{"id":1660,"date":"2013-12-02T22:04:00","date_gmt":"2013-12-02T22:04:00","guid":{"rendered":"https:\/\/chempublishers.sourcingoutfit.com\/?p=1660"},"modified":"2025-02-02T18:03:22","modified_gmt":"2025-02-02T18:03:22","slug":"pjc-2513","status":"publish","type":"post","link":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2013\/12\/02\/pjc-2513\/","title":{"rendered":"Synthesis and Antibacterial Activity ofN-(un)substituted-N-((3,4 Methylenedioxyphenyl)methyl) arylsulfonamides"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"1660\" class=\"elementor elementor-1660\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a9a1e92 e-flex e-con-boxed e-con e-parent\" data-id=\"a9a1e92\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-a617994 e-con-full e-flex e-con e-child\" data-id=\"a617994\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8de2efa elementor-widget elementor-widget-text-editor\" data-id=\"8de2efa\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<table border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\"><tbody><tr><td><div><strong>Research Article | Open Access<\/strong><\/div><div class=\"item doi\"><span class=\"value\">Volume 3 | Issue 4 | Paper 01 |\u00a0 <a href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2025\/01\/PJC-v03.i04.p02.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.15228\/2013.v03.i04.p01<\/a><\/span><\/div><\/td><\/tr><\/tbody><\/table><article class=\"obj_article_details\"><h1 class=\"page_title\">Synthesis and Antibacterial Activity of<i>N<\/i>-(un)substituted-<i>N<\/i>-((3,4 Methylenedioxyphenyl)methyl) arylsulfonamides<\/h1><div class=\"row\"><h4 class=\"main_entry\"><span class=\"name\">Aziz Ur Rehman<\/span><\/h4><p>Department of Chemistry, Government College University, Lahore-54000, Pakistan<\/p><h4 class=\"main_entry\"><span class=\"name\">A. Siddiqa<\/span><\/h4><p>Department of Chemistry, Government College University, Lahore-54000, Pakistan<\/p><h4 class=\"main_entry\"><span class=\"name\">M.A. Abbasi<\/span><\/h4><p>Department of Chemistry, Government College University, Lahore-54000, Pakistan<\/p><h4 class=\"main_entry\"><span class=\"name\">S. Rasool<\/span><\/h4><p>Department of Chemistry, Government College University, Lahore-54000, Pakistan<\/p><h4 class=\"main_entry\"><span class=\"name\">K. Nafeesa<\/span><\/h4><p>Department of Chemistry, Government College University, Lahore-54000, Pakistan<\/p><h4 class=\"main_entry\"><span class=\"name\">S. Gul<\/span><\/h4><p>Department of Chemistry, Government College University, Lahore-54000, Pakistan<\/p><h4 class=\"main_entry\"><span class=\"name\">I. Ahmed<\/span><\/h4><p>Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan<\/p><h4 class=\"main_entry\"><span class=\"name\">S. Afzal<\/span><\/h4><p>Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan<\/p><table border=\"0\" width=\"93%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\"><tbody><tr><td align=\"center\" valign=\"top\"><strong>Received<\/strong><br \/>29 Apr, 2013<\/td><td align=\"center\" valign=\"top\"><strong>Accepted<\/strong><br \/>30 Oct, 2013<\/td><td align=\"center\" valign=\"top\"><strong>Published<\/strong><br \/>02 Dec, 2013<\/td><\/tr><\/tbody><\/table><div class=\"item abstract\"><p align=\"justify\">ABSTRACT:<\/p><p class=\"ql-align-justify\">Sulfonamides belong to an active group with biological activities and these activities can be enhanced by introducing heterocyclic moiety.\u00a0<em>N<\/em>-((3,4-methylenedioxyphenyl)methyl) arylsulfonamides (3a-f) were synthesized by gearing up (3,4- methylenedioxyphenyl)methyl amine (1) and arylsulfonyl chlorides (2a-f) in a weak basic aqueous medium. The target molecules, 6a-f and 7a-f were yielded by the reaction of 3a-f with ethyl iodide (4) and 4-flourobenzyl chloride (5) respectively in a weak basic aprotic polar medium. Structural analysis of the synthesized molecules was processed through the spectral data of IR,\u00a0<sup>1<\/sup>HNMR,\u00a0<sup>13<\/sup>C-NMR and EIMS. All the synthesized molecules were evaluated for the antibacterial activity and remained moderately better inhibitors.<\/p><\/div><div class=\"item abstract\"><div><h3 class=\"label\">How to Cite this paper?<\/h3><div class=\"csl-entry\"><p><strong>APA-7 Style<\/strong><br \/>Rehman, A.U., Siddiqa, A., Abbasi, M.A., Rasool, S., Nafeesa, K., Gul, S., Ahmed, I., Afzal, S. (2013). Synthesis and Antibacterial Activity of<i>N<\/i>-(un)substituted-<i>N<\/i>-((3,4 Methylenedioxyphenyl)methyl) arylsulfonamides<br \/>.\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2013.v03.i04.p01\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>, 3(4), 142-149<\/a>. https:\/\/doi.org\/10.15228\/2013.v03.i04.p01<\/p><p><strong>ACS Style<\/strong><br \/>Rehman, A.U.; Siddiqa, A.; Abbasi, M.A.; Rasool, S.; Nafeesa, K.; Gul, S.; Ahmed, I.; Afzal, S. Synthesis and Antibacterial Activity of<i>N<\/i>-(un)substituted-<i>N<\/i>-((3,4 Methylenedioxyphenyl)methyl) arylsulfonamides<br \/>.\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2013.v03.i04.p01\" target=\"_blank\" rel=\"noopener\"><em>Pak. J. Chem.<\/em>\u00a02013, 3, 142-149<\/a>. https:\/\/doi.org\/10.15228\/2013.v03.i04.p01<\/p><p><strong>AMA Style<\/strong><br \/>Rehman AU, Siddiqa A, Abbasi MA, Rasool S, Nafeesa K, Gul S, Ahmed I, Afzal S. Synthesis and Antibacterial Activity of<i>N<\/i>-(un)substituted-<i>N<\/i>-((3,4 Methylenedioxyphenyl)methyl) arylsulfonamides<br \/>.\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2013.v03.i04.p01\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>. 2013; 3(4): 142-149<\/a>. https:\/\/doi.org\/10.15228\/2013.v03.i04.p01<\/p><p><strong>Chicago\/Turabian Style<\/strong><br \/>Rehman, Aziz, Ur, A. Siddiqa, M. A. Abbasi, S. Rasool, K. Nafeesa, S. Gul, I. Ahmed, and S. Afzal. 2013. &#8220;Synthesis and Antibacterial Activity of<i>N<\/i>-(un)substituted-<i>N<\/i>-((3,4 Methylenedioxyphenyl)methyl) arylsulfonamides<br \/>&#8221;\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2013.v03.i04.p01\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>\u00a03, no. 4: 142-149<\/a>. https:\/\/doi.org\/10.15228\/2013.v03.i04.p01<\/p><\/div><\/div><\/div><div class=\"item copyright\"><p><a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\"><img decoding=\"async\" src=\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\" alt=\"Creative Commons License\" \/><\/a><\/p><p>This work is licensed under a\u00a0<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">Creative Commons Attribution 4.0 International License<\/a>.<\/p><\/div><\/div><\/article>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9c18232 e-con-full e-flex e-con e-child\" data-id=\"9c18232\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Research Article | Open AccessVolume 3 | Issue 4 | Paper 01 |\u00a0 https:\/\/doi.org\/10.15228\/2013.v03.i04.p01 Synthesis and Antibacterial Activity ofN-(un)substituted-N-((3,4 Methylenedioxyphenyl)methyl) arylsulfonamides Aziz Ur Rehman Department of Chemistry, Government College University, Lahore-54000, Pakistan A. Siddiqa Department of Chemistry, Government College University, Lahore-54000, Pakistan M.A. Abbasi Department of Chemistry, Government College University, Lahore-54000, Pakistan S. Rasool Department [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1660","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Synthesis and Antibacterial Activity ofN-(un)substituted-N-((3,4 Methylenedioxyphenyl)methyl) arylsulfonamides - Pakistan Journal of Chemistry<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2013\/12\/02\/pjc-2513\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Synthesis and Antibacterial Activity ofN-(un)substituted-N-((3,4 Methylenedioxyphenyl)methyl) arylsulfonamides - Pakistan Journal of Chemistry\" \/>\n<meta property=\"og:description\" content=\"Research Article | Open AccessVolume 3 | Issue 4 | Paper 01 |\u00a0 https:\/\/doi.org\/10.15228\/2013.v03.i04.p01 Synthesis and Antibacterial Activity ofN-(un)substituted-N-((3,4 Methylenedioxyphenyl)methyl) arylsulfonamides Aziz Ur Rehman Department of Chemistry, Government College University, Lahore-54000, Pakistan A. 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