{"id":2597,"date":"2014-09-25T05:34:00","date_gmt":"2014-09-25T05:34:00","guid":{"rendered":"https:\/\/chempublishers.com\/pjc\/?p=2597"},"modified":"2025-06-14T06:41:17","modified_gmt":"2025-06-14T06:41:17","slug":"pjc-2014","status":"publish","type":"post","link":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2014\/09\/25\/pjc-2014\/","title":{"rendered":"A Review on Antitubercular Activity of Some 2-isonicotinoylhydrazinecarboxamide, 5-(pyridin-4-yl)- 1,3,4-oxadiazol-2-amine,\u00a0N\u00b4-(E)-heteroaromatic-isonicotino-hydrazide and 1-(7-chloroquinolin-4-yl)- 2-(heteroaromatic)methylene hydrazone derivatives"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2597\" class=\"elementor elementor-2597\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3959ccc e-flex e-con-boxed e-con e-parent\" data-id=\"3959ccc\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-d15f0be e-con-full e-flex e-con e-child\" data-id=\"d15f0be\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-92b23c0 elementor-widget elementor-widget-text-editor\" data-id=\"92b23c0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<table border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\">\n<tbody>\n<tr>\n<td>\n<div><strong>Review Article | Open Access<\/strong><\/div>\n<div class=\"item doi\"><span class=\"value\">Volume 4 | Issue 3 |&nbsp;<a href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2025\/01\/PJC-v04.i03.p06.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.15228\/2014.v04.i03.p06<\/a><\/span><\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<article class=\"obj_article_details\">\n<h4>A Review on Antitubercular Activity of Some 2-isonicotinoylhydrazinecarboxamide, 5-(pyridin-4-yl)- 1,3,4-oxadiazol-2-amine,&nbsp;<i>N\u00b4<\/i>-(E)-heteroaromatic-isonicotino-hydrazide and 1-(7-chloroquinolin-4-yl)- 2-(heteroaromatic)methylene hydrazone derivatives<\/h4>\n<div class=\"row\">\n<div class=\"main_entry\">\n<p><span class=\"name\">M. Asif<\/span><\/p>\n<p>Department of Pharmacy, GRD (PG) IMT, Dehradun, India<\/p>\n<p><\/p>\n<table border=\"0\" width=\"93%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\">\n<tbody>\n<tr>\n<td align=\"center\" valign=\"top\"><strong>Received<\/strong><br>07 Mar, 2014<\/td>\n<td align=\"center\" valign=\"top\"><strong>Accepted<\/strong><br>26 Sep, 2014<\/td>\n<td align=\"center\" valign=\"top\"><strong>Published<\/strong><br>11 Dec, 2014<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div class=\"item abstract\">\n<p class=\"ql-align-justify\">The modification of the isoniazid (INH) structure and with N-substituted 5-(pyridine-4-yl)-1,3,4-oxadiazole-2-amine, 5-(pyridin4-yl)-1,3,4-oxadiazol-2-amine derivatives were evaluated in vitro for their anti-tubercular (anti-TB) activity against M. tuberculosis H37Rv,&nbsp;<em>M. avium<\/em>,&nbsp;<em>M. kansasii<\/em>&nbsp;and one clinical isolated strain of&nbsp;<em>M. kansasii<\/em>. 2-Isonicotinoyl-N-(4-octylphenyl) hydrazinecarboxamide displayed an in vitro efficacy comparable to that of INH for M. tuberculosis with MIC of 1\u20132 \u03bcM. Among the halogenated derivatives, the best anti-TB activity was found for 2-isonicotinoyl-N-(2,4,6-trichlorophenyl) hydrazine carboxamide (MIC=4\u03bcM). Most of the hydrazinecarboxamides exhibited significant activity against INH-resistant non tuberculous mycobacteria. Two other series of<em>&nbsp;N\u00b4<\/em>-(E)-heteroaromatic-isonicotino hydrazide derivatives and 1-(7-chloroquinolin4-yl)-2-[(heteroaromatic)methylene] hydrazone derivatives have been for their&nbsp;<em>in vitro<\/em>&nbsp;anti-TB activity against&nbsp;<em>M. tuberculosis<\/em>&nbsp;H37Rv. Several compounds were non cytotoxic and exhibited significant MIC value (3.12, 2.50, 1.25, or 0.60 \u03bcg\/mL) compared with ethambutol (3.12 \u03bcg\/mL) and rifampicin (2.0 \u03bcg\/ml). These results can be considered an important point for the rational design of new leads for anti-TB compounds.<\/p>\n<\/div>\n<div class=\"item abstract\">\n<div>\n<h3 class=\"label\">How to Cite this paper?<\/h3>\n<div class=\"csl-entry\">\n<p><strong>APA-7 Style<\/strong><br>Asif, M. (2014). A Review on Antitubercular Activity of Some 2-isonicotinoylhydrazinecarboxamide, 5-(pyridin-4-yl)- 1,3,4-oxadiazol-2-amine,&nbsp;<i>N\u00b4<\/i>-(E)-heteroaromatic-isonicotino-hydrazide and 1-(7-chloroquinolin-4-yl)- 2-(heteroaromatic)methylene hydrazone derivatives<br>.&nbsp;<a href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2025\/01\/PJC-v04.i03.p06.pdf\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>, 4(3), 132-141<\/a>. https:\/\/doi.org\/10.15228\/2014.v04.i03.p06<\/p>\n<p><strong>ACS Style<\/strong><br>Asif, M. A Review on Antitubercular Activity of Some 2-isonicotinoylhydrazinecarboxamide, 5-(pyridin-4-yl)- 1,3,4-oxadiazol-2-amine,&nbsp;<i>N\u00b4<\/i>-(E)-heteroaromatic-isonicotino-hydrazide and 1-(7-chloroquinolin-4-yl)- 2-(heteroaromatic)methylene hydrazone derivatives<br>.&nbsp;<a href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2025\/01\/PJC-v04.i03.p06.pdf\" target=\"_blank\" rel=\"noopener\"><em>Pak. J. Chem.<\/em>&nbsp;2014, 4, 132-141<\/a>. https:\/\/doi.org\/10.15228\/2014.v04.i03.p06<\/p>\n<p><strong>AMA Style<\/strong><br>Asif M. A Review on Antitubercular Activity of Some 2-isonicotinoylhydrazinecarboxamide, 5-(pyridin-4-yl)- 1,3,4-oxadiazol-2-amine,&nbsp;<i>N\u00b4<\/i>-(E)-heteroaromatic-isonicotino-hydrazide and 1-(7-chloroquinolin-4-yl)- 2-(heteroaromatic)methylene hydrazone derivatives<br>.&nbsp;<a href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2025\/01\/PJC-v04.i03.p06.pdf\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>. 2014; 4(3): 132-141<\/a>. https:\/\/doi.org\/10.15228\/2014.v04.i03.p06<\/p>\n<p><strong>Chicago\/Turabian Style<\/strong><br>Asif, M.. 2014. &#8220;A Review on Antitubercular Activity of Some 2-isonicotinoylhydrazinecarboxamide, 5-(pyridin-4-yl)- 1,3,4-oxadiazol-2-amine,&nbsp;<i>N\u00b4<\/i>-(E)-heteroaromatic-isonicotino-hydrazide and 1-(7-chloroquinolin-4-yl)- 2-(heteroaromatic)methylene hydrazone derivatives<br>&#8221;&nbsp;<a href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2025\/01\/PJC-v04.i03.p06.pdf\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>&nbsp;4, no. 3: 132-141<\/a>. https:\/\/doi.org\/10.15228\/2014.v04.i03.p06<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"item copyright\">\n<p><a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\"><img decoding=\"async\" src=\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\" alt=\"Creative Commons License\"><\/a><\/p>\n<p>This work is licensed under a&nbsp;<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">Creative Commons Attribution 4.0 International License<\/a>.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/article>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-68cc110 e-con-full e-flex e-con e-child\" data-id=\"68cc110\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Review Article | Open Access Volume 4 | Issue 3 |&nbsp;https:\/\/doi.org\/10.15228\/2014.v04.i03.p06 A Review on Antitubercular Activity of Some 2-isonicotinoylhydrazinecarboxamide, 5-(pyridin-4-yl)- 1,3,4-oxadiazol-2-amine,&nbsp;N\u00b4-(E)-heteroaromatic-isonicotino-hydrazide and 1-(7-chloroquinolin-4-yl)- 2-(heteroaromatic)methylene hydrazone derivatives M. Asif Department of Pharmacy, GRD (PG) IMT, Dehradun, India Received07 Mar, 2014 Accepted26 Sep, 2014 Published11 Dec, 2014 The modification of the isoniazid (INH) structure and with N-substituted [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2597","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A Review on Antitubercular Activity of Some 2-isonicotinoylhydrazinecarboxamide, 5-(pyridin-4-yl)- 1,3,4-oxadiazol-2-amine,\u00a0N\u00b4-(E)-heteroaromatic-isonicotino-hydrazide and 1-(7-chloroquinolin-4-yl)- 2-(heteroaromatic)methylene hydrazone derivatives - Pakistan Journal of Chemistry<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2014\/09\/25\/pjc-2014\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A Review on Antitubercular Activity of Some 2-isonicotinoylhydrazinecarboxamide, 5-(pyridin-4-yl)- 1,3,4-oxadiazol-2-amine,\u00a0N\u00b4-(E)-heteroaromatic-isonicotino-hydrazide and 1-(7-chloroquinolin-4-yl)- 2-(heteroaromatic)methylene hydrazone derivatives - Pakistan Journal of Chemistry\" \/>\n<meta property=\"og:description\" content=\"Review Article | Open Access Volume 4 | Issue 3 |&nbsp;https:\/\/doi.org\/10.15228\/2014.v04.i03.p06 A Review on Antitubercular Activity of Some 2-isonicotinoylhydrazinecarboxamide, 5-(pyridin-4-yl)- 1,3,4-oxadiazol-2-amine,&nbsp;N\u00b4-(E)-heteroaromatic-isonicotino-hydrazide and 1-(7-chloroquinolin-4-yl)- 2-(heteroaromatic)methylene hydrazone derivatives M. Asif Department of Pharmacy, GRD (PG) IMT, Dehradun, India Received07 Mar, 2014 Accepted26 Sep, 2014 Published11 Dec, 2014 The modification of the isoniazid (INH) structure and with N-substituted [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2014\/09\/25\/pjc-2014\/\" \/>\n<meta property=\"og:site_name\" content=\"Pakistan Journal of Chemistry\" \/>\n<meta property=\"article:published_time\" content=\"2014-09-25T05:34:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-14T06:41:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2014\/09\/25\/pjc-2014\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2014\/09\/25\/pjc-2014\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#\/schema\/person\/5f5f92c274f1346d6f53fa7864e00a01\"},\"headline\":\"A Review on Antitubercular Activity of Some 2-isonicotinoylhydrazinecarboxamide, 5-(pyridin-4-yl)- 1,3,4-oxadiazol-2-amine,\u00a0N\u00b4-(E)-heteroaromatic-isonicotino-hydrazide and 1-(7-chloroquinolin-4-yl)- 2-(heteroaromatic)methylene hydrazone derivatives\",\"datePublished\":\"2014-09-25T05:34:00+00:00\",\"dateModified\":\"2025-06-14T06:41:17+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2014\/09\/25\/pjc-2014\/\"},\"wordCount\":466,\"publisher\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/#organization\"},\"image\":{\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2014\/09\/25\/pjc-2014\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2014\/09\/25\/pjc-2014\/\",\"url\":\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2014\/09\/25\/pjc-2014\/\",\"name\":\"A Review on Antitubercular Activity of Some 2-isonicotinoylhydrazinecarboxamide, 5-(pyridin-4-yl)- 1,3,4-oxadiazol-2-amine,\u00a0N\u00b4-(E)-heteroaromatic-isonicotino-hydrazide and 1-(7-chloroquinolin-4-yl)- 2-(heteroaromatic)methylene hydrazone derivatives - 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