{"id":2219,"date":"2011-12-05T14:30:00","date_gmt":"2011-12-05T14:30:00","guid":{"rendered":"https:\/\/chempublishers.com\/pjc\/?p=2219"},"modified":"2025-06-13T11:25:44","modified_gmt":"2025-06-13T11:25:44","slug":"pjc-2711","status":"publish","type":"post","link":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2011\/12\/05\/pjc-2711\/","title":{"rendered":"The Therapeutic role of Magnesium in different depressive syndromes of the male population comprising of different age groups"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2219\" class=\"elementor elementor-2219\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f9b2f24 e-flex e-con-boxed e-con e-parent\" data-id=\"f9b2f24\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7c93e84 e-con-full e-flex e-con e-child\" data-id=\"7c93e84\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6e22c5c elementor-widget elementor-widget-text-editor\" data-id=\"6e22c5c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<table border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\"><tbody><tr><td><div><strong>Research Article | Open Access<\/strong><\/div><div class=\"item doi\"><span class=\"value\">Volume 1 | Issue 4 |\u00a0<a href=\"https:\/\/chempublishers.com\/pjc\/wp-content\/uploads\/sites\/2\/2024\/10\/185_1.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.15228\/2011.v01.i04.p03<\/a><\/span><\/div><\/td><\/tr><\/tbody><\/table><article class=\"obj_article_details\"><h4 class=\"page_title\">The Therapeutic role of Magnesium in different depressive syndromes of the male population comprising of different age groups<\/h4><div class=\"row\"><div class=\"main_entry\"><p><span class=\"name\">N. Bano<\/span><\/p><p>Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan<\/p><p><span class=\"name\">R. Najam<\/span><\/p><p>Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan<\/p><p><span class=\"name\">S. Naeem<\/span><\/p><p>Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan<\/p><table border=\"0\" width=\"93%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\"><tbody><tr><td align=\"center\" valign=\"top\"><strong>Received<\/strong><br \/>27 Mar, 2011<\/td><td align=\"center\" valign=\"top\"><strong>Accepted<\/strong><br \/>27 Jun, 2011<\/td><td align=\"center\" valign=\"top\"><strong>Published<\/strong><br \/>27 Dec, 2011<\/td><\/tr><\/tbody><\/table><div class=\"item abstract\"><p class=\"ql-align-justify\">The basic and fundamental role of Mg as being the second most abundant intercellular cation is established in various studies. It is identified as a divalent metal cofactor in over 300 enzymatic reactions involving energy metabolism and protein and nucleic acid synthesis. The biological function is identified in neuromuscular excitability. Mg ion regulates calcium ion flow in neuronal channels, helping to regulate neuronal Nitric Oxide production\u00a0<sup>1<\/sup>\u00a0. Mg deficiency causes NMDA coupled Calcium channels to be biased towards opening, causing neuronal injury &amp; neurological dysfunction, which may appear to humans as major depression. The present study confirms a reduction in the symptoms of depression found in the male population comprising of different age group by Mg treatment. CSF Mg has been found low in treatment resistant suicidal depression. Brain Mg is also low in TRD using phosphorous nuclear magnetic resonance Spectroscopy<sup>2<\/sup>. A 2009 randomized clinical trial shows that Mg therapy was an effective as TCAs in depressed diabetics. Increase in brain Mg enhances both short term synaptic facilitation and long term potentiation and improves learning and memory function<sup>3<\/sup>. The present study is based on findings that male subjects diagnosed as depressed showed a marked reduction in behavioral and somatic features of the disease after administration of Magnesium supplement. Physiological and somatic anxiety was also alleviated in a certain age group which displayed recovery from Insomnia and agitation. Suicidal tendency was also negative in all age groups. This study focuses on the behavioral and somatic responses pertaining to brain biochemical changes induced by Magnesium therapy.<\/p><\/div><div class=\"item abstract\"><div><h3 class=\"label\">How to Cite this paper?<\/h3><div class=\"csl-entry\"><p><strong>APA-7 Style<\/strong><br \/>Bano, N., Najam, R., Naeem, S. (2011). The Therapeutic role of Magnesium in different depressive syndromes of the male population comprising of different age groups.\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2011.v01.i04.p03\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>, 1(4), 161-163<\/a>. https:\/\/doi.org\/10.15228\/2011.v01.i04.p03<\/p><p><strong>ACS Style<\/strong><br \/>Bano, N.; Najam, R.; Naeem, S. The Therapeutic role of Magnesium in different depressive syndromes of the male population comprising of different age groups.\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2011.v01.i04.p03\" target=\"_blank\" rel=\"noopener\"><em>Pak. J. Chem.<\/em>\u00a02011, 1, 161-163<\/a>. https:\/\/doi.org\/10.15228\/2011.v01.i04.p03<\/p><p><strong>AMA Style<\/strong><br \/>Bano N, Najam R, Naeem S. The Therapeutic role of Magnesium in different depressive syndromes of the male population comprising of different age groups.\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2011.v01.i04.p03\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>. 2011; 1(4): 161-163<\/a>. https:\/\/doi.org\/10.15228\/2011.v01.i04.p03<\/p><p><strong>Chicago\/Turabian Style<\/strong><br \/>Bano, N., R. Najam, and S. Naeem. 2011. &#8220;The Therapeutic role of Magnesium in different depressive syndromes of the male population comprising of different age groups&#8221;\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2011.v01.i04.p03\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>\u00a01, no. 4: 161-163<\/a>. https:\/\/doi.org\/10.15228\/2011.v01.i04.p03<\/p><\/div><\/div><\/div><div class=\"item copyright\"><p><a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\"><img decoding=\"async\" src=\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\" alt=\"Creative Commons License\" \/><\/a><\/p><p>This work is licensed under a\u00a0<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">Creative Commons Attribution 4.0 International License<\/a>.<\/p><\/div><\/div><\/div><\/article>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bc45127 e-con-full e-flex e-con e-child\" data-id=\"bc45127\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Research Article | Open AccessVolume 1 | Issue 4 |\u00a0https:\/\/doi.org\/10.15228\/2011.v01.i04.p03 The Therapeutic role of Magnesium in different depressive syndromes of the male population comprising of different age groups N. Bano Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan R. Najam Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan S. Naeem Faculty [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2219","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The Therapeutic role of Magnesium in different depressive syndromes of the male population comprising of different age groups - Pakistan Journal of Chemistry<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2011\/12\/05\/pjc-2711\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Therapeutic role of Magnesium in different depressive syndromes of the male population comprising of different age groups - Pakistan Journal of Chemistry\" \/>\n<meta property=\"og:description\" content=\"Research Article | Open AccessVolume 1 | Issue 4 |\u00a0https:\/\/doi.org\/10.15228\/2011.v01.i04.p03 The Therapeutic role of Magnesium in different depressive syndromes of the male population comprising of different age groups N. 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