Acetamide Derivatives of 4-Hydroxy-2-oxo-2H-Chromene - Pakistan Journal of Chemistry<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2015\/08\/01\/pjc-0815\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Synthesis and Antibacterial Activity Study of N-Substituted Acetamide Derivatives of 4-Hydroxy-2-oxo-2H-Chromene - Pakistan Journal of Chemistry\" \/>\n<meta property=\"og:description\" content=\"Research Article | Open Access Volume 5 | Issue 2 |&nbsp;https:\/\/doi.org\/10.15228\/2015.v05.i02.p01 Synthesis and Antibacterial Activity Study of N-Substituted Acetamide Derivatives of 4-Hydroxy-2-oxo-2H-Chromene A. U. Rehman Department of Chemistry, Government College University, Lahore, Pakistan S. Rasool Department of Chemistry, Government College University, Lahore, Pakistan M.A. Abbasi Department of Chemistry, Government College University, Lahore, Pakistan S.Z. 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