{"id":2592,"date":"2014-12-01T11:55:00","date_gmt":"2014-12-01T11:55:00","guid":{"rendered":"https:\/\/chempublishers.com\/pjc\/?p=2592"},"modified":"2025-06-14T06:49:38","modified_gmt":"2025-06-14T06:49:38","slug":"pjc-2214","status":"publish","type":"post","link":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2014\/12\/01\/pjc-2214\/","title":{"rendered":"Synthesis and Biological Screening of N-(Dimethylphenyl Substituted)-N-Ethyl\/Benzyl4-Chlorobenzenesulfonamide Derivatives"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2592\" class=\"elementor elementor-2592\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0aeaef2 e-flex e-con-boxed e-con e-parent\" data-id=\"0aeaef2\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7fddae4 e-con-full e-flex e-con e-child\" data-id=\"7fddae4\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4474603 elementor-widget elementor-widget-text-editor\" data-id=\"4474603\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<table border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\">\n<tbody>\n<tr>\n<td>\n<div><strong>Research Article | Open Access<\/strong><\/div>\n<div class=\"item doi\"><span class=\"value\">Volume 4 | Issue 4 |&nbsp;<a href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2024\/12\/PJC-v04.i04.p01.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.15228\/2014.v04.i04.p01<\/a><\/span><\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<article class=\"obj_article_details\">\n<h4>Synthesis and Biological Screening of N-(Dimethylphenyl Substituted)-N-Ethyl\/Benzyl4-Chlorobenzenesulfonamide Derivatives<\/h4>\n<div class=\"row\">\n<div class=\"main_entry\">\n<p><span class=\"name\">Aziz Ur Rehman<\/span><\/p>\n<p>Department of Chemistry, Government College University, Lahore, Pakistan<\/p>\n<p><span class=\"name\">I. Ahmad<\/span><\/p>\n<p>Department of Chemistry, Government College University, Lahore, Pakistan<\/p>\n<p><span class=\"name\">M.A. Abbasi<\/span><\/p>\n<p>Department of Chemistry, Government College University, Lahore, Pakistan<\/p>\n<p><span class=\"name\">S. Z. Siddiqui<\/span><\/p>\n<p>Department of Chemistry, Government College University, Lahore, Pakistan<\/p>\n<p><span class=\"name\">K. Nafeesa<\/span><\/p>\n<p>Department of Chemistry, Government College University, Lahore, Pakistan<\/p>\n<p><span class=\"name\">A. Sattar<\/span><\/p>\n<p>Department of Chemistry, Government College University, Lahore, Pakistan<\/p>\n<p><span class=\"name\">I. Ahmed<\/span><\/p>\n<p>Department of Pharmac, The Islamia University of Bahawalpur, Pakistan<\/p>\n<p><span class=\"name\">S. Afzal<\/span><\/p>\n<p>Department of Pharmac, The Islamia University of Bahawalpur, Pakistan<\/p>\n<div class=\"item abstract\">\n<p class=\"ql-align-justify\">In the undertaken research, a number of N-dimethylphenyl substituted derivatives of N-ethyl\/benzyl-4-chlorobenzenesulfonamide, (6a-f &amp; 7a-f) was synthesized and also estimated for their biological potential. The reaction of 4-chlorobenzenesulfonyl chloride with different dimethyl substituted phenyl amine (2a-f) in the presence of basic aqueous media yielded N-[(Dimethyl substituted) phenyl]-4-chlorobenzenesulfonamides (3a-f). The targeted compounds 6a-f &amp; 7a-f were synthesized by the reaction of compounds 3a-f with electrophiles, ethyl bromide\/benzyl chloride in the presence of base NaH and polar aprotic solvent (DMF). The structures of the compounds were elucidated through&nbsp;<sup>1<\/sup>H-NMR, IR and mass spectral data. The synthesized compounds (6a-f &amp; 7a-f) were screened against Gram-negative &amp; Gram-positive bacteria and also subjected for enzyme inhibition potential against lipoxygenase and chymotrypsin enzymes and almost all the compounds exhibited moderate to good activities.<\/p>\n<\/div>\n<div class=\"item abstract\">\n<div>\n<h3 class=\"label\">How to Cite this paper?<\/h3>\n<div class=\"csl-entry\">\n<p><strong>APA-7 Style<\/strong><br>Rehman, A.U., Ahmad, I., Abbasi, M.A., Siddiqui, S.Z., Nafeesa, K., Sattar, A., Ahmed, I., Afzal, S. (2014). Synthesis and Biological Screening of N-(Dimethylphenyl Substituted)-N-Ethyl\/Benzyl4-Chlorobenzenesulfonamide Derivatives.&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2014.v04.i04.p01\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>, 4(4), 153-160<\/a>. https:\/\/doi.org\/10.15228\/2014.v04.i04.p01<\/p>\n<p><strong>ACS Style<\/strong><br>Rehman, A.U.; Ahmad, I.; Abbasi, M.A.; Siddiqui, S.Z.; Nafeesa, K.; Sattar, A.; Ahmed, I.; Afzal, S. Synthesis and Biological Screening of N-(Dimethylphenyl Substituted)-N-Ethyl\/Benzyl4-Chlorobenzenesulfonamide Derivatives.&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2014.v04.i04.p01\" target=\"_blank\" rel=\"noopener\"><em>Pak. J. Chem.<\/em>&nbsp;2014, 4, 153-160<\/a>. https:\/\/doi.org\/10.15228\/2014.v04.i04.p01<\/p>\n<p><strong>AMA Style<\/strong><br>Rehman AU, Ahmad I, Abbasi MA, Siddiqui SZ, Nafeesa K, Sattar A, Ahmed I, Afzal S. Synthesis and Biological Screening of N-(Dimethylphenyl Substituted)-N-Ethyl\/Benzyl4-Chlorobenzenesulfonamide Derivatives.&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2014.v04.i04.p01\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>. 2014; 4(4): 153-160<\/a>. https:\/\/doi.org\/10.15228\/2014.v04.i04.p01<\/p>\n<p><strong>Chicago\/Turabian Style<\/strong><br>Rehman, Aziz, Ur, I. Ahmad, M. A. Abbasi, S. Z. Siddiqui, K. Nafeesa, A. Sattar, I. Ahmed, and S. Afzal. 2014. &#8220;Synthesis and Biological Screening of N-(Dimethylphenyl Substituted)-N-Ethyl\/Benzyl4-Chlorobenzenesulfonamide Derivatives&#8221;&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2014.v04.i04.p01\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>&nbsp;4, no. 4: 153-160<\/a>. https:\/\/doi.org\/10.15228\/2014.v04.i04.p01<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"item copyright\">\n<p><a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\"><img decoding=\"async\" src=\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\" alt=\"Creative Commons License\"><\/a><\/p>\n<p>This work is licensed under a&nbsp;<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">Creative Commons Attribution 4.0 International License<\/a>.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/article>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fb171f1 e-con-full e-flex e-con e-child\" data-id=\"fb171f1\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Research Article | Open Access Volume 4 | Issue 4 |&nbsp;https:\/\/doi.org\/10.15228\/2014.v04.i04.p01 Synthesis and Biological Screening of N-(Dimethylphenyl Substituted)-N-Ethyl\/Benzyl4-Chlorobenzenesulfonamide Derivatives Aziz Ur Rehman Department of Chemistry, Government College University, Lahore, Pakistan I. Ahmad Department of Chemistry, Government College University, Lahore, Pakistan M.A. Abbasi Department of Chemistry, Government College University, Lahore, Pakistan S. Z. Siddiqui Department of [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2592","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Synthesis and Biological Screening of N-(Dimethylphenyl Substituted)-N-Ethyl\/Benzyl4-Chlorobenzenesulfonamide Derivatives - Pakistan Journal of Chemistry<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2014\/12\/01\/pjc-2214\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Synthesis and Biological Screening of N-(Dimethylphenyl Substituted)-N-Ethyl\/Benzyl4-Chlorobenzenesulfonamide Derivatives - Pakistan Journal of Chemistry\" \/>\n<meta property=\"og:description\" content=\"Research Article | Open Access Volume 4 | Issue 4 |&nbsp;https:\/\/doi.org\/10.15228\/2014.v04.i04.p01 Synthesis and Biological Screening of N-(Dimethylphenyl Substituted)-N-Ethyl\/Benzyl4-Chlorobenzenesulfonamide Derivatives Aziz Ur Rehman Department of Chemistry, Government College University, Lahore, Pakistan I. 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