{"id":2066,"date":"2011-04-10T10:17:00","date_gmt":"2011-04-10T10:17:00","guid":{"rendered":"https:\/\/chempublishers.com\/pjc\/?p=2066"},"modified":"2025-03-20T14:55:22","modified_gmt":"2025-03-20T14:55:22","slug":"pjc-1011","status":"publish","type":"post","link":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2011\/04\/10\/pjc-1011\/","title":{"rendered":"Comparative Study On the Effect of Zopiclone and Flurazepam"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2066\" class=\"elementor elementor-2066\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-16dddf1 e-flex e-con-boxed e-con e-parent\" data-id=\"16dddf1\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-799adbc e-con-full e-flex e-con e-child\" data-id=\"799adbc\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-739ca35 elementor-widget elementor-widget-text-editor\" data-id=\"739ca35\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<table border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\"><tbody><tr><td><div><strong>Research Article | Open Access<\/strong><\/div><div class=\"item doi\"><span class=\"value\">Volume 1 | Issue 2 |\u00a0<a href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2024\/12\/168_1.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.15228\/2011.v01.i02.p02<\/a><\/span><\/div><\/td><\/tr><\/tbody><\/table><article class=\"obj_article_details\"><h4 class=\"page_title\">Comparative Study On the Effect of Zopiclone and Flurazepam<\/h4><div class=\"row\"><div class=\"main_entry\"><p><span class=\"name\">R. Najam<\/span><\/p><p>Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Pakistan<\/p><p><span class=\"name\">A. Nasir<\/span><\/p><p>Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Pakistan<\/p><p><span class=\"name\">S.S. Khan<\/span><\/p><p>Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Pakistan<\/p><table border=\"0\" width=\"93%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\"><tbody><tr><td align=\"center\" valign=\"top\"><strong>Received<\/strong><br \/>10 Mar, 2011<\/td><td align=\"center\" valign=\"top\"><strong>Accepted<\/strong><br \/>10 Jun, 2011<\/td><td align=\"center\" valign=\"top\"><strong>Published<\/strong><br \/>10 Dec, 2011<\/td><\/tr><\/tbody><\/table><div class=\"item abstract\"><p class=\"ql-align-justify\">Anxiety disorders are among most frequent mental disorders encountered by Clinicians. Untreated anxiety may result in increase health care utilization, morbidity, mortality and poorer quality of life. Individual with GAD, social phobias and panic disorder show less satisfaction with their quality of life. Basolateral amygdale has been implicated in anxiety generations. Mutations in Sk3 (calcium channel) are suspected to be underlying cause of severe neurological disorder including anxiety. Therapeutic effects of benzodiazepine are usually or often sustained over months or years, with the need for increased dosage in the treatment of GAD and panic disorders. Flurazepam is a hypnotic agent useful for the treatment of insomnia characterized by frequent nocturnal awakening and other insomnia symptoms such as trouble falling or staying sleep. It acts on BZ1 and BZ2 receptor sites. The mechanism of action of zopiclone is similar to benzodiazepines, but it wines more selectively to BZ1 receptor with similar effects on locomotor activity and on dopamine and serotonin turnover. Zopiclone although molecularly different from benzodiazepines, shares an almost identical pharmacological profile as benzodiazepines including anxiolytic properties. The present study is designed to assess two drugs of different classes that act through same receptor against control for their effects on some of the behavioral activities. Results indicated that zopiclone produced reduction in anxiety more than flurazepam.<\/p><\/div><div class=\"item abstract\"><div><h3 class=\"label\">How to Cite this paper?<\/h3><div class=\"csl-entry\"><p><strong>APA-7 Style<\/strong><br \/>Najam, R., Nasir, A., Khan, S.S. (2011). Comparative Study On the Effect of Zopiclone and Flurazepam.\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2011.v01.i02.p02\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>, 1(2), 60-64<\/a>. https:\/\/doi.org\/10.15228\/2011.v01.i02.p02<\/p><p><strong>ACS Style<\/strong><br \/>Najam, R.; Nasir, A.; Khan, S.S. Comparative Study On the Effect of Zopiclone and Flurazepam.\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2011.v01.i02.p02\" target=\"_blank\" rel=\"noopener\"><em>Pak. J. Chem.<\/em>\u00a02011, 1, 60-64<\/a>. https:\/\/doi.org\/10.15228\/2011.v01.i02.p02<\/p><p><strong>AMA Style<\/strong><br \/>Najam R, Nasir A, Khan SS. Comparative Study On the Effect of Zopiclone and Flurazepam.\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2011.v01.i02.p02\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>. 2011; 1(2): 60-64<\/a>. https:\/\/doi.org\/10.15228\/2011.v01.i02.p02<\/p><p><strong>Chicago\/Turabian Style<\/strong><br \/>Najam, R., A. Nasir, and S. S. Khan. 2011. &#8220;Comparative Study On the Effect of Zopiclone and Flurazepam&#8221;\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2011.v01.i02.p02\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>\u00a01, no. 2: 60-64<\/a>. https:\/\/doi.org\/10.15228\/2011.v01.i02.p02<\/p><\/div><\/div><\/div><div class=\"item copyright\"><p><a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\"><img decoding=\"async\" src=\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\" alt=\"Creative Commons License\" \/><\/a><\/p><p>This work is licensed under a\u00a0<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">Creative Commons Attribution 4.0 International License<\/a>.<\/p><\/div><\/div><\/div><\/article>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3e1ce0a e-con-full e-flex e-con e-child\" data-id=\"3e1ce0a\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Research Article | Open AccessVolume 1 | Issue 2 |\u00a0https:\/\/doi.org\/10.15228\/2011.v01.i02.p02 Comparative Study On the Effect of Zopiclone and Flurazepam R. Najam Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Pakistan A. Nasir Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Pakistan S.S. Khan Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Pakistan [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2066","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Comparative Study On the Effect of Zopiclone and Flurazepam - Pakistan Journal of Chemistry<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2011\/04\/10\/pjc-1011\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Comparative Study On the Effect of Zopiclone and Flurazepam - Pakistan Journal of Chemistry\" \/>\n<meta property=\"og:description\" content=\"Research Article | Open AccessVolume 1 | Issue 2 |\u00a0https:\/\/doi.org\/10.15228\/2011.v01.i02.p02 Comparative Study On the Effect of Zopiclone and Flurazepam R. Najam Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Pakistan A. Nasir Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Pakistan S.S. 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