{"id":10217,"date":"2026-06-13T18:59:57","date_gmt":"2026-06-13T18:59:57","guid":{"rendered":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/?p=10217"},"modified":"2026-06-19T15:23:26","modified_gmt":"2026-06-19T15:23:26","slug":"pjc-1326","status":"publish","type":"post","link":"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/2026\/06\/13\/pjc-1326\/","title":{"rendered":"Phytochemical Profiling by GC\u2013MS and Evaluation of the Anticancer, Antioxidant, and Anti-Inflammatory Potential of Solanum surattense"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"10217\" class=\"elementor elementor-10217\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5f2b246 e-flex e-con-boxed e-con e-parent\" data-id=\"5f2b246\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-fd9d4fc e-con-full e-flex e-con e-child\" data-id=\"fd9d4fc\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-36fb7e9 elementor-widget elementor-widget-text-editor\" data-id=\"36fb7e9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<table border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\"><tbody><tr><td><div><strong>Research Article| Open Access<\/strong><\/div><div>Volume 16 | Issue 03 | Page 117-123|\u00a0<a style=\"font-size: 0.9em\" href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2026\/06\/PJC.v16.i03.p.13.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.15228\/2026.v16.i3.p13<\/a><\/div><\/td><\/tr><\/tbody><\/table><h4><strong><b>Phytochemical Profiling by GC\u2013MS and Evaluation of the Anticancer, Antioxidant, and Anti-Inflammatory Potential of <\/b><\/strong><strong><em><b><i>Solanum surattense<\/i><\/b><\/em><\/strong><\/h4><p><strong>Aurangzeb Ashraf<\/strong><br \/>Department of Chemistry, Faculty of Physical and Environmental Sciences, University of Balochistan, Quetta, Pakistan<\/p><p><a href=\"https:\/\/orcid.org\/0000-0001-8006-0705\" target=\"_blank\" rel=\"noopener\"><strong> Samar Ali<\/strong><\/a><br \/>Department of Chemistry, Faculty of Physical and Environmental Sciences, University of Balochistan, Quetta, Pakistan<\/p><p><strong> Nimra Fazal<\/strong><br \/>Department of Chemistry, Faculty of Physical and Environmental Sciences, University of Balochistan, Quetta, Pakistan<\/p><p><strong> Sara Zameer<\/strong><br \/>Department of Chemistry, Faculty of Physical and Environmental Sciences, University of Balochistan, Quetta, Pakistan<\/p><p><strong> Syed Shabbir Ahmed\u00a0<\/strong><br \/>Department of Chemistry, Faculty of Physical and Environmental Sciences, University of Balochistan, Quetta, Pakistan<\/p><p><strong>Nizam Ud-Din Baloch<\/strong><br \/>Department of Chemistry, Faculty of Physical and Environmental Sciences, University of Balochistan, Quetta, Pakistan<\/p><div><div><table border=\"0\" width=\"93%\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\"><tbody><tr><td align=\"center\" valign=\"top\"><strong>Received<\/strong><br \/>25 Apr, 2026<\/td><td align=\"center\" valign=\"top\"><strong>Accepted<\/strong><br \/>09 Jun, 2026<\/td><td align=\"center\" valign=\"top\"><strong>Published<\/strong><br \/>13 June, 2026<\/td><\/tr><\/tbody><\/table><div><p><strong>ABSTRACT:<\/strong><br \/><em><i>Solanum surattense<\/i><\/em>\u00a0(<em><i>S. surattense<\/i><\/em>) is a member of the genus <em><i>Solanum <\/i><\/em>and family <em><i>Solanaceae<\/i><\/em>, which comprises approximately 99 genera and 2000 species. The present work was conducted to evaluate GC-MS and FTIR analyses, followed by biological activity assessment of the medicinal plant <em><i>S. surattense<\/i><\/em>\u00a0from Baluchistan. Pakistan. The GC-MS was used to identify volatile constituents present in the n-hexane fraction of the plant. The functional groups of these were identified in the methanolic extract through FTIR analysis. Moreover, anti-inflammatory, antioxidant, and anti-cancer properties were evaluated in the plant&#8217;s methanolic extract using colorimetric, free-radical scavenging, and chemiluminescence methods, respectively. Twenty-five volatile compounds were identified by GC-MS analysis. The FTIR spectrum of the methanolic extract also indicated the presence of various functional groups, including alcohols, alkanes, aldehydes, aromatic compounds, and esters.The anticancer activity results demonstrated that the methanolic extract exhibited a relatively high IC\u2085\u2080 value of 90.5 \u00b1 1.5 \u00b5g\/mL. In contrast, the standard drug Doxorubicin exhibited a much lower IC\u2085\u2080 value of 0.79 \u00b1 0.13 \u00b5g\/mL. The methanolic extract of the plant exhibited minimal cytotoxic potential compared with HeLa cervical cell line. The antioxidant activity results revealed that the methanolic extract of the plant exhibited inhibition with an IC\u2085\u2080 of 800 \u00b1 5 \u00b5g\/mL, indicating weak antioxidant activity compared to the standard antioxidant, gallic acid, which had an IC\u2085\u2080 of 21.7 \u00b1 0.22 \u00b5g\/mL. These findings suggest that <em><i>Solanum surattense<\/i><\/em>\u00a0possesses antioxidant potential, although its efficacy is considerably lower than that of gallic acid. The methanolic extract of <em><i>S. surattense<\/i><\/em>\u00a0showed moderate anti-inflammatory activity (66.6 \u00b1 13.2 \u00b5g\/mL) compared with ibuprofen (11.2 \u00b1 1.9 \u00b5g\/mL). Despite its lower potency, the plant demonstrated promising anti-inflammatory properties and may serve as a potential natural source of anti-inflammatory compounds.<\/p><p><strong>Keywords: GC-MS, FTIR, Antioxidant, Anti-inflammatory, Anticancer<\/strong><\/p><p><strong>How to Cite this paper?<\/strong><\/p><\/div><div><div><p><strong>APA- Style<\/strong><br \/>A. Ashraf, S. Ali, N. Fazal, S. Zameer, S. S. Ahmed, N. Baloch, (2026). Phytochemical Profiling by GC\u2013MS and Evaluation of the Anticancer, Antioxidant, and Anti-Inflammatory Potential of <em><i>Solanum surattense<\/i><\/em> <a href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2026\/06\/PJC.v16.i03.p.13.pdf\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>, 16(3), 117-123.<\/a> https:\/\/doi.org\/10.15228\/2026.v16.i3.p.117-123.<\/p><p><strong>ACS Style<\/strong><\/p><p>Ashraf A., Ali S., Fazal N., Zameer S., Ahmed S. S., Baloch N., <em>Phytochemical Profiling by GC\u2013MS and Evaluation of the Anticancer, Antioxidant, and Anti-Inflammatory Potential of Solanum surattense<\/em> <a href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2026\/06\/PJC.v16.i03.p.13.pdf\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>, 16(3), 117-123.<\/a> https:\/\/doi.org\/10.15228\/2026.v16.i3.p.117-123.<\/p><p><strong>AMA Style<\/strong><\/p><p>Ashraf A; Ali S; Fazal N; Zameer S; Ahmed S. S; Baloch N; <em>Phytochemical Profiling by GC\u2013MS and Evaluation of the Anticancer, Antioxidant, and Anti-Inflammatory Potential of Solanum surattense (2026)<\/em> <a href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2026\/06\/PJC.v16.i03.p.13.pdf\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>, 16(3), 117-123.<\/a> https:\/\/doi.org\/10.15228\/2026.v16.i3.p.117-123.<\/p><p><strong>Chicago\/Turabian Style<\/strong><\/p><p>Ashraf A, Ali S, Fazal N, Zameer S, Ahmed SS, Baloch N, <em>Phytochemical Profiling by GC\u2013MS and Evaluation of the Anticancer, Antioxidant, and Anti-Inflammatory Potential of Solanum surattense<\/em> <a href=\"https:\/\/chempublishers.com\/Pakistan-journal-of-chemistry\/wp-content\/uploads\/sites\/2\/2026\/06\/PJC.v16.i03.p.13.pdf\" target=\"_blank\" rel=\"noopener\"><em>Pakistan Journal of Chemistry<\/em>, 16(3), 117-123.<\/a> https:\/\/doi.org\/10.15228\/2026.v16.i3.p.117-123.<\/p><p><a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\"><img decoding=\"async\" src=\"https:\/\/i.creativecommons.org\/l\/by\/4.0\/88x31.png\" alt=\"Creative Commons License\" \/><\/a><\/p><\/div><\/div><div><p>This work is licensed under a\u00a0<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">Creative Commons Attribution 4.0 International License<\/a>.<\/p><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6419e66 e-con-full e-flex e-con e-child\" data-id=\"6419e66\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Research Article| Open AccessVolume 16 | Issue 03 | Page 117-123|\u00a0https:\/\/doi.org\/10.15228\/2026.v16.i3.p13 Phytochemical Profiling by GC\u2013MS and Evaluation of the Anticancer, Antioxidant, and Anti-Inflammatory Potential of Solanum surattense Aurangzeb AshrafDepartment of Chemistry, Faculty of Physical and Environmental Sciences, University of Balochistan, Quetta, Pakistan Samar AliDepartment of Chemistry, Faculty of Physical and Environmental Sciences, University of Balochistan, [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[66,68],"tags":[],"class_list":["post-10217","post","type-post","status-publish","format-standard","hentry","category-66","category-issue-3"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Phytochemical Profiling by GC\u2013MS and Evaluation of the Anticancer, Antioxidant, and Anti-Inflammatory Potential of Solanum surattense 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