{"id":2600,"date":"2024-09-01T07:28:00","date_gmt":"2024-09-01T07:28:00","guid":{"rendered":"https:\/\/chempublishers.com\/pjc\/?p=2600"},"modified":"2025-06-14T06:37:13","modified_gmt":"2025-06-14T06:37:13","slug":"pjc-1514","status":"publish","type":"post","link":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2024\/09\/01\/pjc-1514\/","title":{"rendered":"Antibacterial and Enzyme Inhibition Studies of\u00a0N&#8217;-Substituted Benzylidene-2-(2, 4-Dimethylphenoxy) Acetatohydrazides"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2600\" class=\"elementor elementor-2600\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a4decf2 e-flex e-con-boxed e-con e-parent\" data-id=\"a4decf2\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-d5c25fa e-con-full e-flex e-con e-child\" data-id=\"d5c25fa\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5fbdb70 elementor-widget elementor-widget-text-editor\" data-id=\"5fbdb70\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<table border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\">\n<tbody>\n<tr>\n<td>\n<div><strong>Research Article | Open Access<\/strong><\/div>\n<div class=\"item doi\"><span class=\"value\">Volume 4 | Issue 3 |&nbsp;<a href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2025\/01\/PJC-v04.i03.p01.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.15228\/2014.v04.i03.p01<\/a><\/span><\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<article class=\"obj_article_details\">\n<h4>Antibacterial and Enzyme Inhibition Studies of&nbsp;<i>N<\/i>&#8216;-Substituted Benzylidene-2-(2, 4-Dimethylphenoxy) Acetatohydrazides<\/h4>\n<div class=\"row\">\n<div class=\"main_entry\">\n<p><span class=\"name\">S. Nadeem<\/span><\/p>\n<p>Department of Chemistry, School of Science and Technology, University of Management &amp; Technology, Lahore, Pakistan<\/p>\n<p><span class=\"name\">Aziz Ur Rehman<\/span><\/p>\n<p>Department of Chemistry, Government College University, Lahore-54000, Pakistan<\/p>\n<p><span class=\"name\">M.A. Abbasi<\/span><\/p>\n<p>Department of Chemistry, Government College University, Lahore-54000, Pakistan<\/p>\n<p><span class=\"name\">S.Z. Siddiqui<\/span><\/p>\n<p>Department of Chemistry, Government College University, Lahore-54000, Pakistan<\/p>\n<p><span class=\"name\">S. Rasool<\/span><\/p>\n<p>Department of Chemistry, Government College University, Lahore-54000, Pakistan<\/p>\n<p><span class=\"name\">I. Ahmad<\/span><\/p>\n<p>Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan<\/p>\n<p><span class=\"name\">S. Afzal<\/span><\/p>\n<p>Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan<\/p>\n<p><\/p>\n<table border=\"0\" width=\"93%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\">\n<tbody>\n<tr>\n<td align=\"center\" valign=\"top\"><strong>Received<\/strong><br>02 Mar, 2014<\/td>\n<td align=\"center\" valign=\"top\"><strong>Accepted<\/strong><br>21 Sep, 2014<\/td>\n<td align=\"center\" valign=\"top\"><strong>Published<\/strong><br>06 Dec, 2014<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div class=\"item abstract\">\n<p class=\"ql-align-justify\">The molecules bearing azomethine group are known to possess biological activities. In the present work, the synthesis of&nbsp;<em>N&#8217;<\/em>&#8211; Substitutedbenzylidene-2-(2, 4-dimethylphenoxy) acetatohydrazide (5a-d) has been elaborated using 2,4-Dimethylphenol (1) as precursor. The molecule, 1, was converted to ethyl 2-(2,4-dimethylphenoxy)acetate (2) on refluxing with ethyl 2-bromoacetate in ethanol in the presence of KOH. Ethyl ester, 2, was refluxed with hydrated hydrazine (80%) in ethanol to yield 2-(2,4- dimethylphenoxy) acetohydrazide (3). The target molecules, 5a-d, were synthesized by stirring 3 with phenyl\/aryl carboxaldehyde (4a-d) in methanol in the presence of glacial acetic acid. The synthesized molecules were characterized by spectral data and evaluated for antibacterial and anti-enzymatic activities.<\/p>\n<\/div>\n<div class=\"item abstract\">\n<div>\n<h3 class=\"label\">How to Cite this paper?<\/h3>\n<div class=\"csl-entry\">\n<p><strong>APA-7 Style<\/strong><br>Nadeem, S., Rehman, A.U., Abbasi, M.A., Siddiqui, S.Z., Rasool, S., Ahmad, I., Afzal, S. (2014). Antibacterial and Enzyme Inhibition Studies of&nbsp;<i>N<\/i>&#8216;-Substituted Benzylidene-2-(2, 4-Dimethylphenoxy) Acetatohydrazides<br>.&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2014.v04.i03.p01\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>, 4(3), 96-100<\/a>. https:\/\/doi.org\/10.15228\/2014.v04.i03.p01<\/p>\n<p><strong>ACS Style<\/strong><br>Nadeem, S.; Rehman, A.U.; Abbasi, M.A.; Siddiqui, S.Z.; Rasool, S.; Ahmad, I.; Afzal, S. Antibacterial and Enzyme Inhibition Studies of&nbsp;<i>N<\/i>&#8216;-Substituted Benzylidene-2-(2, 4-Dimethylphenoxy) Acetatohydrazides<br>.&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2014.v04.i03.p01\" target=\"_blank\" rel=\"noopener\"><em>Pak. J. Chem.<\/em>&nbsp;2014, 4, 96-100<\/a>. https:\/\/doi.org\/10.15228\/2014.v04.i03.p01<\/p>\n<p><strong>AMA Style<\/strong><br>Nadeem S, Rehman AU, Abbasi MA, Siddiqui SZ, Rasool S, Ahmad I, Afzal S. Antibacterial and Enzyme Inhibition Studies of&nbsp;<i>N<\/i>&#8216;-Substituted Benzylidene-2-(2, 4-Dimethylphenoxy) Acetatohydrazides<br>.&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2014.v04.i03.p01\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>. 2014; 4(3): 96-100<\/a>. https:\/\/doi.org\/10.15228\/2014.v04.i03.p01<\/p>\n<p><strong>Chicago\/Turabian Style<\/strong><br>Nadeem, S., Aziz Ur Rehman, M. A. Abbasi, S. Z. Siddiqui, S. Rasool, I. Ahmad, and S. Afzal. 2014. &#8220;Antibacterial and Enzyme Inhibition Studies of&nbsp;<i>N<\/i>&#8216;-Substituted Benzylidene-2-(2, 4-Dimethylphenoxy) Acetatohydrazides<br>&#8221;&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2014.v04.i03.p01\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>&nbsp;4, no. 3: 96-100<\/a>. https:\/\/doi.org\/10.15228\/2014.v04.i03.p01<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"item copyright\">\n<p><a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\"><img decoding=\"async\" src=\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\" alt=\"Creative Commons License\"><\/a><\/p>\n<p>This work is licensed under a&nbsp;<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">Creative Commons Attribution 4.0 International License<\/a>.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/article>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-eccc7b3 e-con-full e-flex e-con e-child\" data-id=\"eccc7b3\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Research Article | Open Access Volume 4 | Issue 3 |&nbsp;https:\/\/doi.org\/10.15228\/2014.v04.i03.p01 Antibacterial and Enzyme Inhibition Studies of&nbsp;N&#8216;-Substituted Benzylidene-2-(2, 4-Dimethylphenoxy) Acetatohydrazides S. Nadeem Department of Chemistry, School of Science and Technology, University of Management &amp; Technology, Lahore, Pakistan Aziz Ur Rehman Department of Chemistry, Government College University, Lahore-54000, Pakistan M.A. Abbasi Department of Chemistry, Government College [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2600","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Antibacterial and Enzyme Inhibition Studies of\u00a0N&#039;-Substituted Benzylidene-2-(2, 4-Dimethylphenoxy) Acetatohydrazides - Pakistan Journal of Chemistry<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2024\/09\/01\/pjc-1514\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Antibacterial and Enzyme Inhibition Studies of\u00a0N&#039;-Substituted Benzylidene-2-(2, 4-Dimethylphenoxy) Acetatohydrazides - Pakistan Journal of Chemistry\" \/>\n<meta property=\"og:description\" content=\"Research Article | Open Access Volume 4 | Issue 3 |&nbsp;https:\/\/doi.org\/10.15228\/2014.v04.i03.p01 Antibacterial and Enzyme Inhibition Studies of&nbsp;N&#8216;-Substituted Benzylidene-2-(2, 4-Dimethylphenoxy) Acetatohydrazides S. Nadeem Department of Chemistry, School of Science and Technology, University of Management &amp; Technology, Lahore, Pakistan Aziz Ur Rehman Department of Chemistry, Government College University, Lahore-54000, Pakistan M.A. Abbasi Department of Chemistry, Government College [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2024\/09\/01\/pjc-1514\/\" \/>\n<meta property=\"og:site_name\" content=\"Pakistan Journal of Chemistry\" \/>\n<meta property=\"article:published_time\" content=\"2024-09-01T07:28:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-14T06:37:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2024\/09\/01\/pjc-1514\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2024\/09\/01\/pjc-1514\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#\/schema\/person\/5f5f92c274f1346d6f53fa7864e00a01\"},\"headline\":\"Antibacterial and Enzyme Inhibition Studies of\u00a0N&#8217;-Substituted Benzylidene-2-(2, 4-Dimethylphenoxy) Acetatohydrazides\",\"datePublished\":\"2024-09-01T07:28:00+00:00\",\"dateModified\":\"2025-06-14T06:37:13+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2024\/09\/01\/pjc-1514\/\"},\"wordCount\":428,\"publisher\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#organization\"},\"image\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2024\/09\/01\/pjc-1514\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2024\/09\/01\/pjc-1514\/\",\"url\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2024\/09\/01\/pjc-1514\/\",\"name\":\"Antibacterial and Enzyme Inhibition Studies of\u00a0N'-Substituted Benzylidene-2-(2, 4-Dimethylphenoxy) Acetatohydrazides - 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