{"id":2003,"date":"2011-03-24T08:34:00","date_gmt":"2011-03-24T08:34:00","guid":{"rendered":"https:\/\/chempublishers.com\/pjc\/?p=2003"},"modified":"2025-11-10T15:27:50","modified_gmt":"2025-11-10T15:27:50","slug":"pjc-0611","status":"publish","type":"post","link":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2011\/03\/24\/pjc-0611\/","title":{"rendered":"Evaluation of Herbal Drug for Hypoglycemic Activity in Normal, Hyperglycemic and Alloxan-Induced Diabetic Rabbits"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2003\" class=\"elementor elementor-2003\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1642bef4 e-flex e-con-boxed e-con e-parent\" data-id=\"1642bef4\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-472d3f98 elementor-widget elementor-widget-text-editor\" data-id=\"472d3f98\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\n<ul class=\"wp-block-list\">\n<li><\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7468c2a e-flex e-con-boxed e-con e-parent\" data-id=\"7468c2a\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2e2806b e-con-full e-flex e-con e-child\" data-id=\"2e2806b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aba2322 elementor-widget elementor-widget-text-editor\" data-id=\"aba2322\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<table border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\">\n<tbody>\n<tr>\n<td>\n<div><strong>Research Article | Open Access<\/strong><\/div>\n<div class=\"item doi\"><span class=\"value\">Volume 1 | Issue 1 |\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2011.v01.i01.p06\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.15228\/2011.v01.i01.p06<\/a><\/span><\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<article class=\"obj_article_details\">\n<h4 class=\"page_title\">Evaluation of Herbal Drug for Hypoglycemic Activity in Normal, Hyperglycemic and Alloxan-Induced Diabetic Rabbits<\/h4>\n<div class=\"row\">\n<div class=\"main_entry\"><span class=\"name\">N.M. Qadri<\/span>\n<p>PCSIR Laboratories Complex, Karachi-75280, Pakistan<\/p>\n<span class=\"name\">Zakir Ur Rehman<\/span>\n<p>PCSIR Laboratories Complex, Karachi-75280, Pakistan<\/p>\n<span class=\"name\">H.A. Rizvi<\/span>\n<p>Department of Biochemistry, Jinnah University for Women, 5-C, Nazimabad Karachi-74600, Pakistan<\/p>\n<br \/>\n<table border=\"0\" width=\"93%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\">\n<tbody>\n<tr>\n<td align=\"center\" valign=\"top\"><strong>Received<\/strong><br \/>06 Mar, 2011<\/td>\n<td align=\"center\" valign=\"top\"><strong>Accepted<\/strong><br \/>06 Jun, 2011<\/td>\n<td align=\"center\" valign=\"top\"><strong>Published<\/strong><br \/>06 Dec, 2011<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<br \/>\n<div class=\"item abstract\">\n<p align=\"justify\">\u00a0<\/p>\n<p class=\"ql-align-justify\">The herbal drug formulation (Diabrid) was evaluated for hypoglycemic activity in normal, glucose-fed hyperglycemic and alloxan-induced diabetic rabbits. Fasting blood glucose level was determined prior to the drug administration in each group. Blood sugar was also determined at various time intervals after oral drug administration and compared with the reference drug, Gliben clamide. The data was statistically analyzed. No significant hypoglycemic effect was produced by the herbal test drug in alloxaninduced diabetic rabbits. However, fasting blood glucose levels were significantly decreased in the normal animals within one hour after drug administration. The maximum hypoglycemic effect was noted within two hours. A significant hypoglycemic effect was observed in glucose-fed hyperglycemic rabbits. Diabrid at a dose of 1000 mg\/kg produced approximately the same effect as 3.3 mg\/kg Glibenclamide. The herbal drug did not produce any toxic effect at higher doses. The study suggests that Diabrid is a safe potential herbal medicine in the amelioration of hyperglycemia in Type-II diabetes. It has not shown any significant effect in insulin dependent diabetes mellitus (IDDM) animal model.<\/p>\n<p>\u00a0<\/p>\n<\/div>\n<div class=\"item abstract\">\n<div>\n<h3 class=\"label\">How to Cite this paper?<\/h3>\n<div class=\"csl-entry\">\n<p><br \/><strong>APA-7 Style<\/strong><br \/>Qadri, N.M., Rehman, Z.U., Rizvi, H.A. (2011). Evaluation of Herbal Drug for Hypoglycemic Activity in Normal, Hyperglycemic and Alloxan-Induced Diabetic Rabbits.\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2011.v01.i01.p06\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>, 1(1), 32-37<\/a>. https:\/\/doi.org\/10.15228\/2011.v01.i01.p06<br \/><br \/><strong>ACS Style<\/strong><br \/>Qadri, N.M.; Rehman, Z.U.; Rizvi, H.A. Evaluation of Herbal Drug for Hypoglycemic Activity in Normal, Hyperglycemic and Alloxan-Induced Diabetic Rabbits.\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2011.v01.i01.p06\" target=\"_blank\" rel=\"noopener\"><em>Pak. J. Chem.<\/em>\u00a02011, 1, 32-37<\/a>. https:\/\/doi.org\/10.15228\/2011.v01.i01.p06<br \/><br \/><strong>AMA Style<\/strong><br \/>Qadri NM, Rehman ZU, Rizvi HA. Evaluation of Herbal Drug for Hypoglycemic Activity in Normal, Hyperglycemic and Alloxan-Induced Diabetic Rabbits.\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2011.v01.i01.p06\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>. 2011; 1(1): 32-37<\/a>. https:\/\/doi.org\/10.15228\/2011.v01.i01.p06<br \/><br \/><strong>Chicago\/Turabian Style<\/strong><br \/>Qadri, N., M., Zakir Ur Rehman, and H. A. Rizvi. 2011. &#8220;Evaluation of Herbal Drug for Hypoglycemic Activity in Normal, Hyperglycemic and Alloxan-Induced Diabetic Rabbits&#8221;\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2011.v01.i01.p06\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>\u00a01, no. 1: 32-37<\/a>. https:\/\/doi.org\/10.15228\/2011.v01.i01.p06<\/p>\n<\/div>\n<p>\u00a0<\/p>\n<\/div>\n<\/div>\n<div class=\"item copyright\"><a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\"><img decoding=\"async\" src=\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\" alt=\"Creative Commons License\" \/><\/a>\n<p>This work is licensed under a\u00a0<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">Creative Commons Attribution 4.0 International License<\/a>.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/article>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b42033d e-con-full e-flex e-con e-child\" data-id=\"b42033d\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Research Article | Open Access Volume 1 | Issue 1 |\u00a0https:\/\/doi.org\/10.15228\/2011.v01.i01.p06 Evaluation of Herbal Drug for Hypoglycemic Activity in Normal, Hyperglycemic and Alloxan-Induced Diabetic Rabbits N.M. Qadri PCSIR Laboratories Complex, Karachi-75280, Pakistan Zakir Ur Rehman PCSIR Laboratories Complex, Karachi-75280, Pakistan H.A. Rizvi Department of Biochemistry, Jinnah University for Women, 5-C, Nazimabad Karachi-74600, Pakistan Received06 Mar, [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2003","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Evaluation of Herbal Drug for Hypoglycemic Activity in Normal, Hyperglycemic and Alloxan-Induced Diabetic Rabbits - Pakistan Journal of Chemistry<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2011\/03\/24\/pjc-0611\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Evaluation of Herbal Drug for Hypoglycemic Activity in Normal, Hyperglycemic and Alloxan-Induced Diabetic Rabbits - Pakistan Journal of Chemistry\" \/>\n<meta property=\"og:description\" content=\"Research Article | Open Access Volume 1 | Issue 1 |\u00a0https:\/\/doi.org\/10.15228\/2011.v01.i01.p06 Evaluation of Herbal Drug for Hypoglycemic Activity in Normal, Hyperglycemic and Alloxan-Induced Diabetic Rabbits N.M. Qadri PCSIR Laboratories Complex, Karachi-75280, Pakistan Zakir Ur Rehman PCSIR Laboratories Complex, Karachi-75280, Pakistan H.A. 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