{"id":1706,"date":"2013-12-29T23:25:00","date_gmt":"2013-12-29T23:25:00","guid":{"rendered":"https:\/\/chempublishers.sourcingoutfit.com\/?p=1706"},"modified":"2025-02-02T18:12:04","modified_gmt":"2025-02-02T18:12:04","slug":"pjc-3013","status":"publish","type":"post","link":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2013\/12\/29\/pjc-3013\/","title":{"rendered":"Antitumor Activity of New Quinoxaline Analogues and Its Complexes"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"1706\" class=\"elementor elementor-1706\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-09de316 e-flex e-con-boxed e-con e-parent\" data-id=\"09de316\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-fe01989 e-con-full e-flex e-con e-child\" data-id=\"fe01989\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a5610ca elementor-widget elementor-widget-text-editor\" data-id=\"a5610ca\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<table border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\"><tbody><tr><td><div><strong>Research Article | Open Access<\/strong><\/div><div class=\"item doi\"><span class=\"value\">Volume 3 | Issue 4 | Paper 06 |\u00a0 <a href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2025\/01\/PJC-v03.i04.p06.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.15228\/2013.v03.i04.p06<\/a><\/span><\/div><\/td><\/tr><\/tbody><\/table><article class=\"obj_article_details\"><h1 class=\"page_title\">Antitumor Activity of New Quinoxaline Analogues and Its Complexes<\/h1><div class=\"row\"><h4 class=\"main_entry\"><span class=\"name\">A.A. Ismaeel<\/span><\/h4><p>College of Education for Pure Science Ibn Al-Haitham, Department of Chemistry, University of Baghdad, Iraq<\/p><h4 class=\"main_entry\"><span class=\"name\">N.F. Yousif<\/span><\/h4><p>College of Education for Pure Science Ibn Al-Haitham, Department of Chemistry, University of Baghdad, Iraq<\/p><h4 class=\"main_entry\"><span class=\"name\">K.F. Ali<\/span><\/h4><p>College of Education for Pure Science Ibn Al-Haitham, Department of Chemistry, University of Baghdad, Iraq<\/p><h4 class=\"main_entry\"><span class=\"name\">F.H. Mousa<\/span><\/h4><p>College of Education for Pure Science Ibn Al-Haitham, Department of Chemistry, University of Baghdad, Iraq<\/p><table border=\"0\" width=\"93%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\"><tbody><tr><td align=\"center\" valign=\"top\"><strong>Received<\/strong><br \/>01 May, 2013<\/td><td align=\"center\" valign=\"top\"><strong>Accepted<\/strong><br \/>01 Nov, 2013<\/td><td align=\"center\" valign=\"top\"><strong>Published<\/strong><br \/>04 Dec, 2013<\/td><\/tr><\/tbody><\/table><div class=\"item abstract\"><p align=\"justify\">ABSTRACT:<\/p><p class=\"ql-align-justify\">This study shows synthesis of a new quinoxaline derivatives (LH) and preparation of copper (Cu-LH) and cobalt (Co-LH) complexes and studying the effect of these compounds on the activity of lactate dehydrogenase (LDH) a primary enzyme to the process of anaerobic glycolysis which is the source of energy in tumor cell. This study included of 40 women with recently diagnosed of malignancies Breast cancer; (20) subject women in stage I&amp;(20)subject women in stage II who were admitted to Medical City Hospital with age ranged (37-45) years and 30 apparently healthy woman matched for age served as controls. Serum LDH activity was assayed on the time of the diagnosis in all cases and after addition of different concentrations (10<sup>-1<\/sup>, 10<sup>-2<\/sup>, 10<sup>-3<\/sup>\u00a0) of quinoxalin derivatives and transition metals complexes in vitro. The results revealed an inhibitory effect of LH and its complexes with Cu and Co in all concentrations used in this study on LDH activity. The inhibition percent\u2019s increased with increase concentration for LH and its complexes. Also the results reveal that the inhibitory effect of LH in all concentrations used were more than inhibitory effect of its complexes. Moreover the inhibitory effect of LH-Co complex was more than inhibitory effect of LH-Cu complex in all concentrations used. The inhibition ability of quinoxaline derivative and its complexes on the enzyme lactate dehydrogenase leads to the fact that these compounds can be characterized as an active anti \u2013cancer substances for one of the metabolic enzymes necessary to feed the cancer cells.<\/p><\/div><div class=\"item abstract\"><div><h3 class=\"label\">How to Cite this paper?<\/h3><div class=\"csl-entry\"><p><strong>APA-7 Style<\/strong><br \/>Ismaeel, A.A., Yousif, N.F., Ali, K.F., Mousa, F.H. (2013). Antitumor Activity of New Quinoxaline Analogues and Its Complexes.\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2013.v03.i04.p06\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>, 3(4), 177-181<\/a>. https:\/\/doi.org\/10.15228\/2013.v03.i04.p06<\/p><p><strong>ACS Style<\/strong><br \/>Ismaeel, A.A.; Yousif, N.F.; Ali, K.F.; Mousa, F.H. Antitumor Activity of New Quinoxaline Analogues and Its Complexes.\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2013.v03.i04.p06\" target=\"_blank\" rel=\"noopener\"><em>Pak. J. Chem.<\/em>\u00a02013, 3, 177-181<\/a>. https:\/\/doi.org\/10.15228\/2013.v03.i04.p06<\/p><p><strong>AMA Style<\/strong><br \/>Ismaeel AA, Yousif NF, Ali KF, Mousa FH. Antitumor Activity of New Quinoxaline Analogues and Its Complexes.\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2013.v03.i04.p06\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>. 2013; 3(4): 177-181<\/a>. https:\/\/doi.org\/10.15228\/2013.v03.i04.p06<\/p><p><strong>Chicago\/Turabian Style<\/strong><br \/>Ismaeel, A., A., N. F. Yousif, K. F. Ali, and F. H. Mousa. 2013. &#8220;Antitumor Activity of New Quinoxaline Analogues and Its Complexes&#8221;\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2013.v03.i04.p06\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>\u00a03, no. 4: 177-181<\/a>. https:\/\/doi.org\/10.15228\/2013.v03.i04.p06<\/p><\/div><\/div><\/div><div class=\"item copyright\"><p><a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\"><img decoding=\"async\" src=\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\" alt=\"Creative Commons License\" \/><\/a><\/p><p>This work is licensed under a\u00a0<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">Creative Commons Attribution 4.0 International License<\/a>.<\/p><\/div><\/div><\/article>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2d2025b e-con-full e-flex e-con e-child\" data-id=\"2d2025b\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Research Article | Open AccessVolume 3 | Issue 4 | Paper 06 |\u00a0 https:\/\/doi.org\/10.15228\/2013.v03.i04.p06 Antitumor Activity of New Quinoxaline Analogues and Its Complexes A.A. Ismaeel College of Education for Pure Science Ibn Al-Haitham, Department of Chemistry, University of Baghdad, Iraq N.F. Yousif College of Education for Pure Science Ibn Al-Haitham, Department of Chemistry, University of [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1706","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Antitumor Activity of New Quinoxaline Analogues and Its Complexes - Pakistan Journal of Chemistry<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2013\/12\/29\/pjc-3013\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Antitumor Activity of New Quinoxaline Analogues and Its Complexes - Pakistan Journal of Chemistry\" \/>\n<meta property=\"og:description\" content=\"Research Article | Open AccessVolume 3 | Issue 4 | Paper 06 |\u00a0 https:\/\/doi.org\/10.15228\/2013.v03.i04.p06 Antitumor Activity of New Quinoxaline Analogues and Its Complexes A.A. 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