{"id":1221,"date":"2012-03-05T18:13:00","date_gmt":"2012-03-05T18:13:00","guid":{"rendered":"https:\/\/chempublishers.sourcingoutfit.com\/?p=1221"},"modified":"2025-06-16T14:10:22","modified_gmt":"2025-06-16T14:10:22","slug":"pjc-0312","status":"publish","type":"post","link":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2012\/03\/05\/pjc-0312\/","title":{"rendered":"An Improved Synthesis And Biological Evaluation Of Some New 4,5-dihydro-pyrazole1-Carbaldehyde Derivatives"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"1221\" class=\"elementor elementor-1221\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fa790d9 e-flex e-con-boxed e-con e-parent\" data-id=\"fa790d9\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-a5aa2f8 e-con-full e-flex e-con e-child\" data-id=\"a5aa2f8\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0b0d610 elementor-widget elementor-widget-text-editor\" data-id=\"0b0d610\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<table border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\">\n<tbody>\n<tr>\n<td>\n<div><strong>Research Article | Open Access<\/strong><\/div>\n<div class=\"item doi\"><span class=\"value\">Volume 2 | Issue 1 | Paper 03 |&nbsp; <a href=\"https:\/\/chempublishers.com\/pjc\/wp-content\/uploads\/sites\/2\/2024\/12\/130.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.15228\/2012.v02.i01.p03<\/a><\/span><\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<article class=\"obj_article_details\">\n<h4>An Improved Synthesis And Biological Evaluation Of Some New 4,5-dihydro-pyrazole1-Carbaldehyde Derivatives<\/h4>\n<div class=\"row\">\n<h4 class=\"main_entry\"><span class=\"name\">Y.B. Vibhute<\/span><\/h4>\n<p>Organic Research Laboratory, P.G. Department of studies in Chemistry,<br>Yeshwant Mahavidyalaya Nanded &#8211; 431602 (M.S.) India<\/p>\n<h4 class=\"main_entry\"><span class=\"name\">S.B. Zangade<\/span><\/h4>\n<p>Organic Research Laboratory, P.G. Department of studies in Chemistry,<br>Yeshwant Mahavidyalaya Nanded &#8211; 431602 (M.S.) India<\/p>\n<h4 class=\"main_entry\"><span class=\"name\">A.T. Shinde<\/span><\/h4>\n<p>Organic Research Laboratory, P.G. Department of studies in Chemistry,<br>Yeshwant Mahavidyalaya Nanded &#8211; 431602 (M.S.) India<\/p>\n<h4 class=\"main_entry\"><span class=\"name\">A.Y. Vibhute<\/span><\/h4>\n<p>Organic Research Laboratory, P.G. Department of studies in Chemistry,<br>Yeshwant Mahavidyalaya Nanded &#8211; 431602 (M.S.) India<\/p>\n<h4 class=\"main_entry\">&nbsp;<\/h4>\n<table border=\"0\" width=\"93%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\">\n<tbody>\n<tr>\n<td align=\"center\" valign=\"top\"><strong>Received<\/strong><br>03 Mar, 2012<\/td>\n<td align=\"center\" valign=\"top\"><strong>Accepted<\/strong><br>03 Jun, 2012<\/td>\n<td align=\"center\" valign=\"top\"><strong>Published<\/strong><br>03 Dec, 2012<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div class=\"item abstract\">\n<h4 align=\"justify\">ABSTRACT:<\/h4>\n<p class=\"ql-align-justify\">An improved condensation of substituted chalcones 1a-g with hydrazine hydrate and formic acid in 2-methoxyethanol to afford new series of 4,5-dihydro-pyrazole-1-carbaldehyde derivatives 2a-g. Clean reaction conditions, simple workup procedure and short reaction time giving high yields of product are notable advantages of method. All newly synthesized compounds characterized by chemical test, spectral and elemental analysis. Further, all newly synthesized compounds were screened for their antimicrobial activity. Most of these title compounds exhibited potent activity.<\/p>\n<\/div>\n<div class=\"item abstract\">\n<div>\n<h3 class=\"label\">How to Cite this paper?<\/h3>\n<div class=\"csl-entry\">\n<p><strong>APA-7 Style<\/strong><br>Vibhute, Y.B., Zangade, S.B., Shinde, A.T., Vibhute, A.Y. (2012). An Improved Synthesis And Biological Evaluation Of Some New 4,5-dihydro-pyrazole1-Carbaldehyde Derivatives.&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2012.v02.i01.p03\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>, 2(1), 18-23<\/a>. https:\/\/doi.org\/10.15228\/2012.v02.i01.p03<\/p>\n<p><strong>ACS Style<\/strong><br>Vibhute, Y.B.; Zangade, S.B.; Shinde, A.T.; Vibhute, A.Y. An Improved Synthesis And Biological Evaluation Of Some New 4,5-dihydro-pyrazole1-Carbaldehyde Derivatives.&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2012.v02.i01.p03\" target=\"_blank\" rel=\"noopener\"><em>Pak. J. Chem.<\/em>&nbsp;2012, 2, 18-23<\/a>. https:\/\/doi.org\/10.15228\/2012.v02.i01.p03<\/p>\n<p><strong>AMA Style<\/strong><br>Vibhute YB, Zangade SB, Shinde AT, Vibhute AY. An Improved Synthesis And Biological Evaluation Of Some New 4,5-dihydro-pyrazole1-Carbaldehyde Derivatives.&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2012.v02.i01.p03\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>. 2012; 2(1): 18-23<\/a>. https:\/\/doi.org\/10.15228\/2012.v02.i01.p03<\/p>\n<p><strong>Chicago\/Turabian Style<\/strong><br>Vibhute, Y., B., S. B. Zangade, A. T. Shinde, and A. Y. Vibhute. 2012. &#8220;An Improved Synthesis And Biological Evaluation Of Some New 4,5-dihydro-pyrazole1-Carbaldehyde Derivatives&#8221;&nbsp;<a href=\"https:\/\/doi.org\/10.15228\/2012.v02.i01.p03\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>&nbsp;2, no. 1: 18-23<\/a>. https:\/\/doi.org\/10.15228\/2012.v02.i01.p03<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"item copyright\">\n<p><a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\"><img decoding=\"async\" src=\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\" alt=\"Creative Commons License\"><\/a><\/p>\n<p>This work is licensed under a&nbsp;<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">Creative Commons Attribution 4.0 International License<\/a>.<\/p>\n<\/div>\n<\/div>\n<\/article>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4b028c2 e-con-full e-flex e-con e-child\" data-id=\"4b028c2\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Research Article | Open Access Volume 2 | Issue 1 | Paper 03 |&nbsp; https:\/\/doi.org\/10.15228\/2012.v02.i01.p03 An Improved Synthesis And Biological Evaluation Of Some New 4,5-dihydro-pyrazole1-Carbaldehyde Derivatives Y.B. Vibhute Organic Research Laboratory, P.G. Department of studies in Chemistry,Yeshwant Mahavidyalaya Nanded &#8211; 431602 (M.S.) India S.B. Zangade Organic Research Laboratory, P.G. Department of studies in Chemistry,Yeshwant Mahavidyalaya [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1221","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>An Improved Synthesis And Biological Evaluation Of Some New 4,5-dihydro-pyrazole1-Carbaldehyde Derivatives - Pakistan Journal of Chemistry<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2012\/03\/05\/pjc-0312\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"An Improved Synthesis And Biological Evaluation Of Some New 4,5-dihydro-pyrazole1-Carbaldehyde Derivatives - Pakistan Journal of Chemistry\" \/>\n<meta property=\"og:description\" content=\"Research Article | Open Access Volume 2 | Issue 1 | Paper 03 |&nbsp; https:\/\/doi.org\/10.15228\/2012.v02.i01.p03 An Improved Synthesis And Biological Evaluation Of Some New 4,5-dihydro-pyrazole1-Carbaldehyde Derivatives Y.B. 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