{"id":2587,"date":"2014-12-05T05:18:00","date_gmt":"2014-12-05T05:18:00","guid":{"rendered":"https:\/\/chempublishers.com\/pjc\/?p=2587"},"modified":"2025-06-14T06:50:16","modified_gmt":"2025-06-14T06:50:16","slug":"pjc-2314","status":"publish","type":"post","link":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2014\/12\/05\/pjc-2314\/","title":{"rendered":"Synthesis of Some N-Substituted Sulfonamides Derived from Moringine as Lipoxygenase Inhibitors"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2587\" class=\"elementor elementor-2587\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-93a1905 e-flex e-con-boxed e-con e-parent\" data-id=\"93a1905\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-e20da9c e-con-full e-flex e-con e-child\" data-id=\"e20da9c\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-633d3b3 elementor-widget elementor-widget-text-editor\" data-id=\"633d3b3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<table border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\">\n<tbody>\n<tr>\n<td>\n<div><strong>Research Article | Open Access<\/strong><\/div>\n<div class=\"item doi\"><span class=\"value\">Volume 4 | Issue 4 |&nbsp;<a href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2024\/12\/PJC-v04.i04.p02.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.15228\/2014.v04.i04.p02<\/a><\/span><\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<article class=\"obj_article_details\">\n<h4>Synthesis of Some N-Substituted Sulfonamides Derived from Moringine as Lipoxygenase Inhibitors<\/h4>\n<div class=\"row\">\n<div class=\"main_entry\">\n<p><span class=\"name\">M.A. Abbasi<\/span><\/p>\n<p>Department of Chemistry, Government College University, Lahore, Pakistan<\/p>\n<p><span class=\"name\">U. Mujahid<\/span><\/p>\n<p>Department of Chemistry, Government College University, Lahore, Pakistan<\/p>\n<p><span class=\"name\">Aziz Ur Rehman<\/span><\/p>\n<p>Department of Chemistry, Government College University, Lahore, Pakistan<\/p>\n<p><span class=\"name\">S. Rasool<\/span><\/p>\n<p>Department of Chemistry, Government College University, Lahore, Pakistan<\/p>\n<p><span class=\"name\">K. M. Khan<\/span><\/p>\n<p>HEJ, Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan<\/p>\n<p><span class=\"name\">M. Ashraf<\/span><\/p>\n<p>Department of Biochemistry and Biotechnology; The Islamia University of Bahawalpur, Pakistan<\/p>\n<p><\/p>\n<table border=\"0\" width=\"93%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\">\n<tbody>\n<tr>\n<td align=\"center\" valign=\"top\"><strong>Received<\/strong><br>12 Apr, 2014<\/td>\n<td align=\"center\" valign=\"top\"><strong>Accepted<\/strong><br>13 Oct, 2014<\/td>\n<td align=\"center\" valign=\"top\"><strong>Published<\/strong><br>15 Nov, 2014<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div class=\"item abstract\">\n<p class=\"ql-align-justify\">Sulfonamides belong to an emerging class having good inhibitory effects. In the present work, a series of N-substituted derivatives of N-benzyl-4-chlorobenzenesulfonamide have been synthesized. The reaction of moringine (benzylamine; 1) with 4- chlorobenzenesulfonyl chloride (2) in aqueous medium yielded the parent molecule, N-benzyl-4-chlorobenzenesulfonamide (3). Alkyl\/aralkyl halides, 4a-m, were reacted with 3 in polar aprotic medium to produce N-substituted derivatives, 5a-m. These synthesized products were characterized by&nbsp;<sup>1<\/sup>H-NMR, IR and EI-MS spectra and screened against lipoxygenase (LOX) enzyme. These were found to be moderate inhibitors of this enzyme and could find their use as therapeutic agent for various inflammatory ailments.<\/p>\n<\/div>\n<div class=\"item abstract\">\n<div>\n<h3 class=\"label\">How to Cite this paper?<\/h3>\n<div class=\"csl-entry\">\n<p><strong>APA-7 Style<\/strong><br>Abbasi, M.A., Mujahid, U., Rehman, A.U., Rasool, S., Khan, K.M., Ashraf, M. (2014). Synthesis of Some N-Substituted Sulfonamides Derived from Moringine as Lipoxygenase Inhibitors<br>.&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2014.v04.i04.p02\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>, 4(4), 161-166<\/a>. https:\/\/doi.org\/10.15228\/2014.v04.i04.p02<\/p>\n<p><strong>ACS Style<\/strong><br>Abbasi, M.A.; Mujahid, U.; Rehman, A.U.; Rasool, S.; Khan, K.M.; Ashraf, M. Synthesis of Some N-Substituted Sulfonamides Derived from Moringine as Lipoxygenase Inhibitors<br>.&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2014.v04.i04.p02\" target=\"_blank\" rel=\"noopener\"><em>Pak. J. Chem.<\/em>&nbsp;2014, 4, 161-166<\/a>. https:\/\/doi.org\/10.15228\/2014.v04.i04.p02<\/p>\n<p><strong>AMA Style<\/strong><br>Abbasi MA, Mujahid U, Rehman AU, Rasool S, Khan KM, Ashraf M. Synthesis of Some N-Substituted Sulfonamides Derived from Moringine as Lipoxygenase Inhibitors<br>.&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2014.v04.i04.p02\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>. 2014; 4(4): 161-166<\/a>. https:\/\/doi.org\/10.15228\/2014.v04.i04.p02<\/p>\n<p><strong>Chicago\/Turabian Style<\/strong><br>Abbasi, M., A., U. Mujahid, Aziz Ur Rehman, S. Rasool, K. M. Khan, and M. Ashraf. 2014. &#8220;Synthesis of Some N-Substituted Sulfonamides Derived from Moringine as Lipoxygenase Inhibitors<br>&#8221;&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2014.v04.i04.p02\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>&nbsp;4, no. 4: 161-166<\/a>. https:\/\/doi.org\/10.15228\/2014.v04.i04.p02<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"item copyright\">\n<p><a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\"><img decoding=\"async\" src=\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\" alt=\"Creative Commons License\"><\/a><\/p>\n<p>This work is licensed under a&nbsp;<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">Creative Commons Attribution 4.0 International License<\/a>.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/article>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b9f55d9 e-con-full e-flex e-con e-child\" data-id=\"b9f55d9\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Research Article | Open Access Volume 4 | Issue 4 |&nbsp;https:\/\/doi.org\/10.15228\/2014.v04.i04.p02 Synthesis of Some N-Substituted Sulfonamides Derived from Moringine as Lipoxygenase Inhibitors M.A. Abbasi Department of Chemistry, Government College University, Lahore, Pakistan U. Mujahid Department of Chemistry, Government College University, Lahore, Pakistan Aziz Ur Rehman Department of Chemistry, Government College University, Lahore, Pakistan S. Rasool [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2587","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Synthesis of Some N-Substituted Sulfonamides Derived from Moringine as Lipoxygenase Inhibitors - Pakistan Journal of Chemistry<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2014\/12\/05\/pjc-2314\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Synthesis of Some N-Substituted Sulfonamides Derived from Moringine as Lipoxygenase Inhibitors - Pakistan Journal of Chemistry\" \/>\n<meta property=\"og:description\" content=\"Research Article | Open Access Volume 4 | Issue 4 |&nbsp;https:\/\/doi.org\/10.15228\/2014.v04.i04.p02 Synthesis of Some N-Substituted Sulfonamides Derived from Moringine as Lipoxygenase Inhibitors M.A. Abbasi Department of Chemistry, Government College University, Lahore, Pakistan U. 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