{"id":1329,"date":"2012-06-20T20:45:00","date_gmt":"2012-06-20T20:45:00","guid":{"rendered":"https:\/\/chempublishers.sourcingoutfit.com\/?p=1329"},"modified":"2025-01-20T13:50:11","modified_gmt":"2025-01-20T13:50:11","slug":"pjc-1512","status":"publish","type":"post","link":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2012\/06\/20\/pjc-1512\/","title":{"rendered":"Complexation, Stability and Stoichiometry of Iron (III) with Salbutamol (Active ingredient of Asthma drug Ventolin\u00ae)"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"1329\" class=\"elementor elementor-1329\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-601d480 e-flex e-con-boxed e-con e-parent\" data-id=\"601d480\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-661ddc5 e-con-full e-flex e-con e-child\" data-id=\"661ddc5\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e9a2548 elementor-widget elementor-widget-text-editor\" data-id=\"e9a2548\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<table border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\"><tbody><tr><td><div><strong>Research Article | Open Access<\/strong><\/div><div class=\"item doi\"><span class=\"value\">Volume 2 | Issue 2 | Paper 07 | <a href=\"https:\/\/chempublishers.com\/pjc\/wp-content\/uploads\/sites\/2\/2024\/12\/141_1.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.15228\/2012.v02.i02.p07<\/a><\/span><\/div><\/td><\/tr><\/tbody><\/table><article class=\"obj_article_details\"><h1 class=\"page_title\">Complexation, Stability and Stoichiometry of Iron (III) with Salbutamol (Active ingredient of Asthma drug Ventolin<sup>\u00ae<\/sup>)<\/h1><div class=\"row\"><h4 class=\"main_entry\"><span class=\"name\">N. Fatima<\/span><\/h4><p>Department of Chemistry, University of Karachi, Karachi &#8211; Pakistan<\/p><table border=\"0\" width=\"93%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\"><tbody><tr><td align=\"center\" valign=\"top\"><strong>Received<\/strong><br \/>14 Mar, 2012<\/td><td align=\"center\" valign=\"top\"><strong>Accepted<\/strong><br \/>14 Jun, 2012<\/td><td align=\"center\" valign=\"top\"><strong>Published<\/strong><br \/>14 Dec, 2012<\/td><\/tr><\/tbody><\/table><div class=\"item abstract\"><p align=\"justify\">ABSTRACT:<\/p><p class=\"ql-align-justify\">Asthma is a wide speared disease all over the world. In this disease breathing is not smooth due to contraction of bronchitis. Ventolin is an effective drug for this purpose and is widely used. Its active ingredient is Salbutamol Sulphate, which is bronchodilator. Due to oxygen and nitrogen donor sites of Salbutamol (Fig I), it has been assumed that it may interact with metals present in the biological system, and therefore disturb the metals metabolism and imbalance the equilibrium. On the other hand two third of the body\u2019s iron is found in hemoglobin which is an oxygen storage protein. Therefore may iron is chelated by the Salbutamol ion in the stomach. The chelation of iron by salbutamol, stability of the complex and Stoichiometry at acidic pH of the said complex is investigated implied Spectrophotometric technique. Salbutamol formed highly colored complex with iron having maximum absorbance at 550nm. A 1:3 complex formation in buffered and non buffered solutions at 30\u00b0C was found using mole ratio and slope ratio methods. Molar extinction coefficients were determined by calibration curve method and was found very high in non buffered solution comparative to buffered solutions. Stability constant of ML1 is found 6.3635, ML<sub>2<\/sub>\u00a0is 11.919 and ML3 is 16.858 in non buffered solution. Closer ln values were found in buffer of pH 3.0 and 3.5.<\/p><\/div><div class=\"item abstract\"><div><h3 class=\"label\">How to Cite this paper?<\/h3><div class=\"csl-entry\"><p><strong>APA-7 Style<\/strong><br \/>Fatima, N. (2012). Complexation, Stability and Stoichiometry of Iron (III) with Salbutamol (Active ingredient of Asthma drug Ventolin<sup>\u00ae<\/sup>).\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2012.v02.i02.p07\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>, 2(2), 91-98<\/a>. https:\/\/doi.org\/10.15228\/2012.v02.i02.p07<\/p><p><strong>ACS Style<\/strong><br \/>Fatima, N. Complexation, Stability and Stoichiometry of Iron (III) with Salbutamol (Active ingredient of Asthma drug Ventolin<sup>\u00ae<\/sup>).\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2012.v02.i02.p07\" target=\"_blank\" rel=\"noopener\"><em>Pak. J. Chem.<\/em>\u00a02012, 2, 91-98<\/a>. https:\/\/doi.org\/10.15228\/2012.v02.i02.p07<\/p><p><strong>AMA Style<\/strong><br \/>Fatima N. Complexation, Stability and Stoichiometry of Iron (III) with Salbutamol (Active ingredient of Asthma drug Ventolin<sup>\u00ae<\/sup>).\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2012.v02.i02.p07\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>. 2012; 2(2): 91-98<\/a>. https:\/\/doi.org\/10.15228\/2012.v02.i02.p07<\/p><p><strong>Chicago\/Turabian Style<\/strong><br \/>Fatima, N.. 2012. &#8220;Complexation, Stability and Stoichiometry of Iron (III) with Salbutamol (Active ingredient of Asthma drug Ventolin<sup>\u00ae<\/sup>)&#8221;\u00a0<a href=\"https:\/\/doi.org\/10.15228\/2012.v02.i02.p07\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>\u00a02, no. 2: 91-98<\/a>. https:\/\/doi.org\/10.15228\/2012.v02.i02.p07<\/p><\/div><\/div><\/div><div class=\"item copyright\"><p><a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\"><img decoding=\"async\" src=\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\" alt=\"Creative Commons License\" \/><\/a><\/p><p>This work is licensed under a\u00a0<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">Creative Commons Attribution 4.0 International License<\/a>.<\/p><\/div><\/div><\/article>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-84ab75b e-con-full e-flex e-con e-child\" data-id=\"84ab75b\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Research Article | Open AccessVolume 2 | Issue 2 | Paper 07 | https:\/\/doi.org\/10.15228\/2012.v02.i02.p07 Complexation, Stability and Stoichiometry of Iron (III) with Salbutamol (Active ingredient of Asthma drug Ventolin\u00ae) N. Fatima Department of Chemistry, University of Karachi, Karachi &#8211; Pakistan Received14 Mar, 2012 Accepted14 Jun, 2012 Published14 Dec, 2012 ABSTRACT: Asthma is a wide speared [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1329","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Complexation, Stability and Stoichiometry of Iron (III) with Salbutamol (Active ingredient of Asthma drug Ventolin\u00ae) - Pakistan Journal of Chemistry<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2012\/06\/20\/pjc-1512\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Complexation, Stability and Stoichiometry of Iron (III) with Salbutamol (Active ingredient of Asthma drug Ventolin\u00ae) - Pakistan Journal of Chemistry\" \/>\n<meta property=\"og:description\" content=\"Research Article | Open AccessVolume 2 | Issue 2 | Paper 07 | https:\/\/doi.org\/10.15228\/2012.v02.i02.p07 Complexation, Stability and Stoichiometry of Iron (III) with Salbutamol (Active ingredient of Asthma drug Ventolin\u00ae) N. 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