{"id":1642,"date":"2013-09-16T20:31:00","date_gmt":"2013-09-16T20:31:00","guid":{"rendered":"https:\/\/chempublishers.sourcingoutfit.com\/?p=1642"},"modified":"2025-11-11T15:21:19","modified_gmt":"2025-11-11T15:21:19","slug":"pjc-2213","status":"publish","type":"post","link":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2013\/09\/16\/pjc-2213\/","title":{"rendered":"Nitrated and Brominated Narcotine and its Cleaved Adduct as Butyrylcholinesterase Inhibitors"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"1642\" class=\"elementor elementor-1642\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5b76c98 e-flex e-con-boxed e-con e-parent\" data-id=\"5b76c98\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-f0caf7f e-con-full e-flex e-con e-child\" data-id=\"f0caf7f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-acb5cd6 elementor-widget elementor-widget-text-editor\" data-id=\"acb5cd6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<table border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\"><tbody><tr><td><div><strong>Research Article | Open Access<\/strong><\/div><div class=\"item doi\"><span class=\"value\">Volume 3 | Issue 3 | Paper 06 |\u00a0 <a href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2025\/01\/PJC-v03.i03.p06.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.15228\/2013.v03.i03.p06<\/a><\/span><\/div><\/td><\/tr><\/tbody><\/table><article class=\"obj_article_details\"><h4 class=\"page_title\">Nitrated and Brominated Narcotine and its Cleaved Adduct as Butyrylcholinesterase Inhibitors<\/h4><div class=\"row\"><h4 class=\"main_entry\"><span class=\"name\">M.A. Abbasi<\/span><\/h4><p>Department of Chemistry, Government College University, Lahore-54000, Pakistan<\/p><h4 class=\"main_entry\"><span class=\"name\">Aziz Ur Rehman<\/span><\/h4><p>Department of Chemistry, Government College University, Lahore-54000, Pakistan<\/p><h4 class=\"main_entry\"><span class=\"name\">M. Z. Qureshi<\/span><\/h4><p>Department of Chemistry, Government College University, Lahore-54000, Pakistan<\/p><h4 class=\"main_entry\"><span class=\"name\">M.S. Shahid<\/span><\/h4><p>Department of Chemistry, Government College University, Lahore-54000, Pakistan<\/p><h4 class=\"main_entry\"><span class=\"name\">S. Rasool<\/span><\/h4><p>Department of Chemistry, Government College University, Lahore-54000, Pakistan<\/p><h4 class=\"main_entry\"><span class=\"name\">M. Ashraf<\/span><\/h4><p>Department of Biochemistry and Biotechnology; Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan<\/p><table border=\"0\" width=\"93%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\"><tbody><tr><td align=\"center\" valign=\"top\"><strong>Received<\/strong><br \/>25 Apr, 2013<\/td><td align=\"center\" valign=\"top\"><strong>Accepted<\/strong><br \/>26 Oct, 2013<\/td><td align=\"center\" valign=\"top\"><strong>Published<\/strong><br \/>28 Nov, 2013<\/td><\/tr><\/tbody><\/table><div class=\"item abstract\"><p align=\"justify\">ABSTRACT:<\/p><p class=\"ql-align-justify\">Narcotine is a very antitussive agent and its modification may lead to some more biological activities. In this presented paper, narcotine (1) was first subjected to nitration and bromination to yield nitrated narcotine (2) and brominated narcotine (3). It was further made to react with phenylchloroformate (6) to give a cleaved addition product 4. This adduct 4 was further nitrated and brominated to yield substituted derivatives 5 and 6, respectively. The structure elucidation of the synthesized compounds was processed via IR, EI-MS and\u00a0<sup>1<\/sup>H-NMR spectra. These were also screened against butyrylcholinesterase enzyme and were found to the moderate inhibitors of butyrylcholinesterase except nitrated product, 2, of narcotine (1).<\/p><\/div><div class=\"item abstract\"><div><h3 class=\"label\">How to Cite this paper?<\/h3><div class=\"csl-entry\"><p><strong>APA-7 Style<\/strong><br \/>Abbasi, M.A., Rehman, A.U., Qureshi, M.Z., Shahid, M.S., Rasool, S., Ashraf, M. (2013). Nitrated and Brominated Narcotine and its Cleaved Adduct as Butyrylcholinesterase Inhibitors<br \/>.\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2013.v03.i03.p06\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>, 3(3), 129-133<\/a>. https:\/\/doi.org\/10.15228\/2013.v03.i03.p06<\/p><p><strong>ACS Style<\/strong><br \/>Abbasi, M.A.; Rehman, A.U.; Qureshi, M.Z.; Shahid, M.S.; Rasool, S.; Ashraf, M. Nitrated and Brominated Narcotine and its Cleaved Adduct as Butyrylcholinesterase Inhibitors<br \/>.\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2013.v03.i03.p06\" target=\"_blank\" rel=\"noopener\"><em>Pak. J. Chem.<\/em>\u00a02013, 3, 129-133<\/a>. https:\/\/doi.org\/10.15228\/2013.v03.i03.p06<\/p><p><strong>AMA Style<\/strong><br \/>Abbasi MA, Rehman AU, Qureshi MZ, Shahid MS, Rasool S, Ashraf M. Nitrated and Brominated Narcotine and its Cleaved Adduct as Butyrylcholinesterase Inhibitors<br \/>.\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2013.v03.i03.p06\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>. 2013; 3(3): 129-133<\/a>. https:\/\/doi.org\/10.15228\/2013.v03.i03.p06<\/p><p><strong>Chicago\/Turabian Style<\/strong><br \/>Abbasi, M., A., Aziz Ur Rehman, M. Z. Qureshi, M. S. Shahid, S. Rasool, and M. Ashraf. 2013. &#8220;Nitrated and Brominated Narcotine and its Cleaved Adduct as Butyrylcholinesterase Inhibitors<br \/>&#8221;\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2013.v03.i03.p06\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>\u00a03, no. 3: 129-133<\/a>. https:\/\/doi.org\/10.15228\/2013.v03.i03.p06<\/p><\/div><\/div><\/div><div class=\"item copyright\"><p><a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\"><img decoding=\"async\" src=\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\" alt=\"Creative Commons License\" \/><\/a><\/p><p>This work is licensed under a\u00a0<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">Creative Commons Attribution 4.0 International License<\/a>.<\/p><\/div><\/div><\/article>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cd7e70c e-con-full e-flex e-con e-child\" data-id=\"cd7e70c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Research Article | Open AccessVolume 3 | Issue 3 | Paper 06 |\u00a0 https:\/\/doi.org\/10.15228\/2013.v03.i03.p06 Nitrated and Brominated Narcotine and its Cleaved Adduct as Butyrylcholinesterase Inhibitors M.A. Abbasi Department of Chemistry, Government College University, Lahore-54000, Pakistan Aziz Ur Rehman Department of Chemistry, Government College University, Lahore-54000, Pakistan M. Z. Qureshi Department of Chemistry, Government College University, [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1642","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Nitrated and Brominated Narcotine and its Cleaved Adduct as Butyrylcholinesterase Inhibitors - Pakistan Journal of Chemistry<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2013\/09\/16\/pjc-2213\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nitrated and Brominated Narcotine and its Cleaved Adduct as Butyrylcholinesterase Inhibitors - Pakistan Journal of Chemistry\" \/>\n<meta property=\"og:description\" content=\"Research Article | Open AccessVolume 3 | Issue 3 | Paper 06 |\u00a0 https:\/\/doi.org\/10.15228\/2013.v03.i03.p06 Nitrated and Brominated Narcotine and its Cleaved Adduct as Butyrylcholinesterase Inhibitors M.A. Abbasi Department of Chemistry, Government College University, Lahore-54000, Pakistan Aziz Ur Rehman Department of Chemistry, Government College University, Lahore-54000, Pakistan M. 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