{"id":2169,"date":"2011-09-10T13:30:00","date_gmt":"2011-09-10T13:30:00","guid":{"rendered":"https:\/\/chempublishers.com\/pjc\/?p=2169"},"modified":"2025-06-13T11:13:17","modified_gmt":"2025-06-13T11:13:17","slug":"pjc-2011","status":"publish","type":"post","link":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2011\/09\/10\/pjc-2011\/","title":{"rendered":"Evaluation of Drug Induced Neuronal Damage in Rats"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2169\" class=\"elementor elementor-2169\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4e3a5dd e-flex e-con-boxed e-con e-parent\" data-id=\"4e3a5dd\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-dd1703b e-con-full e-flex e-con e-child\" data-id=\"dd1703b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-917094e elementor-widget elementor-widget-text-editor\" data-id=\"917094e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<table border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\"><tbody><tr><td><div><strong>Research Article | Open Access<\/strong><\/div><div class=\"item doi\"><span class=\"value\">Volume 1 | Issue 3 |\u00a0<a href=\"https:\/\/chempublishers.com\/pjc\/wp-content\/uploads\/sites\/2\/2024\/10\/176_1.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.15228\/2011.v01.i03.p04<\/a><\/span><\/div><\/td><\/tr><\/tbody><\/table><article class=\"obj_article_details\"><h4 class=\"page_title\">Evaluation of Drug Induced Neuronal Damage in Rats<\/h4><div class=\"row\"><div class=\"main_entry\"><p><span class=\"name\">R. Najam<\/span><\/p><p>Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan<\/p><p><span class=\"name\">S. Naeem<\/span><\/p><p>Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan<\/p><p><span class=\"name\">F. Aleem<\/span><\/p><p>Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan<\/p><p><span class=\"name\">N. Bano<\/span><\/p><p>Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan<\/p><table border=\"0\" width=\"93%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\"><tbody><tr><td align=\"center\" valign=\"top\"><strong>Received<\/strong><br \/>18 Mar, 2011<\/td><td align=\"center\" valign=\"top\"><strong>Accepted<\/strong><br \/>18 Jun, 2011<\/td><td align=\"center\" valign=\"top\"><strong>Published<\/strong><br \/>18 Dec, 2011<\/td><\/tr><\/tbody><\/table><div class=\"item abstract\"><p class=\"ql-align-justify\">Previous somatic treatments of schizophrenia include continuous sleep therapy, insulin coma, electroconvulsive therapy &amp; psychosurgical treatments. These options are usually associated with serious adverse effects. Over the ensuing 50 years, several classes of compounds with anti-psychotic activity have been developed. Fluphenazine is one of the typical antipsychotic drugs, use to treat schizophrenia and other mental disorders. The present study was designed to evaluate various neuronal damages &amp; behavioral impairment caused by the intramuscular administration of fluphenazine deconate in the rats. Rats were treated with 5mg\/0.2ml fluphenazine IM for one month. This research work revealed a definite pattern, sequence and manifestation of the adverse effects produced by the drug during the whole period. Fluphenazine treated rats have shown a significant decreased loco motor activity, some neuronal damage &amp; cognitive impairment, as rats developed rotational behavior &amp; ptosis after the chronic administration of the drug which is a clear cut indication of neuronal stress as compare to the control rats. The inhibition of the locomotor activity is may be due to decreased level of dopamine, GABA ergic hypofunction &amp; oxidative stress at basal ganglia. Cognitive impairment &amp; rotational behavior in fluphenazine treated rats clearly revealed that this drug may impart neuronal damage in rats.<\/p><\/div><div class=\"item abstract\"><div><h3 class=\"label\">How to Cite this paper?<\/h3><div class=\"csl-entry\"><p><strong>APA-7 Style<\/strong><br \/>Najam, R., Naeem, S., Aleem, F., Bano, N. (2011). Evaluation of Drug Induced Neuronal Damage in Rats.\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2011.v01.i03.p04\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>, 1(3), 126-131<\/a>. https:\/\/doi.org\/10.15228\/2011.v01.i03.p04<\/p><p><strong>ACS Style<\/strong><br \/>Najam, R.; Naeem, S.; Aleem, F.; Bano, N. Evaluation of Drug Induced Neuronal Damage in Rats.\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2011.v01.i03.p04\" target=\"_blank\" rel=\"noopener\"><em>Pak. J. Chem.<\/em>\u00a02011, 1, 126-131<\/a>. https:\/\/doi.org\/10.15228\/2011.v01.i03.p04<\/p><p><strong>AMA Style<\/strong><br \/>Najam R, Naeem S, Aleem F, Bano N. Evaluation of Drug Induced Neuronal Damage in Rats.\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2011.v01.i03.p04\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>. 2011; 1(3): 126-131<\/a>. https:\/\/doi.org\/10.15228\/2011.v01.i03.p04<\/p><p><strong>Chicago\/Turabian Style<\/strong><br \/>Najam, R., S. Naeem, F. Aleem, and N. Bano. 2011. &#8220;Evaluation of Drug Induced Neuronal Damage in Rats&#8221;\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2011.v01.i03.p04\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>\u00a01, no. 3: 126-131<\/a>. https:\/\/doi.org\/10.15228\/2011.v01.i03.p04<\/p><\/div><\/div><\/div><div class=\"item copyright\"><p><a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\"><img decoding=\"async\" src=\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\" alt=\"Creative Commons License\" \/><\/a><\/p><p>This work is licensed under a\u00a0<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">Creative Commons Attribution 4.0 International License<\/a>.<\/p><\/div><\/div><\/div><\/article>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9ca4a61 e-con-full e-flex e-con e-child\" data-id=\"9ca4a61\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Research Article | Open AccessVolume 1 | Issue 3 |\u00a0https:\/\/doi.org\/10.15228\/2011.v01.i03.p04 Evaluation of Drug Induced Neuronal Damage in Rats R. Najam Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan S. Naeem Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan F. Aleem Department of Pharmacology, Faculty of Pharmacy, University of Karachi, [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2169","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Evaluation of Drug Induced Neuronal Damage in Rats - Pakistan Journal of Chemistry<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2011\/09\/10\/pjc-2011\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Evaluation of Drug Induced Neuronal Damage in Rats - Pakistan Journal of Chemistry\" \/>\n<meta property=\"og:description\" content=\"Research Article | Open AccessVolume 1 | Issue 3 |\u00a0https:\/\/doi.org\/10.15228\/2011.v01.i03.p04 Evaluation of Drug Induced Neuronal Damage in Rats R. 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